ENSMUSG00000068205


Mus musculus

Features
Gene ID: ENSMUSG00000068205
  
Biological name :Macrod2
  
Synonyms : Macrod2 / O-acetyl-ADP-ribose deacetylase MACROD2 / Q3UYG8
  
Possible biological names infered from orthology : A1Z1Q3 / MACRO domain containing 2
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F3
Gene start: 140395309
Gene end: 142392966
  
Corresponding Affymetrix probe sets: 10476582 (MoGene1.0st)   10476588 (MoGene1.0st)   10476590 (MoGene1.0st)   10476592 (MoGene1.0st)   10476594 (MoGene1.0st)   10476596 (MoGene1.0st)   1431159_at (Mouse Genome 430 2.0 Array)   1432431_s_at (Mouse Genome 430 2.0 Array)   1443058_at (Mouse Genome 430 2.0 Array)   1453025_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105694
Ensembl peptide - ENSMUSP00000105691
Ensembl peptide - ENSMUSP00000121013
Ensembl peptide - ENSMUSP00000041780
Ensembl peptide - ENSMUSP00000077174
Ensembl peptide - ENSMUSP00000105688
Ensembl peptide - ENSMUSP00000105689
Ensembl peptide - ENSMUSP00000105690
NCBI entrez gene - 72899     See in Manteia.
MGI - MGI:1920149
RefSeq - XM_017319285
RefSeq - XM_006500248
RefSeq - XM_006500249
RefSeq - XM_006500250
RefSeq - XM_006500251
RefSeq - XM_006500252
RefSeq - XM_006500253
RefSeq - XM_011239794
RefSeq - XM_017319283
RefSeq - NM_001013802
RefSeq - NM_028387
RefSeq - XM_006500246
RefSeq - XM_006500247
RefSeq Peptide - NP_001013824
RefSeq Peptide - NP_082663
swissprot - Q9D117
swissprot - A2AS33
swissprot - Q05C81
swissprot - F6TQH7
swissprot - Q3UYG8
swissprot - B1AW12
Ensembl - ENSMUSG00000068205
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 macrod2ENSDARG00000032601Danio rerio
 A1Z1Q3ENSG00000172264Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q922B1 / Macrod1 / O-acetyl-ADP-ribose deacetylase MACROD1 / Q9BQ69* / MACRO domain containing 1*ENSMUSG0000003627827
Gdap2 / Q9DBL2 / Ganglioside-induced differentiation-associated protein 2 / Q9NXN4*ENSMUSG0000002786512


Protein motifs (from Interpro)
Interpro ID Name
 IPR002589  Macro domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007420 brain development IEP
 biological_processGO:0042278 purine nucleoside metabolic process ISO
 biological_processGO:0051725 protein de-ADP-ribosylation ISO
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005813 centrosome ISO
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds ISO
 molecular_functionGO:0019213 deacetylase activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0011275 abnormal behavioral response to light "unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
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Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Ghrhrtm1.1(KOMP)Vlcg/Ghrhrtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ghrhrtm1.1(KOMP)Vlcg/J

Allelic Composition: Macrod2tm1.1(KOMP)Vlcg/Macrod2tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Macrod2tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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