ENSMUSG00000072663


Mus musculus

Features
Gene ID: ENSMUSG00000072663
  
Biological name :Spef2
  
Synonyms : Q8C9J3 / Spef2 / Sperm flagellar protein 2
  
Possible biological names infered from orthology : Q9C093 / sperm flagellar 2
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: A1
Gene start: 9578193
Gene end: 9748868
  
Corresponding Affymetrix probe sets: 10427640 (MoGene1.0st)   10427653 (MoGene1.0st)   10427655 (MoGene1.0st)   10427657 (MoGene1.0st)   10427659 (MoGene1.0st)   10427661 (MoGene1.0st)   10427663 (MoGene1.0st)   10427665 (MoGene1.0st)   10427667 (MoGene1.0st)   10427669 (MoGene1.0st)   10427671 (MoGene1.0st)   10427675 (MoGene1.0st)   10427677 (MoGene1.0st)   10427679 (MoGene1.0st)   10427681 (MoGene1.0st)   10427683 (MoGene1.0st)   10427685 (MoGene1.0st)   10427687 (MoGene1.0st)   10427689 (MoGene1.0st)   10427691 (MoGene1.0st)   10427693 (MoGene1.0st)   1446747_at (Mouse Genome 430 2.0 Array)   1458911_at (Mouse Genome 430 2.0 Array)   1459122_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124222
Ensembl peptide - ENSMUSP00000146967
Ensembl peptide - ENSMUSP00000124891
Ensembl peptide - ENSMUSP00000124723
Ensembl peptide - ENSMUSP00000124393
Ensembl peptide - ENSMUSP00000035762
NCBI entrez gene - 320277     See in Manteia.
MGI - MGI:2443727
RefSeq - XM_017316668
RefSeq - NM_001305042
RefSeq - NM_001305044
RefSeq - NM_177123
RefSeq - XM_017316667
RefSeq Peptide - NP_001291973
RefSeq Peptide - NP_001291971
RefSeq Peptide - NP_796097
swissprot - A0A140LIV1
swissprot - E0CY95
swissprot - E0CX63
swissprot - E0CYG3
swissprot - Q8C9J3
Ensembl - ENSMUSG00000072663
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spef2ENSDARG00000098330Danio rerio
 SPEF2ENSGALG00000023552Gallus gallus
 SPEF2ENSG00000152582Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006580  Zinc finger, TTF-type
 IPR010441  CH-like domain in sperm protein
 IPR011992  EF-hand domain pair
 IPR012337  Ribonuclease H-like superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003351 epithelial cilium movement IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007288 sperm axoneme assembly IMP
 biological_processGO:0048705 skeletal system morphogenesis IMP
 biological_processGO:0048854 brain morphogenesis IMP
 biological_processGO:0060541 respiratory system development IMP
 cellular_componentGO:0002177 manchette IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0097225 sperm midpiece IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
Show

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0001872 sinus inflammation "increase in susceptibility of the hollow cavities in bone (usually but not exclusively those in the skull) to allergens and/or pathogens" [MGI:tc, J:60896]
Show

Allelic Composition: Spef2bgh/Spef2bgh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/10J

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

Allelic Composition: Spef2bgh/Spef2bgh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/10J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0002176 high brain weight "greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Spef2bgh/Spef2bgh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/10J

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Spef2bgh/Spef2bgh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/10J

 MP:0009239 short sperm flagellum "decreased length of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spef2bgh/Spef2bgh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/10J

 MP:0009838 abnormal sperm axoneme morphology "any structural abnormality of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion" [PMID:14581499]
Show

Allelic Composition: Spef2bgh/Spef2bgh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/10J

 MP:0011055 abnormal respiratory motile cilium physiology "any functional anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract; may include alterations in ciliary beating pattern or frequency" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

Allelic Composition: Spef2bgh/Spef2bgh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/10J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

 MP:0030316 enlarged neurocranium "increased size of the bones of the skull enclosing the brain" [MGI:anna]
Show

Allelic Composition: Nfatc1tm1Rao/Nfatc1tm1Rao,Nfatc2tm1Rao/Nfatc2tm1Rao,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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