ENSMUSG00000091055


Mus musculus

Features
Gene ID: ENSMUSG00000091055
  
Biological name :Siglec15
  
Synonyms : sialic acid binding Ig-like lectin 15 / Siglec15
  
Possible biological names infered from orthology : Q6ZMC9
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: E3
Gene start: 78043614
Gene end: 78057395
  
Corresponding Affymetrix probe sets: 10459858 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000126901
NCBI entrez gene - 620235     See in Manteia.
MGI - MGI:3646642
RefSeq - XM_011247092
RefSeq - NM_001101038
RefSeq - XM_006526516
RefSeq - XM_011247091
RefSeq - XM_006526515
RefSeq Peptide - NP_001094508
swissprot - A7E1W8
Ensembl - ENSMUSG00000091055
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-11p23.7ENSDARG00000032743Danio rerio
 SIGLEC15ENSGALG00000039928Gallus gallus
 Q6ZMC9ENSG00000197046Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0032956 regulation of actin cytoskeleton organization IMP
 biological_processGO:0045124 regulation of bone resorption IMP
 biological_processGO:2001204 regulation of osteoclast development IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
DAP12 interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004993 decreased bone resorption "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0010872 increased trabecular bone mass "greater total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0010967 increased compact bone area "increase in the total amount of cross-sectional area of compact bone tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0011922 abnormal circulating osteocalcin level "aberrant concentration in the blood of this hormone secreted by osteoblasts which are found in bone and dentin" [MPD:Molly]
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Allelic Composition: G6pctm1.1Ics/G6pctm1.1Ics,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030579 O54885 / Tyrobp / TYRO protein tyrosine kinase binding protein / O43914*  / complex / reaction






 

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