ENSMUSG00000073599


Mus musculus

Features
Gene ID: ENSMUSG00000073599
  
Biological name :Ecscr
  
Synonyms : Ecscr / Endothelial cell-specific chemotaxis regulator / Q3TZW0
  
Possible biological names infered from orthology : AC142391.1 / endothelial cell surface expressed chemotaxis and apoptosis regulator / Q19T08
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B2
Gene start: 35713086
Gene end: 35722356
  
Corresponding Affymetrix probe sets: 10458303 (MoGene1.0st)   1437451_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000095223
Ensembl peptide - ENSMUSP00000116109
Ensembl peptide - ENSMUSP00000118479
Ensembl peptide - ENSMUSP00000118628
NCBI entrez gene - 68545     See in Manteia.
MGI - MGI:1915795
RefSeq - XM_006526210
RefSeq - NM_001033141
RefSeq Peptide - NP_001028313
swissprot - F6W6D3
swissprot - F6RF12
swissprot - Q3TZW0
swissprot - G3UVV5
Ensembl - ENSMUSG00000073599
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ecscrENSDARG00000087457Danio rerio
 ENSGALG00000024379Gallus gallus
 AC142391.1ENSG00000279686Homo sapiens
 ECSCRENSG00000249751Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026247  Endothelial cell-specific chemotaxis regulator


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016525 negative regulation of angiogenesis ISO
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:1901800 positive regulation of proteasomal protein catabolic process ISO
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Mgat1tm2Jxm/Mgat1tm2Jxm,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Mgat1tm2Jxm/Mgat1tm2Jxm,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cygbtm1Nka/Cygb+
Genetic Background: B6.Cg-Cygbtm1Nka

 MP:0003443 increased circulating glycerol level "higher than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Mgat1tm2Jxm/Mgat1tm2Jxm,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003544 abnormal vascular endothelial cell migration "anomaly in the movement of endothelial cell or their precursors to the appropriate location in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387]
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Allelic Composition: Cygbtm1Nka/Cygb+
Genetic Background: B6.Cg-Cygbtm1Nka

 MP:0003711 abnormal pathological neovascularization "the proliferation of blood vessels in abnormal tissues or in abnormal positions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cygbtm1Nka/Cygb+
Genetic Background: B6.Cg-Cygbtm1Nka

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Mgat1tm2Jxm/Mgat1tm2Jxm,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008034 enhanced lipolysis "increase in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Mgat1tm2Jxm/Mgat1tm2Jxm,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0020322 decreased vascular endothelial cell apoptosis "decrease in the timing or the number of vascular endothelial cells undergoing programmed cell death" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Cygbtm1Nka/Cygb+
Genetic Background: B6.Cg-Cygbtm1Nka

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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