MP:0000250 | abnormal vasoconstriction | "anomalous narrowing of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Hnos/Cry2tm1Hnos Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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MP:0000609 | abnormal liver physiology | "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Cry2tm1.1Yf/Cry2tm1.1Yf Genetic Background: B6J.Cg-Cry2tm1.1Yf
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Mettm1Cpo/Mettm2Cpo Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Hnos/Cry2tm1Hnos Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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MP:0001325 | abnormal retina morphology | "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh Genetic Background: either: B6.129-Bmp8btm1Blh or (involves: 129 * Black Swiss * C57BL/6)
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MP:0001326 | retinal degeneration | "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator] |
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Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh Genetic Background: either: B6.129-Bmp8btm1Blh or (involves: 129 * Black Swiss * C57BL/6)
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MP:0001402 | hypoactivity | "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289] |
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Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh Genetic Background: either: B6.129-Bmp8btm1Blh or (involves: 129 * Black Swiss * C57BL/6)
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MP:0001541 | abnormal osteoclast function | "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795] |
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0001828 | abnormal T cell activation | "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002891 | increased insulin sensitivity | "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission] |
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Allelic Composition: Mettm1Cpo/Mettm2Cpo Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0002971 | abnormal brown fat morphology | "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Mettm1Cpo/Mettm2Cpo Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0003724 | susceptibility to induced arthritis | "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator] |
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0003731 | abnormal outer nuclear layer morphology | "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Asn/Cry2tm1Asn,Pde6brd1/Pde6brd1 Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
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MP:0004184 | abnormal baroreceptor physiology | "anomaly in the function of the sensory nerve endings found in the wall of the atria of the heart, vena cava, aortic arch and carotid sinus that are sensitive to changes in blood pressure" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Hnos/Cry2tm1Hnos Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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MP:0004988 | increased osteoblast cell number | "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: F5tm2Dgi/F5tm2Dgi Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0004989 | decreased osteoblast cell number | "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Per2tm1Brd/Per2tm1Brd Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
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MP:0005289 | increased oxygen consumption | "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Mettm1Cpo/Mettm2Cpo Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0005293 | impaired glucose tolerance | "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Mettm1Cpo/Mettm2Cpo Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0005605 | increased bone mass | "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: F5tm2Dgi/F5tm2Dgi Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0006243 | abnormal pupil dilation reaction to light | "the pupil fails to constrict fully when exposed to bright light" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp8btm1Blh/Bmp8btm1Blh Genetic Background: either: B6.129-Bmp8btm1Blh or (involves: 129 * Black Swiss * C57BL/6)
Allelic Composition: Cry2tm1Asn/Cry2tm1Asn,Pde6brd1/Pde6brd1 Genetic Background: involves: 129P2/OlaHsd
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MP:0008446 | decreased retinal cone cell number | "reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Asn/Cry2tm1Asn,Pde6brd1/Pde6brd1 Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
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MP:0008454 | absent retinal rod cells | "absence of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650] |
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Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Asn/Cry2tm1Asn,Pde6brd1/Pde6brd1 Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
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MP:0008553 | increased circulating tumor necrosis factor level | "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0008560 | increased tumor necrosis factor secretion | "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0008585 | absent photoreceptor outer segment | "absence of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Asn/Cry2tm1Asn,Pde6brd1/Pde6brd1 Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
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MP:0008596 | increased circulating interleukin-6 level | "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506] |
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0008641 | increased circulating interleukin-1 beta level | "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600] |
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0008844 | decreased subcutaneous adipose tissue amount | "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mettm1Cpo/Mettm2Cpo Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0008853 | decreased abdominal adipose tissue amount | "reduction in amount of adipose tissue associated with internal organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mettm1Cpo/Mettm2Cpo Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0010025 | decreased total body fat amount | "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mettm1Cpo/Mettm2Cpo Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0010875 | increased bone volume | "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0011020 | abnormal circadian temperature homeostasis | "any anomaly in the process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours" [GO:0060086] |
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Allelic Composition: Mettm1Cpo/Mettm2Cpo Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0011021 | abnormal circadian regulation of heart rate | "anomaly in the process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours" [GO:0003053] |
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Allelic Composition: Mettm1Cpo/Mettm2Cpo Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Hnos/Cry2tm1Hnos Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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MP:0011022 | abnormal circadian regulation of systemic arterial blood pressure | "any anomaly in the process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours" [GO:0003052] |
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Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Hnos/Cry2tm1Hnos Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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MP:0020040 | decreased bone ossification | "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597] |
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Per2tm1Brd/Per2tm1Brd Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
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MP:0020467 | abnormal circadian behavior | "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512] |
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Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Hnos/Cry2tm1Hnos Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0020468 | abnormal circadian behavior period | "any change in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb] |
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Allelic Composition: Cry2tm1Jhjh/Cry2tm1Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0020469 | prolonged circadian behavior period | "increase in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb] |
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Allelic Composition: Mettm1Cpo/Mettm2Cpo Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Cry2tm1Jhjh/Cry2tm1Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cry2tm1Asn/Cry2tm1Asn,Fbxl3tm1.1Ljp/Fbxl3tm1.1Ljp Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Cry2tm1.1Yf/Cry2tm1.1Yf Genetic Background: B6J.Cg-Cry2tm1.1Yf
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MP:0020471 | abnormal circadian behavior persistence | "anomaly in the ability for an animal to retain a circadian behavior when time cues are removed" [MGI:smb] |
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Allelic Composition: Mettm1Cpo/Mettm2Cpo Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
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MP:0020472 | arrhythmic circadian behavior persistence | "loss of a behavioral rhythmic pattern upon removal of time cues" [MGI:smb] |
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Allelic Composition: Mettm1Cpo/Mettm2Cpo Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0020473 | abnormal circadian behavior phase | "anomaly in the phase relationship between a temporal synchronizing event (such as light cycle) and a behavioral phase reference point of an animal (such as activity onset)" [MGI:smb] |
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Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Asn/Cry2tm1Asn,Pde6brd1/Pde6brd1 Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
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MP:0020477 | abnormal locomotor circadian rhythm | "any anomaly in the rhythm of the locomotor activity of an organism during its 24 hour activity cycle" [GO:0045475] |
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Allelic Composition: Cry1tm1Asn/Cry1tm1Asn,Cry2tm1Asn/Cry2tm1Asn,Pde6brd1/Pde6brd1 Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
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