ENSMUSG00000092118


Mus musculus

Features
Gene ID: ENSMUSG00000092118
  
Biological name :Fancf
  
Synonyms : E9Q5Z5 / Fancf / Fanconi anemia group F protein
  
Possible biological names infered from orthology : Fanconi anemia complementation group F / Q9NPI8
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B4
Gene start: 51860577
Gene end: 51862267
  
Corresponding Affymetrix probe sets: 10563816 (MoGene1.0st)   1435834_at (Mouse Genome 430 2.0 Array)   1438564_at (Mouse Genome 430 2.0 Array)   1446731_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125812
NCBI entrez gene - 100040608     See in Manteia.
MGI - MGI:3689889
RefSeq - NM_001115087
RefSeq Peptide - NP_001108559
swissprot - E9Q5Z5
Ensembl - ENSMUSG00000092118
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fancfENSDARG00000019250Danio rerio
 FANCFENSGALG00000003660Gallus gallus
 FANCFENSG00000183161Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR025825  Fanconi anemia group F protein, metazoa
 IPR035428  Fanconi anemia group F protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0016567 protein ubiquitination IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0043240 Fanconi anaemia nuclear complex ISO
 molecular_functionGO:0061630 ubiquitin protein ligase activity IMP


Pathways (from Reactome)
Pathway description
Fanconi Anemia Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0001751 increased circulating luteinizing hormone level "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0008393 absent primordial germ cells "absence of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0008871 abnormal ovarian follicle number "abnormal numbers of spheroid cell aggregations in the ovary" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0011121 decreased primordial ovarian follicle number "fewer than normal numbers of the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:csmith]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0012411 increased granulosa cell tumor incidence "greater than the expected number of neoplasms derived from somatic cells of the sex cord in the ovary a given population in a given time period" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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