ENSMUSG00000074817


Mus musculus

Features
Gene ID: ENSMUSG00000074817
  
Biological name :Papolb
  
Synonyms : Papolb / poly(A) polymerase beta
  
Possible biological names infered from orthology : Q9NRJ5
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 142525838
Gene end: 142530076
  
Corresponding Affymetrix probe sets: 10535329 (MoGene1.0st)   1449208_at (Mouse Genome 430 2.0 Array)   1456915_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000100595
NCBI entrez gene - 56522     See in Manteia.
MGI - MGI:1932115
RefSeq - NM_019943
RefSeq Peptide - NP_064327
swissprot - A1L349
Ensembl - ENSMUSG00000074817
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 papolaENSDARG00000009585Danio rerio
 PAPOLAENSGALG00000033099Gallus gallus
 PAPOLBENSG00000218823Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Papola / Q61183 / Poly(A) polymerase alpha / P51003*ENSMUSG0000002111186
Papolg / Q6PCL9 / poly(A) polymerase gamma / Q9BWT3*ENSMUSG0000002027358


Protein motifs (from Interpro)
Interpro ID Name
 IPR002934  Polymerase, nucleotidyl transferase domain
 IPR007010  Poly(A) polymerase, RNA-binding domain
 IPR007012  Poly(A) polymerase, central domain
 IPR011068  Nucleotidyltransferase, class I-like, C-terminal
 IPR014492  Poly(A) polymerase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0031123 RNA 3"-end processing IEA
 biological_processGO:0043631 RNA polyadenylation IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004652 polynucleotide adenylyltransferase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Blnktm1Pjln/Blnktm1Pjln,Btktm1Wk/Btktm1Wk
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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