ENSMUSG00000071573


Mus musculus

Features
Gene ID: ENSMUSG00000071573
  
Biological name :Rnls
  
Synonyms : renalase, FAD dependent amine oxidase / Rnls
  
Possible biological names infered from orthology : Q5VYX0
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C1
Gene start: 33137747
Gene end: 33392295
  
Corresponding Affymetrix probe sets: 10467102 (MoGene1.0st)   1453180_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000093825
Ensembl peptide - ENSMUSP00000127592
NCBI entrez gene - 67795     See in Manteia.
MGI - MGI:1915045
RefSeq - NM_001167818
RefSeq - NM_001146342
RefSeq - XM_017318288
RefSeq Peptide - NP_001139814
RefSeq Peptide - NP_001161290
swissprot - E9Q243
swissprot - A0A0R4J156
Ensembl - ENSMUSG00000071573
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnlsENSDARG00000012453Danio rerio
 RNLSENSGALG00000029829Gallus gallus
 RNLSENSG00000184719Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002937  Amine oxidase
 IPR036188  FAD/NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010459 negative regulation of heart rate IEA
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016651 oxidoreductase activity, acting on NAD(P)H IEA
 molecular_functionGO:0051379 epinephrine binding IEA
 molecular_functionGO:0070404 NADH binding IEA
 molecular_functionGO:0097621 monoamine oxidase activity IEA


Pathways (from Reactome)
Pathway description
Nicotinamide salvaging


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Shank3tm1.1Geno/Shank3tm1.1Geno
Genetic Background: involves: C57BL/6

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Shank3tm1.1Geno/Shank3tm1.1Geno
Genetic Background: involves: C57BL/6

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Shank3tm1.1Geno/Shank3tm1.1Geno
Genetic Background: involves: C57BL/6

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Shank3tm1.1Geno/Shank3tm1.1Geno
Genetic Background: involves: C57BL/6

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Shank3tm1.1Geno/Shank3tm1.1Geno
Genetic Background: involves: C57BL/6

 MP:0003037 increased infarction size "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Shank3tm1.1Geno/Shank3tm1.1Geno
Genetic Background: involves: C57BL/6

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Shank3tm1.1Geno/Shank3tm1.1Geno
Genetic Background: involves: C57BL/6

 MP:0005662 increased circulating adrenaline level "greater than the normal concentration in the blood of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Shank3tm1.1Geno/Shank3tm1.1Geno
Genetic Background: involves: C57BL/6

 MP:0005665 increased circulating noradrenaline level "greater than the normal blood concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Shank3tm1.1Geno/Shank3tm1.1Geno
Genetic Background: involves: C57BL/6

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Shank3tm1.1Geno/Shank3tm1.1Geno
Genetic Background: involves: C57BL/6

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Shank3tm1.1Geno/Shank3tm1.1Geno
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr