Manteia - Molecule gene

ENSMUSG00000115958

Mus musculus

Features

Gene ID:	ENSMUSG00000115958

Biological name :	Kiss1

Synonyms :	Kiss1 / Metastasis-suppressor KiSS-1 Metastin Kisspeptin-10 / Q6Y4S4

Possible biological names infered from orthology :	KiSS-1 metastasis suppressor / Q15726

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	E4
Gene start:	133309827
Gene end:	133329722

Corresponding Affymetrix probe sets:	10349913 (MoGene1.0st)

Cross references:	Ensembl peptide - ENSMUSP00000141501 Ensembl peptide - ENSMUSP00000142234 Ensembl peptide - ENSMUSP00000142264 NCBI entrez gene - 280287 See in Manteia. MGI - MGI:5547776 MGI - MGI:2663985 RefSeq - XM_006529679 swissprot - Q6Y4S4 swissprot - I0J0X7 Ensembl - ENSMUSG00000115958

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
KISS1	ENSG00000170498	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Kiss1 / Q6Y4S4 / Metastasis-suppressor KiSS-1 Metastin Kisspeptin-10 / Q15726* / KiSS-1 metastasis suppressor*	ENSMUSG00000116158	100

Protein motifs (from Interpro)

Interpro ID	Name
IPR020207	Metastasis-suppressor KiSS-1

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IDA
biological_process	GO:0046697	decidualization	IMP
cellular_component	GO:0005576	extracellular region	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000618	small salivary gland	"reduced size of the saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0000639	abnormal adrenal gland morphology	"malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0000653	abnormal sex gland morphology	"anomalous structure of any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0001119	abnormal female reproductive anatomy	"anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3 Allelic Composition: Kiss1^tm1Rla/Kiss1^tm1Rla Genetic Background: involves: 129S1/SvImJ
MP:0001127	small ovary	"reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0001131	abnormal ovarian follicles	"malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0001132	absent mature ovarian follicles	"failure of ovarian follicle differentiation" [J:35782]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0001134	absent corpora lutea	"missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3 Allelic Composition: Kiss1^tm1Rla/Kiss1^tm1Rla Genetic Background: involves: 129S1/SvImJ Allelic Composition: Esr1^tm1.2Awo/Esr1^tm1.2Awo,Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0001140	abnormal vaginal epithelium	"malformation of the epithelial layer of the vagina" [J:54637, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Kiss1^tm1Rla/Kiss1^tm1Rla Genetic Background: involves: 129S1/SvImJ
MP:0001142	abnormal vaginal opening	"a malformed or absent opening to the genital canal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0001145	abnormal male reproductive anatomy	"anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3 Allelic Composition: Kiss1^tm1Rla/Kiss1^tm1Rla Genetic Background: involves: 129S1/SvImJ
MP:0001156	abnormal spermatogenesis	"incomplete maturation or aberrant formation of the male gametes" [J:58959]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0001260	increased body weight	"greater than normal average weight " [J:33400]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺,Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0001751	increased circulating luteinizing hormone level	"higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Esr1^tm1.2Awo/Esr1^tm1.2Awo,Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Kiss1^tm1Rla/Kiss1^tm1Rla Genetic Background: involves: 129S1/SvImJ
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Kiss1^tm1Rla/Kiss1^tm1Rla Genetic Background: involves: 129S1/SvImJ Allelic Composition: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺,Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
MP:0001927	abnormal oestrous cycle (sensu Rodentia)	"failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Tert^tm2.1Rdp/Tert^tm2.1Rdp Genetic Background: involves: C57BL/6 Allelic Composition: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺,Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
MP:0001929	abnormal gametogenesis	"defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0001932	abnormal spermiogenesis	"failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0002016	ovarian cysts	"cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Kiss1^tm1Rla/Kiss1^tm1Rla Genetic Background: involves: 129S1/SvImJ
MP:0002163	abnormal gland morphology	"abnormal development of any glandular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0002636	delayed vaginal opening	"the opening of the genital canal in a female occuring at a later than expected age" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kiss1^tm1Rla/Kiss1^tm1Rla Genetic Background: involves: 129S1/SvImJ
MP:0002637	small uterus	"reduced size of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0002716	small preputial glands	"reduced size of the sebaceous glands of the corona and neck of the glans penis" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, il:Ira Lu , Mouse Genome Informatics Curator, J:82312]	Show Allelic Composition: Kiss1^tm1Rla/Kiss1^tm1Rla Genetic Background: involves: 129S1/SvImJ
MP:0002717	abnormal preputial gland morphology	"anomalous structure of the sebaceous glands of the corona and neck of the glans penis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0002773	decreased circulating luteinizing hormone level	"lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3 Allelic Composition: Esr1^tm1.2Awo/Esr1^tm1.2Awo,Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0002777	absent ovarian follicles	"lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Kiss1^tm1Rla/Kiss1^tm1Rla Genetic Background: involves: 129S1/SvImJ
MP:0002780	decreased circulating testosterone level	"less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0002790	decreased circulating follicle stimulating hormone level	"less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3 Allelic Composition: Kiss1^tm1Rla/Kiss1^tm1Rla Genetic Background: involves: 129S1/SvImJ
MP:0003379	absent sexual maturation	"failure to initiate pubertal changes that result in achievement of full sexual capacity" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0003402	decreased liver weight	"reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0003531	abnormal vagina development	"abnormal morphogenesis of the female reproductive canal located between the uterus and the vulva" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Gt(ROSA)26Sor^tm1(DTA)Riet/Gt(ROSA)26Sor⁺,Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6J
MP:0003572	abnormal uterus development	"abnormal morphogenesis of the female muscular organ of gestation" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0003918	decreased kidney weight	"reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0004109	abnormal Sertoli cell development	"anomalous differentiation of cells that support germ cell differentiation in males" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0004852	decreased testis weight	"reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3 Allelic Composition: Kiss1^tm1Rla/Kiss1^tm1Rla Genetic Background: involves: 129S1/SvImJ
MP:0004856	decreased ovary weight	"reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kiss1^tm1Rla/Kiss1^tm1Rla Genetic Background: involves: 129S1/SvImJ Allelic Composition: Gt(ROSA)26Sor^tm1(DTA)Riet/Gt(ROSA)26Sor⁺,Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6J
MP:0004905	decreased uterus weight	"reduction in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0005148	seminal gland hypoplasia	"reduction in size, usually due to a reduction in cell number, of one of the two folded, sac shaped glands that is a diverticulum of the ductus deferens" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64337]	Show Allelic Composition: Kiss1^tm1Rla/Kiss1^tm1Rla Genetic Background: involves: 129S1/SvImJ
MP:0005159	azoospermia	"absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0005181	decreased circulating estradiol level	"less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0005183	abnormal circulating estradiol level	"aberration in the blood concentration of this most potent estrogen" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0005188	small penis	"in comparison to the norm, reduced size of the organ of copulation and urination in the male" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0005189	abnormal anogenital distance	"in comparison to the norm, aberration in the measure of the length of space from the genitals to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kiss1^tm1Rla/Kiss1^tm1Rla Genetic Background: involves: 129S1/SvImJ
MP:0005536	Leydig cell hypoplasia	"reduced numbers of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Kiss1^tm1Rla/Kiss1^tm1Rla Genetic Background: involves: 129S1/SvImJ
MP:0006380	abnormal spermatid morphology	"anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kiss1^tm1Rla/Kiss1^tm1Rla Genetic Background: involves: 129S1/SvImJ
MP:0008297	retention of the x-zone	"failure of the transient cortical layer juxtaposed to the medulla and the zona reticularis to degenerate after puberty in males or after pregnancy in females" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:3582592]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0008869	anovulation	"complete failure of ovum to be released from an ovarian follicle" [MESH:C13.351.500.056.630.050, MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3
MP:0008948	decreased neuron number	"fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺,Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
MP:0008994	early vaginal opening	"the opening of the genital canal in a female occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Esr1^tm1.2Awo/Esr1^tm1.2Awo,Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0009009	absent estrous cycle	"failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3 Allelic Composition: Kiss1^tm1Rla/Kiss1^tm1Rla Genetic Background: involves: 129S1/SvImJ
MP:0009011	prolonged diestrus	"increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Esr1^tm1.2Awo/Esr1^tm1.2Awo,Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL Allelic Composition: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺,Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
MP:0009017	prolonged estrus	"increase in the length of the estrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺,Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL
MP:0009444	ovarian follicular cyst	"a sac filled with fluid that may develop when the structure containing the egg fails to break open at the time of ovulation" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Esr1^tm1.2Awo/Esr1^tm1.2Awo,Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0013317	abnormal seminal vesicle development	"aberrant or incomplete differentiation of either of the paired sac-like glandular structures situated posterolateral to the urinary bladder in the male and functioning as part of the reproductive system; seminal vesicles develop from the segments of the Wolffian ducts immediately adjacent to the urogenital sinus" [MGI:Anna]	Show Allelic Composition: Kit^Mhdasow3/Kit⁺ Genetic Background: C3HeB/FeJ-Kit^Mhdasow3

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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