ENSMUSG00000090077


Mus musculus

Features
Gene ID: ENSMUSG00000090077
  
Biological name :Lime1
  
Synonyms : Lck-interacting transmembrane adapter 1 / Lime1 / Q9EQR5
  
Possible biological names infered from orthology : AL121845.2 / Lck interacting transmembrane adaptor 1 / Q9H400
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H4
Gene start: 181380078
Gene end: 181383628
  
Corresponding Affymetrix probe sets: 10479607 (MoGene1.0st)   1416869_x_at (Mouse Genome 430 2.0 Array)   1437589_x_at (Mouse Genome 430 2.0 Array)   1448500_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104432
Ensembl peptide - ENSMUSP00000117558
Ensembl peptide - ENSMUSP00000119181
Ensembl peptide - ENSMUSP00000045010
NCBI entrez gene - 72699     See in Manteia.
MGI - MGI:1919949
RefSeq - NM_023684
RefSeq Peptide - NP_076173
swissprot - Q9EQR5
swissprot - A2AU24
swissprot - F6QX71
swissprot - F6ZRC5
Ensembl - ENSMUSG00000090077
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AL121845.2ENSG00000273047Homo sapiens
 LIME1ENSG00000203896Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026072  Lck-interacting transmembrane adapter 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000390 spliceosomal complex disassembly IBA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0043405 regulation of MAP kinase activity IMP
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0050853 B cell receptor signaling pathway IEA
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0019815 B cell receptor complex IDA
 cellular_componentGO:0071008 U2-type post-mRNA release spliceosomal complex IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fbxo4tm1.1Jadi/Fbxo4tm1.1Jadi
Genetic Background: Not Specified

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lime1tm1Mal/Lime1tm1Mal,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/?
Genetic Background: B6.Cg-Rag2tm1Fwa Lime1tm1Mal Tg(TcraH-Y,TcrbH-Y)1Pas

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rspo2tm1Nuv/Rspo2+
Genetic Background: involves: 129 * C57BL/6

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lime1tm1Mal/Lime1tm1Mal,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/?
Genetic Background: B6.Cg-Rag2tm1Fwa Lime1tm1Mal Tg(TcraH-Y,TcrbH-Y)1Pas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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