Manteia

ENSMUSG00000075588

Mus musculus

Features

Gene ID:	ENSMUSG00000075588

Biological name :	Hoxb2

Synonyms :	Homeobox protein Hox-B2 / Hoxb2 / P0C1T1

Possible biological names infered from orthology :	homeobox B2 / P14652

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	D
Gene start:	96350525
Gene end:	96354012

Corresponding Affymetrix probe sets:	10380660 (MoGene1.0st) 1449397_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000098092 NCBI entrez gene - 103889 See in Manteia. MGI - MGI:96183 RefSeq - NM_134032 RefSeq Peptide - NP_598793 swissprot - P0C1T1 Ensembl - ENSMUSG00000075588

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
HOXB2	ENSGALG00000025774	Gallus gallus
HOXB2	ENSG00000173917	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Hoxa2 / P31245 / Homeobox protein Hox-A2 / O43364* / homeobox A2*	ENSMUSG00000014704	49
Hoxb3 / P09026 / Homeobox protein Hox-B3 / P14651* / homeobox B3*	ENSMUSG00000048763	29
Hoxa3 / P02831 / Homeobox protein Hox-A3 / O43365* / homeobox A3*	ENSMUSG00000079560	28
Hoxd3 / P09027 / homeobox D3 / P31249*	ENSMUSG00000079277	25
Pdx1 / P52946 / Pancreas/duodenum homeobox protein 1 / P52945* / pancreatic and duodenal homeobox 1*	ENSMUSG00000029644	23
Hoxd1 / Q01822 / Homeobox protein Hox-D1 / Q9GZZ0* / homeobox D1*	ENSMUSG00000042448	21
Hoxb1 / P17919 / Homeobox protein Hox-B1 / P14653* / homeobox B1*	ENSMUSG00000018973	20
Hoxa1 / homeobox A1 / P49639*	ENSMUSG00000029844	20
Gsx2 / P31316 / GS homeobox 2 / Q9BZM3*	ENSMUSG00000035946	19
Gsx1 / P31315 / GS homeobox 1 / Q9H4S2*	ENSMUSG00000053129	19
Gm28308	ENSMUSG00000101298	3

Protein motifs (from Interpro)

Interpro ID	Name
IPR001356	Homeobox domain
IPR001827	Homeobox protein, antennapedia type, conserved site
IPR009057	Homeobox-like domain superfamily
IPR017970	Homeobox, conserved site
IPR020479	Homeobox domain, metazoa

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002011	morphogenesis of an epithelial sheet	IGI
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0009952	anterior/posterior pattern specification	IMP
biological_process	GO:0009953	dorsal/ventral pattern formation	IGI
biological_process	GO:0021569	rhombomere 3 development	IGI
biological_process	GO:0021570	rhombomere 4 development	IGI
biological_process	GO:0021612	facial nerve structural organization	IMP
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0048704	embryonic skeletal system morphogenesis	IGI
biological_process	GO:0048705	skeletal system morphogenesis	IMP
biological_process	GO:0048857	neural nucleus development	IMP
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0016607	nuclear speck	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	ISO

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000042	abnormal organ of Corti	"abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hoxb2^tm3.1Fmr/Hoxb2^tm3.1Fmr Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000157	abnormal sternum morphology	"malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]	Show Allelic Composition: Hoxb2^tm1Mrc/Hoxb2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000843	absent facial nuclei	"missing nucleus of neurons in the hindbrain; receives fibers from the facial muscles, stapedus muscle and stylohyoid muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Hoxa2^tm1Ipc/Hoxa2^tm1Ipc,Hoxb2^tm1Fmr/Hoxb2^tm1Fmr Genetic Background: involves: 129/Sv * 129S2/SvPas Allelic Composition: Hoxb2^tm1Mrc/Hoxb2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0000848	abnormal pons	"malformed band of nerve fibers in the brain connecting the medulla oblongata and the mesencephalon; this region conveys information about movement from the cerebral hemisphere to the cerebellum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:1776, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Hoxb2^tm3.1Fmr/Hoxb2^tm3.1Fmr Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000913	abnormal brain development	"malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]	Show Allelic Composition: Hoxa2^tm1.1Fmr/Hoxa2^tm1.1Fmr,Tg(CAG-cre/ERT2)F34Fmr/0 Genetic Background: involves: 129 * CD-1 Allelic Composition: Hoxa2^tm2.1Fmr/Hoxa2^tm2.1Fmr,Hoxb2^tm2.2Fmr/Hoxb2^tm2.2Fmr Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0000933	abnormal rhombomere morphology	"malformation of the transverse segments in the hindbrain region of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Gopc^tm1.1Tno/Gopc^tm1.1Tno Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000954	reduced oligodendrocyte progenitor number	"fewer cells that differentiate into a type of glial cell in the central nervous system" [J:15108]	Show Allelic Composition: Hoxa2^tm1.1Fmr/Hoxa2^tm1.1Fmr,Tg(CAG-cre/ERT2)F34Fmr/0 Genetic Background: involves: 129 * CD-1 Allelic Composition: Hoxa2^tm2.1Fmr/Hoxa2^tm2.1Fmr,Hoxb2^tm2.2Fmr/Hoxb2^tm2.2Fmr Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0001071	abnormal facial nerve morphology	"malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]	Show Allelic Composition: Hoxb2^tm1Mrc/Hoxb2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxb2^tm1Mrc/Hoxb2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001083	small geniculate ganglion	"reduced size of the geniculate ganglion or decreased size of sensory neuron cell bodies associated with the facial nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Hoxb2^tm1Mrc/Hoxb2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Hoxa2^tm1Ipc/Hoxa2^tm1Ipc,Hoxb2^tm1Fmr/Hoxb2^tm1Fmr Genetic Background: involves: 129/Sv * 129S2/SvPas
MP:0001386	abnormal maternal nurturing	"failure of mothers to tend offspring" [J:39801]	Show Allelic Composition: Hoxa2^tm1Ipc/Hoxa2^tm1Ipc,Hoxb2^tm1Fmr/Hoxb2^tm1Fmr Genetic Background: involves: 129/Sv * 129S2/SvPas Allelic Composition: Hoxb2^tm1Mrc/Hoxb2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Hoxb2^tm1Mrc/Hoxb2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxb2^tm1Mrc/Hoxb2⁺,Hoxb4^tm1Nrm/Hoxb4⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxa2^tm1Ipc/Hoxa2^tm1Ipc,Hoxb2^tm1Fmr/Hoxb2^tm1Fmr Genetic Background: involves: 129/Sv * 129S2/SvPas Allelic Composition: Hoxb2^tm1Mrc/Hoxb2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(Hoxa2)Fmr}/Gt(ROSA)26Sor⁺,Olig2^{tm2(TVA,cre)Rth}/Olig2⁺ Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Hoxb2^tm3.1Fmr/Hoxb2⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Hoxb2^tm3.1Fmr/Hoxb2^tm3.1Fmr Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0003385	abnormal body wall	"malformation in the external portion of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hoxb2^tm1Mrc/Hoxb2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004320	split sternum	"the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxb2^tm1Mrc/Hoxb2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004322	abnormal sternebra morphology	"any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxb2^tm1Mrc/Hoxb2⁺,Hoxb4^tm1Nrm/Hoxb4⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
MP:0004399	abnormal cochlear outer hair cell morphology	"any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxb2^tm3.1Fmr/Hoxb2^tm3.1Fmr Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0004561	absent facial nerve	"absence of the sensory and motor nerve that supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]	Show Allelic Composition: Hoxb2^tm1Mrc/Hoxb2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004599	abnormal vertebral arch morphology	"any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxb2^tm1Mrc/Hoxb2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0004615	cervical vertebral transformation	"homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxb2^tm1Mrc/Hoxb2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxb2^tm1Mrc/Hoxb2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxb2^tm1Mrc/Hoxb2⁺,Hoxb4^tm1Nrm/Hoxb4⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
MP:0005253	abnormal eye physiology	"anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Hoxb2^tm1Mrc/Hoxb2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0005277	abnormal brainstem morphology	"anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]	Show Allelic Composition: Hoxb2^tm3.1Fmr/Hoxb2^tm3.1Fmr Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0009879	abnormal arcus anterior morphology	"any structural anomaly in the arch that connects the lateral masses of the atlas anteriorly and articulates with the anterior articular facet of the dens of the axis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxb2^tm1Mrc/Hoxb2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxb2^tm1Mrc/Hoxb2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0010892	increased oligodendrocyte progenitor number	"greater number of cells that differentiate into a type of glial cell in the central nervous system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hoxa2^tm2.1Fmr/Hoxa2^tm2.1Fmr,Hoxb2^tm2.2Fmr/Hoxb2^tm2.2Fmr Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Hoxa2^tm1Ipc/Hoxa2^tm1Ipc,Hoxb2^tm1Fmr/Hoxb2^tm1Fmr Genetic Background: involves: 129/Sv * 129S2/SvPas
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Hoxa2^tm1Ipc/Hoxa2^tm1Ipc,Hoxb2^tm1Fmr/Hoxb2^tm1Fmr Genetic Background: involves: 129/Sv * 129S2/SvPas
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Hoxa2^tm1Ipc/Hoxa2^tm1Ipc,Hoxb2^tm1Fmr/Hoxb2^tm1Fmr Genetic Background: involves: 129/Sv * 129S2/SvPas Allelic Composition: Hoxb2^tm1Mrc/Hoxb2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxb2^tm1Mrc/Hoxb2⁺,Hoxb4^tm1Nrm/Hoxb4⁺ Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Hoxb2^tm3.1Fmr/Hoxb2^tm3.1Fmr Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0012285	misaligned sternebrae	"abnormal alignment of the sternebrae along the ventral midline" [MGI:anna]	Show Allelic Composition: Hoxb2^tm1Mrc/Hoxb2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ Allelic Composition: Hoxb2^tm1Mrc/Hoxb2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0012490	abnormal cochlear VIII nucleus morphology	"any structural anomaly of two paired brainstem nuclei, the dorsal cochlear nucleus and the ventral cochlear nucleus, that lie dorsal and ventral, respectively, to the inferior cerebellar peduncle at the rostral pole of the medulla; the cochlear nuclei receive input from the cochlear nerve and send projections to the inferior colliculus, the medial geniculate, and other forebrain structures" [MGI:csmith]	Show Allelic Composition: Hoxb2^tm3.1Fmr/Hoxb2^tm3.1Fmr Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0012524	abnormal lower lip morphology	"any structural anomaly of the muscular fold bounding the opening of the mouth inferiorly" [MGI:anna]	Show Allelic Composition: Hoxb2^tm1Mrc/Hoxb2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0012786	increased rhombomere 1 size	"increased size of the first transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order with the first rhombomere arising next to the midbrain-hindbrain boundary, or isthmus" [MGI:anna]	Show Allelic Composition: Hoxa2^tm1Ipc/Hoxa2^tm1Ipc,Hoxb2^tm1Fmr/Hoxb2^tm1Fmr Genetic Background: involves: 129/Sv * 129S2/SvPas
MP:0012796	abnormal rhombomere 4 morphology	"any structural anomaly of the fourth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna, MGI:csmith, UBERON:0005511]	Show Allelic Composition: Hoxa2^tm1Ipc/Hoxa2^tm1Ipc,Hoxb2^tm1Fmr/Hoxb2^tm1Fmr Genetic Background: involves: 129/Sv * 129S2/SvPas
MP:0012818	rhombomere transformation	"homeotic transformation of a specific rhombomere to adopt the fate of another" [MGI:csmith]	Show Allelic Composition: Hoxa2^tm1Ipc/Hoxa2^tm1Ipc,Hoxb2^tm1Fmr/Hoxb2^tm1Fmr Genetic Background: involves: 129/Sv * 129S2/SvPas
MP:0030067	narrow face	"a reduction in the width of the upper and lower face" [MGI:anna]	Show Allelic Composition: Hoxb2^tm1Mrc/Hoxb2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0030140	facial muscle atrophy	"acquired diminution of facial muscle tissue associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:anna]	Show Allelic Composition: Hoxb2^tm1Mrc/Hoxb2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0030141	facial paralysis	"complete loss of power of voluntary movement in muscles of the face through injury or disease of it or its nerve supply; facial muscles are innervated by the facial nerve (i.e., the seventh cranial nerve)" [MGI:anna]	Show Allelic Composition: Hoxb2^tm1Mrc/Hoxb2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0030430	absent levator nasolabialis muscle	"missing the flat, thin muscle that lies beneath the skin on the lateral surface of the maxillary bone; it arises from the maxillary bone, over the dorsum of the nose, and runs cranioventrally to insert partly on the wing of the nostril and partly into the lateral part of the upper lip; it acts to dilate the nostrils and elevate and retract the upper lip" [MGI:anna]	Show Allelic Composition: Hoxb2^tm1Mrc/Hoxb2^tm1Mrc Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr