ENSMUSG00000074004


Mus musculus

Features
Gene ID: ENSMUSG00000074004
  
Biological name :B3gnt6
  
Synonyms : Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase / B3gnt6 / Q3USF0
  
Possible biological names infered from orthology : Q6ZMB0 / UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E1
Gene start: 98192417
Gene end: 98199481
  
Corresponding Affymetrix probe sets: 10565709 (MoGene1.0st)   1456680_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000095879
NCBI entrez gene - 272411     See in Manteia.
MGI - MGI:3039603
RefSeq - NM_001081167
RefSeq Peptide - NP_001074636
swissprot - Q3USF0
Ensembl - ENSMUSG00000074004
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 B3GNT6ENSG00000198488Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
B3gnt3 / Q5JCS9 / N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3 / Q9Y2A9* / UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3*ENSMUSG0000003180342
B3gnt9 / Q8VI16 / UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 / Q6UX72*ENSMUSG0000006992036
B3gnt7 / Q8K0J2 / UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 / Q8NFL0*ENSMUSG0000007944536
B3gnt4 / Q1RLK6 / N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4 / Q9C0J1* / UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4*ENSMUSG0000002943135
B3gnt2 / Q9Z222 / N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 / Q9NY97* / UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2*ENSMUSG0000005165034
B3gnt8 / Q8R3I9 / UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 / Q7Z7M8*ENSMUSG0000005947930
O54905 / B3galt2 / Beta-1,3-galactosyltransferase 2 / O43825*ENSMUSG0000003384924
Q9Z0F0 / B3galt4 / Beta-1,3-galactosyltransferase 4 / O96024*ENSMUSG0000006737024
B3gnt5 / Q8BGY6 / Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase / Q9BYG0* / UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5*ENSMUSG0000002268623
O54904 / B3galt1 / Beta-1,3-galactosyltransferase 1 / Q9Y5Z6*ENSMUSG0000003478021
Q920V1 / B3galnt1 / UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 / O75752* / beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)*ENSMUSG0000004330021
Q9JI67 / B3galt5 / Mus musculus UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 (B3galt5), transcript variant 4, mRNA. / Q9Y2C3* / beta-1,3-galactosyltransferase 5*ENSMUSG0000007489221
Gm34653 / UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 10 (putative) / A8MXE2* / B3GNT10*ENSMUSG0000010716719


Protein motifs (from Interpro)
Interpro ID Name
 IPR002659  Glycosyl transferase, family 31


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008378 galactosyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0047224 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity IEA


Pathways (from Reactome)
Pathway description
O-linked glycosylation of mucins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002580 duodenal lesions "any pathological change in the structure of the wall of the duodenum" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183]
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Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL

 MP:0002581 abnormal ileum morphology "malformation of the portion of the small intestine that extends from the jejunum to the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183]
Show

Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL

 MP:0003271 abnormal duodenum morphology "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL

 MP:0003293 rectal hemorrhage "bleeding in the rectum" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009308 adenocarcinoma "malignant neoplasm of epithelial cells in a glandular or glandular-like pattern" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009311 duodenum adenocarcinoma "malignant neoplasm of epithelial cells in the duodenum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010279 increased gastrointestinal tumor incidence "greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0012408 increased duodenum glandular epithelium tumor incidence "greater than the expected number of tumors originating in the duodenal glandular epithelium in a given population in a given time period" [MGI:csmith]
Show

Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL

Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2

 MP:0013482 abnormal duodenum crypts of Lieberkuhn morphology "any structural anomaly of the intestinal crypts located in the mucosa of the duodenum, the first division of the small intestine that extends from the pyloris to the junction with the jejunum" [MGI:Anna]
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Allelic Composition: B3gnt6tm1Lx/B3gnt6tm1Lx,C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S1/Sv * C57BL/6J * SJL

 MP:0013956 decreased colon length "reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]
Show

Allelic Composition: Kmt2atm1(MLL1/ERT)Divo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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