ENSMUSG00000070427


Mus musculus

Features
Gene ID: ENSMUSG00000070427
  
Biological name :Il18bp
  
Synonyms : Il18bp / Interleukin-18-binding protein / Q9Z0M9
  
Possible biological names infered from orthology : O95998
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E2
Gene start: 102014885
Gene end: 102018690
  
Corresponding Affymetrix probe sets: 10566050 (MoGene1.0st)   1450424_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147912
Ensembl peptide - ENSMUSP00000148201
Ensembl peptide - ENSMUSP00000148080
Ensembl peptide - ENSMUSP00000091685
NCBI entrez gene - 16068     See in Manteia.
MGI - MGI:1333800
RefSeq - NM_010531
RefSeq - XM_017321987
RefSeq Peptide - NP_034661
swissprot - A0A1B0GT50
swissprot - Q9Z0M9
swissprot - A0A1B0GSF2
Ensembl - ENSMUSG00000070427
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL18BPENSG00000137496Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0042088 T-helper 1 type immune response IBA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:1900116 extracellular negative regulation of signal transduction IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0042007 interleukin-18 binding ISO
 molecular_functionGO:0048019 receptor antagonist activity IBA


Pathways (from Reactome)
Pathway description
Interleukin-18 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fzd4tm1.1(KOMP)Vlcg/Fzd4tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fzd4tm1.1(KOMP)Vlcg/Ucd

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Sox1tm1(cre)Take/Sox1+
Genetic Background: involves: 129 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008053 abnormal NK cell differentiation "atypical production of or inability to produce the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Sox1tm1(cre)Take/Sox1+
Genetic Background: involves: 129 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Sox1tm1(cre)Take/Sox1+
Genetic Background: involves: 129 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Sox1tm1(cre)Take/Sox1+
Genetic Background: involves: 129 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0012768 decreased KLRG1-positive NK cell number "decrease in the number of KLRG1 positive NK cells that represent a maturation subset of NK cells and is linked to NK cell proliferation" [MGI:Annie_Speak, PMID:19479342]
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Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Sox1tm1(cre)Take/Sox1+
Genetic Background: involves: 129 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0013667 increased immature NK cell number "increase in the number of NK cells lacking expression of the maturation marker CD11b" [MGI:Saran]
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Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Sox1tm1(cre)Take/Sox1+
Genetic Background: involves: 129 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0013672 decreased mature NK cell number "reduction in the number of NK cells expressing the maturation marker CD11b" [MGI:Saran]
Show

Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Sox1tm1(cre)Take/Sox1+
Genetic Background: involves: 129 * C57BL/6NCrlj * CBA/JNCrlj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039217 Il18 / P70380 / Interleukin-18 / Q14116*  / complex / reaction






 

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