MP:0000220 | increased monocyte count | "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0000490 | abnormal crypts of Lieberkuhn morphology | "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0000496 | abnormal small intestine morphology | "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL
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MP:0000511 | abnormal intestinal mucosa morphology | "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL
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MP:0000512 | intestinal ulcer | "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0002038 | carcinoma | "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0002404 | intestinal adenoma | "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0002580 | duodenal lesions | "any pathological change in the structure of the wall of the duodenum" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183] |
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Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL
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MP:0002581 | abnormal ileum morphology | "malformation of the portion of the small intestine that extends from the jejunum to the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183] |
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Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL
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MP:0003271 | abnormal duodenum morphology | "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL
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MP:0003293 | rectal hemorrhage | "bleeding in the rectum" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0003306 | small intestinal inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL
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MP:0003721 | increased tumor growth/size | "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0004499 | increased incidence of chemically-induced tumors | "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0005015 | increased T cell number | "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0005036 | diarrhea | "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0005425 | increased macrophage count | "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0008108 | abnormal small intestinal villus morphology | "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL
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MP:0008537 | increased susceptibility to induced colitis | "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0008560 | increased tumor necrosis factor secretion | "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0008566 | increased interferon-gamma secretion | "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0008687 | increased interleukin-2 secretion | "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0008883 | abnormal enterocyte proliferation | "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0009308 | adenocarcinoma | "malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0009311 | duodenum adenocarcinoma | "malignant neoplasm of epithelial cells in the duodenum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL
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MP:0009766 | increased sensitivity to xenobiotic induced morbidity/mortality | "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0010180 | increased susceptibility to weight loss | "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0010279 | increased gastrointestinal tumor incidence | "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0012408 | increased duodenum glandular epithelium tumor incidence | "greater than the expected number of tumors originating in the duodenal glandular epithelium in a given population in a given time period" [MGI:csmith] |
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Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL
Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil-cre/ERT2)23Syr/0 Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2
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MP:0013482 | abnormal duodenum crypts of Lieberkuhn morphology | "any structural anomaly of the intestinal crypts located in the mucosa of the duodenum, the first division of the small intestine that extends from the pyloris to the junction with the jejunum" [MGI:Anna] |
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Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL
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MP:0013956 | decreased colon length | "reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088] |
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/? Genetic Background: involves: 129S4/SvJae * C57BL/6
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