ENSMUSG00000116429


Mus musculus

Features
Gene ID: ENSMUSG00000116429
  
Biological name :AC144852.1
  
Synonyms : AC144852.1
  
Possible biological names infered from orthology : AC022506.1
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D3
Gene start: 127290829
Gene end: 127293753
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSMUSP00000155363
MGI - MGI:109247
Ensembl - ENSMUSG00000116429
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AC022506.1ENSG00000285133Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
No match


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Ddit3tm2.1Dron/Ddit3tm2.1Dron,Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Ddit3tm2.1Dron/Ddit3tm2.1Dron,Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tg(TNFSF11)5516Edou/0,Tnfsf11tles/Tnfsf11tles
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0002176 high brain weight "greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm3Wahl/Trp53tm3Wahl
Genetic Background: involves: 129

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ddit3tm1.1Irt/Ddit3tm1.1Irt,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(Mup3-Plau)350-2Eps/?
Genetic Background: involves: C57BL/6 * DBA

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Trp53tm3Wahl/Trp53tm3Wahl
Genetic Background: involves: 129S4/SvJae

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptch1tm1Yy/Ptch1+,Trp53tm1Brd/Trp53+,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a4tm1Abel/Slc2a4tm1Abel,Tg(Myhca-cre)1Abel/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Ddit3tm1Dron/Ddit3tm1Dron
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

 MP:0011075 abnormal macrophage activation involved in immune response "anomaly in the process in which a change in morphology and behavior of a macrophage results from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response" [GO:0002281]
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Allelic Composition: Sox2tm4.1Skn/Sox2tm4.1Skn,Tg(Sox2-cre/ERT2)1Skn/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0011081 decreased macrophage apoptosis "reduced incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sox2tm4.1Skn/Sox2tm4.1Skn,Tg(Sox2-cre/ERT2)1Skn/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0013502 decreased fibroblast apoptosis "reduction in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Ddit3tm1Dron/Ddit3tm1Dron
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0020386 adipose tissue inflammation "local accumulation of fluid, plasma proteins, and leukocytes in adipose tissue" [MGI:anna, PMID:24662293, PMID:24695736, PMID:26629401]
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Allelic Composition: Prss8tm1.1Bug/Prss8Gt(IST10122F12)Tigm
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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