ENSMUSG00000071648


Mus musculus

Features
Gene ID: ENSMUSG00000071648
  
Biological name :Rom1
  
Synonyms : P32958 / Rod outer segment membrane protein 1 / Rom1
  
Possible biological names infered from orthology : Q03395 / retinal outer segment membrane protein 1
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 8927382
Gene end: 8929356
  
Corresponding Affymetrix probe sets: 10465833 (MoGene1.0st)   1448996_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000093961
NCBI entrez gene - 19881     See in Manteia.
MGI - MGI:97998
RefSeq - NM_009073
RefSeq Peptide - NP_033099
swissprot - P32958
Ensembl - ENSMUSG00000071648
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rom1aENSDARG00000019752Danio rerio
 rom1bENSDARG00000026926Danio rerio
 ROM1ENSG00000149489Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prph2 / P15499 / Peripherin-2 / P23942*ENSMUSG0000002397835


Protein motifs (from Interpro)
Interpro ID Name
 IPR000830  Peripherin/rom-1
 IPR008952  Tetraspanin, EC2 domain superfamily
 IPR018498  Peripherin/rom-1, conserved site
 IPR018499  Tetraspanin/Peripherin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0060042 retina morphogenesis in camera-type eye IMP
 biological_processGO:0060219 camera-type eye photoreceptor cell differentiation IMP
 biological_processGO:0061298 retina vasculature development in camera-type eye IMP
 cellular_componentGO:0001750 photoreceptor outer segment IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042622 photoreceptor outer segment membrane IDA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Rom1Rgsc1156/Rom1+
Genetic Background: (DBA/2JJcl x C57BL/6JJcl)F1

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Fgfr3tm1.1Iwa/Fgfr3tm1.1Iwa
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss * CD-1 * FVB/N

 MP:0002864 abnormal ocular fundus morphology "malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rom1Rgsc1156/Rom1+
Genetic Background: (DBA/2JJcl x C57BL/6JJcl)F1

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Fgfr3tm1.1Iwa/Fgfr3tm1.1Iwa
Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss * CD-1 * FVB/N

Allelic Composition: Rom1Rgsc1156/Rom1Rgsc1156
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0008451 retinal rod cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
Show

Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa3tm1Mrc/Hoxa3tm1Mrc,Hoxb3tm1Mrc/Hoxb3tm1Mrc
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Rom1Rgsc1156/Rom1+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Rom1Rgsc1156/Rom1Rgsc1156
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0008586 disorganized photoreceptor outer segment "derangement of the pattern of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rom1Rgsc1156/Rom1+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0008587 short photoreceptor outer segment "decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rom1Rgsc1156/Rom1+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Rom1Rgsc1156/Rom1Rgsc1156
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0010097 abnormal retinal blood vessel morphology "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rom1Rgsc1156/Rom1+
Genetic Background: (DBA/2JJcl x C57BL/6JJcl)F1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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