120892


Homo sapiens (NCBI)

Features
Gene ID: 120892
  
Biological name :
  
Synonyms : AURA17|DARDARIN|PARK8|RIPK7|ROCO2 / leucine rich repeat kinase 2 / LRRK2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 229584_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - NC_000012.12
RefSeq - XP_005268686.1
RefSeq - XP_011536179.1
RefSeq - XP_011536183.1
RefSeq - XP_011536184.1
RefSeq - XP_016874275.1
RefSeq - XP_016874276.1
RefSeq - XP_016874277.1
RefSeq - XP_016874278.1
RefSeq - XP_024304601.1
RefSeq - 1034577895
RefSeq - NG_011709.1
RefSeq - 1034577897
RefSeq - NP_940980.3
RefSeq - 1034577899
RefSeq - 1034577902
RefSeq - 1370461153
RefSeq - 171846278
RefSeq - 530399725
RefSeq - 767973113
RefSeq - 767973121
RefSeq - 767973123
RefSeq - XR_001748574.2
RefSeq - NM_198578.3
RefSeq - XM_005268629.4
RefSeq - XM_011537877.3
RefSeq - XM_011537881.3
RefSeq - XM_011537882.3
RefSeq - XM_017018786.2
RefSeq - XM_017018787.1
RefSeq - XM_017018788.2
RefSeq - XM_017018789.2
RefSeq - XM_024448833.1
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000188906 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IDA
 biological_processGO:0000186 activation of MAPKK activity IDA
 biological_processGO:0000187 activation of MAPK activity IMP
 biological_processGO:0001933 negative regulation of protein phosphorylation ISS
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0006468 protein phosphorylation IMP
 biological_processGO:0006897 endocytosis IMP
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006979 response to oxidative stress IMP
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0007030 Golgi organization IMP
 biological_processGO:0007040 lysosome organization IMP
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007528 neuromuscular junction development IMP
 biological_processGO:0008340 determination of adult lifespan IMP
 biological_processGO:0009267 cellular response to starvation IMP
 biological_processGO:0010506 regulation of autophagy IMP
 biological_processGO:0010508 positive regulation of autophagy ISS
 biological_processGO:0010738 regulation of protein kinase A signaling ISS
 biological_processGO:0010955 negative regulation of protein processing IDA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0014041 regulation of neuron maturation IMP
 biological_processGO:0016242 negative regulation of macroautophagy IMP
 biological_processGO:0016310 phosphorylation IMP
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IMP
 biological_processGO:0019722 calcium-mediated signaling IMP
 biological_processGO:0021756 striatum development IEA
 biological_processGO:0021772 olfactory bulb development IMP
 biological_processGO:0022028 tangential migration from the subventricular zone to the olfactory bulb IMP
 biological_processGO:0031398 positive regulation of protein ubiquitination IDA
 biological_processGO:0032091 negative regulation of protein binding IMP
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IEA
 biological_processGO:0034260 negative regulation of GTPase activity IDA
 biological_processGO:0034599 cellular response to oxidative stress IMP
 biological_processGO:0034613 cellular protein localization ISS
 biological_processGO:0035556 intracellular signal transduction ISS
 biological_processGO:0035564 regulation of kidney size ISS
 biological_processGO:0035640 exploration behavior IMP
 biological_processGO:0035641 locomotory exploration behavior IEA
 biological_processGO:0035751 regulation of lysosomal lumen pH IMP
 biological_processGO:0040012 regulation of locomotion IMP
 biological_processGO:0042391 regulation of membrane potential IMP
 biological_processGO:0043068 positive regulation of programmed cell death IDA
 biological_processGO:0043406 positive regulation of MAP kinase activity IC
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046039 GTP metabolic process IDA
 biological_processGO:0046777 protein autophosphorylation IMP
 biological_processGO:0048312 intracellular distribution of mitochondria IMP
 biological_processGO:0048812 neuron projection morphogenesis IMP
 biological_processGO:0051646 mitochondrion localization IMP
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IEA
 biological_processGO:0051900 regulation of mitochondrial depolarization IMP
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic ISS
 biological_processGO:0060070 canonical Wnt signaling pathway TAS
 biological_processGO:0060079 excitatory postsynaptic potential ISS
 biological_processGO:0060159 regulation of dopamine receptor signaling pathway ISS
 biological_processGO:0060161 positive regulation of dopamine receptor signaling pathway IMP
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway TAS
 biological_processGO:0061001 regulation of dendritic spine morphogenesis ISS
 biological_processGO:0070585 protein localization to mitochondrion TAS
 biological_processGO:0070997 neuron death IMP
 biological_processGO:0071287 cellular response to manganese ion IMP
 biological_processGO:0072593 reactive oxygen species metabolic process IMP
 biological_processGO:0090140 regulation of mitochondrial fission TAS
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IGI
 biological_processGO:0090394 negative regulation of excitatory postsynaptic potential ISS
 biological_processGO:0140058 neuron projection arborization IEA
 biological_processGO:1900244 positive regulation of synaptic vesicle endocytosis IEA
 biological_processGO:1901214 regulation of neuron death IMP
 biological_processGO:1901215 negative regulation of neuron death IGI
 biological_processGO:1901727 positive regulation of histone deacetylase activity IEA
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
 biological_processGO:1902499 positive regulation of protein autoubiquitination IDA
 biological_processGO:1902692 regulation of neuroblast proliferation IMP
 biological_processGO:1902803 regulation of synaptic vesicle transport TAS
 biological_processGO:1902823 negative regulation of late endosome to lysosome transport TAS
 biological_processGO:1902902 negative regulation of autophagosome assembly IMP
 biological_processGO:1903125 negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation IDA
 biological_processGO:1903206 negative regulation of hydrogen peroxide-induced cell death IMP
 biological_processGO:1903215 negative regulation of protein targeting to mitochondrion IDA
 biological_processGO:1903217 negative regulation of protein processing involved in protein targeting to mitochondrion IC
 biological_processGO:1903351 cellular response to dopamine IMP
 biological_processGO:1903980 positive regulation of microglial cell activation IEA
 biological_processGO:1904469 positive regulation of tumor necrosis factor secretion IEA
 biological_processGO:1904887 Wnt signalosome assembly TAS
 biological_processGO:1905279 regulation of retrograde transport, endosome to Golgi IGI
 biological_processGO:1905289 regulation of CAMKK-AMPK signaling cascade IMP
 biological_processGO:2000172 regulation of branching morphogenesis of a nerve IMP
 biological_processGO:2000300 regulation of synaptic vesicle exocytosis IMP
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005622 intracellular IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane ISS
 cellular_componentGO:0005743 mitochondrial inner membrane ISS
 cellular_componentGO:0005759 mitochondrial matrix ISS
 cellular_componentGO:0005764 lysosome ISS
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005794 Golgi apparatus ISS
 cellular_componentGO:0005798 Golgi-associated vesicle IDA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0016234 inclusion body IMP
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0030426 growth cone IDA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle ISS
 cellular_componentGO:0031966 mitochondrial membrane IDA
 cellular_componentGO:0032473 cytoplasmic side of mitochondrial outer membrane IDA
 cellular_componentGO:0032839 dendrite cytoplasm IDA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043195 terminal bouton TAS
 cellular_componentGO:0043204 perikaryon ISS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0044753 amphisome IDA
 cellular_componentGO:0044754 autolysosome IDA
 cellular_componentGO:0045121 membrane raft IBA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0097487 multivesicular body, internal vesicle IDA
 cellular_componentGO:0098794 postsynapse IEA
 cellular_componentGO:0099400 caveola neck IDA
 cellular_componentGO:1990904 ribonucleoprotein complex IEA
 cellular_componentGO:1990909 Wnt signalosome NAS
 molecular_functionGO:0000149 SNARE binding IPI
 molecular_functionGO:0003779 actin binding IPI
 molecular_functionGO:0003924 GTPase activity IDA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004708 MAP kinase kinase activity IDA
 molecular_functionGO:0005096 GTPase activator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005525 GTP binding TAS
 molecular_functionGO:0008017 microtubule binding TAS
 molecular_functionGO:0015631 tubulin binding IDA
 molecular_functionGO:0016301 kinase activity IMP
 molecular_functionGO:0017048 Rho GTPase binding IPI
 molecular_functionGO:0017075 syntaxin-1 binding IPI
 molecular_functionGO:0030159 receptor signaling complex scaffold activity IC
 molecular_functionGO:0030276 clathrin binding IPI
 molecular_functionGO:0034211 GTP-dependent protein kinase activity IMP
 molecular_functionGO:0036479 peroxidase inhibitor activity IDA
 molecular_functionGO:0039706 co-receptor binding TAS
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0051018 protein kinase A binding IPI
 molecular_functionGO:1904713 beta-catenin destruction complex binding NAS


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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