ENSMUSG00000073436


Mus musculus

Features
Gene ID: ENSMUSG00000073436
  
Biological name :Eme2
  
Synonyms : Eme2 / Probable crossover junction endonuclease EME2 / Q56A04
  
Possible biological names infered from orthology : A4GXA9 / essential meiotic structure-specific endonuclease subunit 2
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 24888486
Gene end: 24895087
  
Corresponding Affymetrix probe sets: 10448755 (MoGene1.0st)   1429034_at (Mouse Genome 430 2.0 Array)   1442853_at (Mouse Genome 430 2.0 Array)   1460628_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113167
Ensembl peptide - ENSMUSP00000118245
Ensembl peptide - ENSMUSP00000113936
NCBI entrez gene - 193838     See in Manteia.
MGI - MGI:1919889
RefSeq - NM_001163102
RefSeq Peptide - NP_001156574
swissprot - D6RIK4
swissprot - D3Z6X0
swissprot - Q56A04
Ensembl - ENSMUSG00000073436
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EME2ENSGALG00000002276Gallus gallus
 EME2ENSG00000197774Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eme1 / Q8BJW7 / Crossover junction endonuclease EME1 / Q96AY2* / essential meiotic structure-specific endonuclease 1*ENSMUSG0000003905531


Protein motifs (from Interpro)
Interpro ID Name
 IPR006166  ERCC4 domain
 IPR033310  Mms4/EME1/EME2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000712 resolution of meiotic recombination intermediates IBA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair IBA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0031297 replication fork processing IBA
 biological_processGO:0031573 intra-S DNA damage checkpoint IBA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0000790 nuclear chromatin IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0048476 Holliday junction resolvase complex IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0008821 crossover junction endodeoxyribonuclease activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Resolution of D-loop Structures through Holliday Junction Intermediates
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024906 Mus81 / Q91ZJ0 / Crossover junction endonuclease MUS81 / Q96NY9* / MUS81 structure-specific endonuclease subunit*  / complex






 

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