Manteia

ENSMUSG00000074852

Mus musculus

Features

Gene ID:	ENSMUSG00000074852

Biological name :	Hpse2

Synonyms :	B2RY83 / Hpse2 / Inactive heparanase-2

Possible biological names infered from orthology :	heparanase 2 (inactive) / Q8WWQ2

Species:	Mus musculus

Chr. number:	19
Strand:	-1
Band:	C3
Gene start:	42788947
Gene end:	43388311

Corresponding Affymetrix probe sets:	10467826 (MoGene1.0st)

Cross references:	Ensembl peptide - ENSMUSP00000097026 NCBI entrez gene - 545291 See in Manteia. MGI - MGI:2685814 RefSeq - XM_011247295 RefSeq - NM_001081257 RefSeq - XM_006527214 RefSeq - XM_011247294 RefSeq Peptide - NP_001074726 swissprot - B2RY83 Ensembl - ENSMUSG00000074852

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
HPSE2	ENSG00000172987	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Hpse / Q6YGZ1 / Heparanase Heparanase 8 kDa subunit Heparanase 50 kDa subunit / Q9Y251* / heparanase*	ENSMUSG00000035273	40

Protein motifs (from Interpro)

Interpro ID	Name
IPR005199	Glycoside hydrolase, family 79
IPR017853	Glycoside hydrolase superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0008284	positive regulation of cell proliferation	IMP
biological_process	GO:0030198	extracellular matrix organization	IMP
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005622	intracellular	IBA
cellular_component	GO:0016020	membrane	IEA
molecular_function	GO:0016798	hydrolase activity, acting on glycosyl bonds	IEA
molecular_function	GO:0043395	heparan sulfate proteoglycan binding	IEA

Pathways (from Reactome)

Pathway description

HS-GAG degradation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000477	abnormal intestine morphology	"malformation of the digestive tube passing from the stomach to the anus" [J:48968]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0000539	distended urinary bladder	"stretched musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0001761	abnormal urination pattern	"increased or decreased frequency of urination" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0002871	albuminuria	"presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0002962	increased protein excretion	"greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0002989	small kidney	"reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0003280	urinary incontinence	"inability to control the urinary excretory functions" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0005419	hypoalbuminemia	"blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0010386	abnormal urinary bladder physiology	"any functional anomaly of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0011084	partial lethality at weaning	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0011535	increased urination frequency	"increased frequency of urination episodes; urination at short frequent intervals occurs without an increase in daily volume of urinary output and may be caused by reduced bladder capacity or urinary tract infection" [MGI:anna]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6
MP:0011769	urinary bladder fibrosis	"invasion of fibrous connective tissue into the urinary bladder, often resulting from inflammation or injury" [MGI:anna]	Show Allelic Composition: Tor1a^tm2Wtd/Tor1a^tm4.2Wtd Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr