ENSMUSG00000070495


Mus musculus

Features
Gene ID: ENSMUSG00000070495
  
Biological name :Ctcfl
  
Synonyms : A2APF3 / Ctcfl / Transcriptional repressor CTCFL
  
Possible biological names infered from orthology : CCCTC-binding factor like / Q8NI51
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H3
Gene start: 173093609
Gene end: 173119525
  
Corresponding Affymetrix probe sets: 10490138 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000135932
Ensembl peptide - ENSMUSP00000091845
NCBI entrez gene - 664799     See in Manteia.
MGI - MGI:3652571
RefSeq - NM_001081387
RefSeq - XM_017319167
RefSeq - XM_017319168
RefSeq Peptide - NP_001074856
swissprot - A2APF3
Ensembl - ENSMUSG00000070495
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CTCFLENSG00000124092Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctcf / Q61164 / Mus musculus CCCTC-binding factor (Ctcf), transcript variant 2, mRNA. / P49711* / CCCTC-binding factor*ENSMUSG0000000569845
Zfp64 / Q99KE8 / zinc finger protein 64 / Q9NTW7* / Q9NPA5* / ZFP64 zinc finger protein*ENSMUSG0000002755121
A2A5K6 / Zfp335 / zinc finger protein 335 / Q9H4Z2* / ZNF335*ENSMUSG0000003983420


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006349 regulation of gene expression by genetic imprinting IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0016571 histone methylation IDA
 biological_processGO:0043046 DNA methylation involved in gamete generation IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0051569 regulation of histone H3-K4 methylation ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042393 histone binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

Allelic Composition: Ctcfltm1.1Vloc/Ctcfltm1.1Vloc
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

Allelic Composition: Ctcfltm1.1Vloc/Ctcfltm1.1Vloc
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0001940 testicular hypoplasia "decreased cell number in the testicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spta1sph/Spta1sph
Genetic Background: (WB.C3-Spta1sph x B6.C3-Spta1sph)F1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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