ENSMUSG00000107283


Mus musculus
increasedMpv17leveldegenerationdecreasedcirculatingmitochondrialmembraneprocessrenalreactiveoxygenspeciesproteincochlearkidneyglomerulardevelopmentresponseinnermetabolichairsebaceousglandthinskinweighttubulesdilatedganglioncontent

Features
Gene ID: ENSMUSG00000107283
  
Biological name :Mpv17
  
Synonyms : Mpv17 / P19258 / Protein Mpv17
  
Possible biological names infered from orthology : MPV17, mitochondrial inner membrane protein / P39210
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B1
Gene start: 31140654
Gene end: 31154251
  
Corresponding Affymetrix probe sets: 10529082 (MoGene1.0st)   1420387_at (Mouse Genome 430 2.0 Array)   1441076_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144593
Ensembl peptide - ENSMUSP00000144324
Ensembl peptide - ENSMUSP00000144331
Ensembl peptide - ENSMUSP00000143843
Ensembl peptide - ENSMUSP00000115292
Ensembl peptide - ENSMUSP00000144600
Ensembl peptide - ENSMUSP00000144119
Ensembl peptide - ENSMUSP00000144198
NCBI entrez gene - 17527     See in Manteia.
MGI - MGI:97138
RefSeq - NM_008622
RefSeq - NM_001294322
RefSeq - NM_001294324
RefSeq - NM_001310527
RefSeq - NM_001310528
RefSeq Peptide - NP_001281251
RefSeq Peptide - NP_032648
RefSeq Peptide - NP_001297457
RefSeq Peptide - NP_001297456
RefSeq Peptide - NP_001281253
swissprot - P19258
swissprot - A0A0J9YVC7
swissprot - D3YWI4
swissprot - E9Q1I6
swissprot - F8WHT5
swissprot - G3UVW1
Ensembl - ENSMUSG00000107283
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mpv17ENSDARG00000032431Danio rerio
 MPV17ENSGALG00000026239Gallus gallus
 MPV17ENSG00000115204Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8VIK2 / Mpv17l2 / Mpv17-like protein 2 / Q567V2* / MPV17 mitochondrial inner membrane protein like 2*ENSMUSG0000003555928
Pxmp2 / peroxisomal membrane protein 2 / Q9NR77*ENSMUSG0000002949924


Protein motifs (from Interpro)
Interpro ID Name
 IPR007248  Mpv17/PMP22


Gene Ontology (GO)
cellular component organizationanatomical structure developmentresponse to stressresponse to chemicalcellular response to stimulusregulation of biological qualitycellular metabolic processcellular component organizationanatomical structure developmentresponse to stressresponse to chemicalcellular response to stimulusregulation of biological qualitycellular metabolic processcellular component organizationanatomical structure developmentresponse to stressresponse to chemicalcellular response to stimulusregulation of biological qualitycellular metabolic processcellular component organizationanatomical structure developmentresponse to stressresponse to chemicalcellular response to stimulusregulation of biological qualitycellular metabolic processcellular component organizationanatomical structure developmentresponse to stressresponse to chemicalcellular response to stimulusregulation of biological qualitycellular metabolic processcellular component organizationanatomical structure developmentresponse to stressresponse to chemicalcellular response to stimulusregulation of biological qualitycellular metabolic processcellular component organizationanatomical structure developmentresponse to stressresponse to chemicalcellular response to stimulusregulation of biological qualitycellular metabolic processcellular component organizationanatomical structure developmentresponse to stressresponse to chemicalcellular response to stimulusregulation of biological qualitycellular metabolic processcellular component organizationanatomical structure developmentresponse to stressresponse to chemicalcellular response to stimulusregulation of biological qualitycellular metabolic processcellular component organizationanatomical structure developmentresponse to stressresponse to chemicalcellular response to stimulusregulation of biological qualitycellular metabolic processcellular component ocellular component organizationanatomical structureanatomical structure developmentresponse to stressresponse to stressresponse to chemicalresponse to chemicalcellular response tocellular response to stimulusregulation of biologregulation of biological qualitycellular metabolic pcellular metabolic process
cellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellorganellemembranecellcellorganelleorganellemembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0000002 mitochondrial genome maintenance ISO
 biological_processGO:0032836 glomerular basement membrane development IMP
 biological_processGO:0034614 cellular response to reactive oxygen species IMP
 biological_processGO:0042592 homeostatic process ISO
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:0072593 reactive oxygen species metabolic process IDA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IMP
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane ISO
 cellular_componentGO:0005777 peroxisome IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
hearing/ear phenotypecardiovascular system phenotypeintegument phenotyperenal/urinary system phenotypeliver/biliary system phenotypeendocrine/exocrine gland phenotypegrowth/size phenotypebehavior/neurological phenotypehematopoietic system phenotypepigmentation phenotypemortality/agingnervous system phenotypehomeostasis/metabolism phenotypeskeleton phenotypeadipose tissue phenotypemuscle phenotypecellular phenotypehearing/ear phenotypecardiovascular system phenotypeintegument phenotyperenal/urinary system phenotypeliver/biliary system phenotypeendocrine/exocrine gland phenotypegrowth/size phenotypebehavior/neurological phenotypehematopoietic system phenotypepigmentation phenotypemortality/agingnervous system phenotypehomeostasis/metabolism phenotypeskeleton phenotypeadipose tissue phenotypemuscle phenotypecellular phenotypehearing/ear phenotypecardiovascular system phenotypeintegument phenotyperenal/urinary system phenotypeliver/biliary system phenotypeendocrine/exocrine gland phenotypegrowth/size phenotypebehavior/neurological phenotypehematopoietic system phenotypepigmentation phenotypemortality/agingnervous system phenotypehomeostasis/metabolism phenotypeskeleton phenotypeadipose tissue phenotypemuscle phenotypecellular phenotypehearing/ear phenotypecardiovascular system phenotypeintegument phenotyperenal/urinary system phenotypeliver/biliary system phenotypeendocrine/exocrine gland phenotypegrowth/size phenotypebehavior/neurological phenotypehematopoietic system phenotypepigmentation phenotypemortality/agingnervous system phenotypehomeostasis/metabolism phenotypeskeleton phenotypeadipose tissue phenotypemuscle phenotypecellular phenotypehearing/ear phenotypecardiovascular system phenotypeintegument phenotyperenal/urinary system phenotypeliver/biliary system phenotypeendocrine/exocrine gland phenotypegrowth/size phenotypebehavior/neurological phenotypehematopoietic system phenotypepigmentation phenotypemortality/agingnervous system phenotypehomeostasis/metabolism phenotypeskeleton phenotypeadipose tissue phenotypemuscle phenotypecellular phenotypehearing/ear phenotypecardiovascular system phenotypeintegument phenotyperenal/urinary system phenotypeliver/biliary system phenotypeendocrine/exocrine gland phenotypegrowth/size phenotypebehavior/neurological phenotypehematopoietic system phenotypepigmentation phenotypemortality/agingnervous system phenotypehomeostasis/metabolism phenotypeskeleton phenotypeadipose tissue phenotypemuscle phenotypecellular phenotypehearing/ear phenotypecardiovascular system phenotypeintegument phenotyperenal/urinary system phenotypeliver/biliary system phenotypeendocrine/exocrine gland phenotypegrowth/size phenotypebehavior/neurological phenotypehematopoietic system phenotypepigmentation phenotypemortality/agingnervous system phenotypehomeostasis/metabolism phenotypeskeleton phenotypeadipose tissue phenotypemuscle phenotypecellular phenotypehearing/ear phenotypecardiovascular system phenotypeintegument phenotyperenal/urinary system phenotypeliver/biliary system phenotypeendocrine/exocrine gland phenotypegrowth/size phenotypebehavior/neurological phenotypehematopoietic system phenotypepigmentation phenotypemortality/agingnervous system phenotypehomeostasis/metabolism phenotypeskeleton phenotypeadipose tissue phenotypemuscle phenotypecellular phenotypehearing/ear phenotypecardiovascular system phenotypeintegument phenotyperenal/urinary system phenotypeliver/biliary system phenotypeendocrine/exocrine gland phenotypegrowth/size phenotypebehavior/neurological phenotypehematopoietic system phenotypepigmentation phenotypemortality/agingnervous system phenotypehomeostasis/metabolism phenotypeskeleton phenotypeadipose tissue phenotypemuscle phenotypecellular phenotypehearing/ear phenotypecardiovascular system phenotypeintegument phenotyperenal/urinary system phenotypeliver/biliary system phenotypeendocrine/exocrine gland phenotypegrowth/size phenotypebehavior/neurological phenotypehematopoietic system phenotypepigmentation phenotypemortality/agingnervous system phenotypehomeostasis/metabolism phenotypeskeleton phenotypeadipose tissue phenotypemuscle phenotypecellular phenotypehearing/hearing/ear phenotypecardiovacardiovascular system phenotypeintegumeintegument phenotyperenal/urrenal/urinary system phenotypeliver/biliver/biliary system phenotypeendocrinendocrine/exocrine gland phenotypegrowth/sgrowth/size phenotypebehaviorbehavior/neurological phenotypehematopohematopoietic system phenotypepigmentapigmentation phenotypemortalitmortality/agingnervous nervous system phenotypehomeostahomeostasis/metabolism phenotypeskeletonskeleton phenotypeadipose adipose tissue phenotypemuscle pmuscle phenotypecellularcellular phenotype
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0000523 cortical glomerulopathies "any disease of the capillary plexus in the kidney cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0000647 abnormal sebaceous gland morphology "malformation of the holocrine glands of the dermis that secrete sebum into the hair follicles" [MGI:tc]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0003169 abnormal scala media morphology "any malformation or absence of the division of the spiral canal of the cochlea that contains the organ of Corti (the neuroepithelial receptor organ for hearing)" [J:23837, J:46972, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0003637 cochlear ganglion hypoplasia "reduced numbers of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0004363 stria vascularis degeneration "degeneration or loss of the stratified, secretory epithelium which lines the upper part of the cochlear spiral ligament and maintains potassium ion homeostasis in the endolymph" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0004738 abnormal brainstem auditory evoked potential "anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0004740 sensorineural hearing loss "a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0004864 spiral ligament degeneration "degeneration or loss of the thickened periosteal lining of the bony cochlea that forms the outer wall of the cochlear duct to which the basal lamina attaches" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0005502 abnormal urinary system physiology "functional anomaly of any of the organs involved in the production or excretion of urine " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0008139 fused podocyte foot processes "coalescence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0008140 podocyte foot process effacement "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0008987 abnormal liver lobule morphology "any structural anomaly of the polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0008989 abnormal liver sinusoid morphology "any structural anomaly of the hepatic distensible vascular blood channels lined with highly fenestrated endothelial cells that function to exchange fluids, nutrients, proteins and wastes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0008993 abnormal portal triad morphology "any structural anomaly of the three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0009641 kidney degeneration "a retrogressive impairment of function or destruction of either or both of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0010090 increased circulating creatine kinase level "an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0011157 abnormal hypodermis muscle layer morphology "any structural anomaly of the skeletal muscle layer in the superficial fascia" [ISBN:0-683-40008-8]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0011632 dilated mitochondria "the luminal space of the mitochondria is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0011635 abnormal mitochondrial crista morphology "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0011639 decreased mitochondrial DNA content "less than expected amount of DNA contained within the mirochondria of a eukaryotic cell" [MGI:csmith]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0012725 small sebaceous gland "decreased size of the sebum secreting glands of the hair shaft" [MGI:mnk]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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