ENSMUSG00000079298


Mus musculus

Features
Gene ID: ENSMUSG00000079298
  
Biological name :Klrb1b
  
Synonyms : Killer cell lectin-like receptor subfamily B member 1B allele B / Klrb1b / Q99JB4
  
Possible biological names infered from orthology : killer cell lectin like receptor B1 / KLRB1 / Q12918
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F3
Gene start: 128813706
Gene end: 128826331
  
Corresponding Affymetrix probe sets: 10548314 (MoGene1.0st)   1420421_s_at (Mouse Genome 430 2.0 Array)   1422065_at (Mouse Genome 430 2.0 Array)   1422066_x_at (Mouse Genome 430 2.0 Array)   1422067_at (Mouse Genome 430 2.0 Array)   1445399_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144964
Ensembl peptide - ENSMUSP00000032472
Ensembl peptide - ENSMUSP00000134022
Ensembl peptide - ENSMUSP00000134637
NCBI entrez gene - 80782     See in Manteia.
MGI - MGI:107539
RefSeq - XM_006506796
RefSeq - NM_030599
RefSeq Peptide - NP_085102
swissprot - G3UZU5
swissprot - A0A1U9W1A4
swissprot - A0A0N4SV58
swissprot - Q99JB4
swissprot - G3UYB9
Ensembl - ENSMUSG00000079298
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BLEC2ENSGALG00000000136Gallus gallus
 KLRB1ENSG00000111796Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm44511 / KLRB1* / Q12918* / killer cell lectin like receptor B1*ENSMUSG0000010787291
Klrb1c / KLRB1* / Q12918* / killer cell lectin like receptor B1*ENSMUSG0000003032573
Klrb1a / KLRB1* / Q12918* / killer cell lectin like receptor B1*ENSMUSG0000003036172
Klrb1 / Q0ZUP1 / Killer cell lectin-like receptor subfamily B member 1 / Q12918* / killer cell lectin like receptor B1*ENSMUSG0000007929951
Klrb1f / Q8VD98 / killer cell lectin-like receptor subfamily B member 1F / KLRB1* / Q12918* / killer cell lectin like receptor B1*ENSMUSG0000003015449


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR033992  Natural killer cell receptor-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0045953 negative regulation of natural killer cell mediated cytotoxicity IGI
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
Show

Allelic Composition: Ctsktm1(cre)Ska/Ctsk+,Plekhm1tm1.1Hzhao/Plekhm1tm1.1Hzhao
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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