ENSMUSG00000078202


Mus musculus

Features
Gene ID: ENSMUSG00000078202
  
Biological name :Nrarp
  
Synonyms : Notch-regulated ankyrin repeat-containing protein / Nrarp / Q91ZA8
  
Possible biological names infered from orthology : NOTCH regulated ankyrin repeat protein / Q7Z6K4
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 25180758
Gene end: 25183339
  
Corresponding Affymetrix probe sets: 10469936 (MoGene1.0st)   1417985_at (Mouse Genome 430 2.0 Array)   1417986_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000100615
NCBI entrez gene - 67122     See in Manteia.
MGI - MGI:1914372
RefSeq - NM_025980
RefSeq Peptide - NP_080256
swissprot - Q91ZA8
Ensembl - ENSMUSG00000078202
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrarpaENSDARG00000091419Danio rerio
 NRARPENSGALG00000027231Gallus gallus
 NRARPENSG00000198435Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9D119 / Ppp1r27 / Protein phosphatase 1 regulatory subunit 27 / Q86WC6*ENSMUSG0000002512932
Q9DBR7 / Ppp1r12a / protein phosphatase 1, regulatory (inhibitor) subunit 12A / O14974* / protein phosphatase 1 regulatory subunit 12A*ENSMUSG0000001990730
Q3UMT1 / Ppp1r12c / Protein phosphatase 1 regulatory subunit 12C / Q9BZL4*ENSMUSG0000001925429
Q923M0 / Ppp1r16a / protein phosphatase 1, regulatory (inhibitor) subunit 16A / Q96I34* / protein phosphatase 1 regulatory subunit 16A*ENSMUSG0000003381926
Q8BG95 / Ppp1r12b / protein phosphatase 1, regulatory (inhibitor) subunit 12B / O60237* / protein phosphatase 1 regulatory subunit 12B*ENSMUSG0000007355726
Q8VHQ3 / Ppp1r16b / protein phosphatase 1, regulatory (inhibitor) subunit 16B / Q96T49* / protein phosphatase 1 regulatory subunit 16B*ENSMUSG0000003775425
Trp53bp2 / transformation related protein 53 binding protein 2 / Q13625* / TP53BP2* / tumor protein p53 binding protein 2*ENSMUSG0000002651014
Q62415 / Ppp1r13b / protein phosphatase 1, regulatory (inhibitor) subunit 13B / Q96KQ4* / protein phosphatase 1 regulatory subunit 13B*ENSMUSG0000002128512
Q5I1X5 / Ppp1r13l / protein phosphatase 1, regulatory (inhibitor) subunit 13 like / Q8WUF5* / protein phosphatase 1 regulatory subunit 13 like*ENSMUSG000000407345


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0001569 branching involved in blood vessel morphogenesis ISS
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IMP
 biological_processGO:0002040 sprouting angiogenesis ISS
 biological_processGO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0022407 regulation of cell-cell adhesion ISS
 biological_processGO:0032525 somite rostral/caudal axis specification IMP
 biological_processGO:0045581 negative regulation of T cell differentiation IDA
 biological_processGO:0045746 negative regulation of Notch signaling pathway IEA
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IBA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1902367 negative regulation of Notch signaling pathway involved in somitogenesis IMP
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

Allelic Composition: Nrarptm1Grid/Nrarptm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Nrarptm1Grid/Nrarptm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ

 MP:0000364 abnormal vascular regression "premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: a/a,Mssq7KK/TaJcl/?
Genetic Background: involves: C57BL/6JJcl * KK/TaJcl

Allelic Composition: Nrarptm1Vlcg/Nrarp+
Genetic Background: involves: C57BL/6J

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

 MP:0000963 fused dorsal root ganglia "loss of DRG spacing pattern and the appearance of two or more ganglia as one " [J:62022, J:62023]
Show

Allelic Composition: Nrarptm1Grid/Nrarptm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ

 MP:0001077 abnormal spinal nerve morphology "any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nrarptm1Grid/Nrarptm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
Show

Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nrarptm1Grid/Nrarptm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: a/a,Mssq7KK/TaJcl/?
Genetic Background: involves: C57BL/6JJcl * KK/TaJcl

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: a/a,Mssq7KK/TaJcl/?
Genetic Background: involves: C57BL/6JJcl * KK/TaJcl

Allelic Composition: Nrarptm1Vlcg/Nrarp+
Genetic Background: involves: C57BL/6J

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrarptm1Grid/Nrarptm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Nrarptm1Grid/Nrarptm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ

 MP:0004612 fusion of vertebral bodies "improper union of the main cylindrical portion of adjacent vertebra ventral to the vertebral canal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrarptm1Grid/Nrarptm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

 MP:0004619 caudal vertebral fusion "the union of one or more caudal vertebrae into a single structure in species where this does not normally occur" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrarptm1Grid/Nrarptm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Nrarptm1Grid/Nrarptm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ

 MP:0004621 lumbar vertebral fusion "the union of one or more lumbar vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrarptm1Grid/Nrarptm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Nrarptm1Grid/Nrarptm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ

 MP:0004622 sacral vertebral fusion "the union of one or more sacral vertebrae into a single structure in species where this does not normally occur" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrarptm1Grid/Nrarptm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Nrarptm1Grid/Nrarptm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ

 MP:0004623 thoracic vertebral fusion "the union of one or more thoracic vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nrarptm1Grid/Nrarptm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Allelic Composition: Nrarptm1Grid/Nrarptm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

 MP:0005223 abnormal anterior-posterior polarity of the somites "anomalous development or formation of the somites along the axis that runs from the front to the back surface of the body " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:72325]
Show

Allelic Composition: Nrarptm1Grid/Nrarptm1Grid
Genetic Background: involves: 129S1/Sv * 129S1/SvImj * 129X1/SvJ

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: a/a,Mssq7KK/TaJcl/?
Genetic Background: involves: C57BL/6JJcl * KK/TaJcl

Allelic Composition: Nrarptm1Vlcg/Nrarp+
Genetic Background: involves: C57BL/6J

 MP:0009660 abnormal induced retinal neovascularization "any anomaly in the response to conditions which induce the pathological growth of vessels into the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dll4tm2.1Vlcg/Dll4+,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6NTac

 MP:0012670 prolonged somite segmentation clock period "extension of the somite segmentation clock period; may lead to decreased numbers of somites and their resultant vertebrae" [MGI:anna]
Show

Allelic Composition: Cspg4tm1Ychan/Cspg4tm1Ychan,Olig2tm2(TVA,cre)Rth/Olig2+
Genetic Background: involves: 129 * C57BL/6N

 MP:0020316 decreased vascular endothelial cell proliferation "decrease in the expansion rate of any vascular endothelial cell population by cell division" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: a/a,Mssq7KK/TaJcl/?
Genetic Background: involves: C57BL/6JJcl * KK/TaJcl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr