12159


Mus musculus (NCBI)

Features
Gene ID: 12159
  
Biological name :
  
Synonyms : Bmp4 / Bmp-4|Bmp2b|Bmp2b-1|Bmp2b1 / bone morphogenetic protein 4
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1422912_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - XP_011243237.1
RefSeq - 568986544
RefSeq - 568986546
RefSeq - 755547702
RefSeq - 755547706
RefSeq - 939320322
RefSeq - NC_000080.6
RefSeq - NP_001303289.1
RefSeq - NP_031580.2
RefSeq - XP_006518530.1
RefSeq - XP_006518531.1
RefSeq - XP_011243236.1
RefSeq - 121949823
RefSeq - NM_001316360.1
RefSeq - NM_007554.3
RefSeq - XM_011244934.2
RefSeq - XM_011244935.2
RefSeq - XM_006518467.3
RefSeq - XM_006518468.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000021835 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0000186 activation of MAPKK activity ISO
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001541 ovarian follicle development ISO
 biological_processGO:0001568 blood vessel development IDA
 biological_processGO:0001649 osteoblast differentiation ISO
 biological_processGO:0001654 eye development IGI
 biological_processGO:0001656 metanephros development IMP
 biological_processGO:0001657 ureteric bud development ISO
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis ISO
 biological_processGO:0001707 mesoderm formation IDA
 biological_processGO:0001759 organ induction IMP
 biological_processGO:0001822 kidney development ISO
 biological_processGO:0001843 neural tube closure IDA
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0001936 regulation of endothelial cell proliferation TAS
 biological_processGO:0001938 positive regulation of endothelial cell proliferation ISO
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0001958 endochondral ossification IMP
 biological_processGO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
 biological_processGO:0002062 chondrocyte differentiation IMP
 biological_processGO:0002244 hematopoietic progenitor cell differentiation ISO
 biological_processGO:0002320 lymphoid progenitor cell differentiation ISO
 biological_processGO:0003014 renal system process IMP
 biological_processGO:0003130 BMP signaling pathway involved in heart induction ISO
 biological_processGO:0003139 secondary heart field specification ISO
 biological_processGO:0003148 outflow tract septum morphogenesis IMP
 biological_processGO:0003149 membranous septum morphogenesis IMP
 biological_processGO:0003150 muscular septum morphogenesis IMP
 biological_processGO:0003151 outflow tract morphogenesis IGI
 biological_processGO:0003180 aortic valve morphogenesis IMP
 biological_processGO:0003184 pulmonary valve morphogenesis IMP
 biological_processGO:0003197 endocardial cushion development IMP
 biological_processGO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation IMP
 biological_processGO:0003215 cardiac right ventricle morphogenesis IMP
 biological_processGO:0003277 apoptotic process involved in endocardial cushion morphogenesis IMP
 biological_processGO:0003323 type B pancreatic cell development ISO
 biological_processGO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis ISO
 biological_processGO:0007182 common-partner SMAD protein phosphorylation ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007281 germ cell development IMP
 biological_processGO:0007492 endoderm development IDA
 biological_processGO:0007500 mesodermal cell fate determination IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0009791 post-embryonic development ISO
 biological_processGO:0009888 tissue development IGI
 biological_processGO:0009948 anterior/posterior axis specification IGI
 biological_processGO:0010159 specification of animal organ position IMP
 biological_processGO:0010453 regulation of cell fate commitment ISO
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010524 positive regulation of calcium ion transport into cytosol ISO
 biological_processGO:0010595 positive regulation of endothelial cell migration TAS
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IGI
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation ISO
 biological_processGO:0010942 positive regulation of cell death ISO
 biological_processGO:0010976 positive regulation of neuron projection development ISO
 biological_processGO:0021537 telencephalon development ISO
 biological_processGO:0021904 dorsal/ventral neural tube patterning IDA
 biological_processGO:0021978 telencephalon regionalization IGI
 biological_processGO:0021983 pituitary gland development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030218 erythrocyte differentiation IDA
 biological_processGO:0030224 monocyte differentiation ISO
 biological_processGO:0030225 macrophage differentiation ISO
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030326 embryonic limb morphogenesis IMP
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0030501 positive regulation of bone mineralization ISO
 biological_processGO:0030509 BMP signaling pathway ISO
 biological_processGO:0030513 positive regulation of BMP signaling pathway IDA
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0032092 positive regulation of protein binding ISO
 biological_processGO:0032331 negative regulation of chondrocyte differentiation IDA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process ISO
 biological_processGO:0033085 negative regulation of T cell differentiation in thymus ISO
 biological_processGO:0033088 negative regulation of immature T cell proliferation in thymus ISO
 biological_processGO:0034504 protein localization to nucleus ISO
 biological_processGO:0034599 cellular response to oxidative stress ISO
 biological_processGO:0035116 embryonic hindlimb morphogenesis IGI
 biological_processGO:0035990 tendon cell differentiation IMP
 biological_processGO:0035993 deltoid tuberosity development IMP
 biological_processGO:0042306 regulation of protein import into nucleus ISO
 biological_processGO:0042326 negative regulation of phosphorylation ISO
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IGI
 biological_processGO:0042476 odontogenesis ISO
 biological_processGO:0042487 regulation of odontogenesis of dentin-containing tooth IGI
 biological_processGO:0042733 embryonic digit morphogenesis IGI
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0043401 steroid hormone mediated signaling pathway ISO
 biological_processGO:0043407 negative regulation of MAP kinase activity ISO
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045165 cell fate commitment IDA
 biological_processGO:0045595 regulation of cell differentiation ISO
 biological_processGO:0045597 positive regulation of cell differentiation IDA
 biological_processGO:0045603 positive regulation of endothelial cell differentiation IDA
 biological_processGO:0045606 positive regulation of epidermal cell differentiation ISO
 biological_processGO:0045662 negative regulation of myoblast differentiation ISO
 biological_processGO:0045666 positive regulation of neuron differentiation ISO
 biological_processGO:0045669 positive regulation of osteoblast differentiation ISO
 biological_processGO:0045778 positive regulation of ossification ISO
 biological_processGO:0045786 negative regulation of cell cycle ISO
 biological_processGO:0045839 negative regulation of mitotic nuclear division ISO
 biological_processGO:0045843 negative regulation of striated muscle tissue development ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048286 lung alveolus development ISO
 biological_processGO:0048333 mesodermal cell differentiation IDA
 biological_processGO:0048392 intermediate mesodermal cell differentiation ISO
 biological_processGO:0048468 cell development IBA
 biological_processGO:0048593 camera-type eye morphogenesis IMP
 biological_processGO:0048598 embryonic morphogenesis IMP
 biological_processGO:0048646 anatomical structure formation involved in morphogenesis IGI
 biological_processGO:0048660 regulation of smooth muscle cell proliferation IDA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation ISO
 biological_processGO:0048663 neuron fate commitment IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0048704 embryonic skeletal system morphogenesis IMP
 biological_processGO:0048706 embryonic skeletal system development IMP
 biological_processGO:0048715 negative regulation of oligodendrocyte differentiation ISO
 biological_processGO:0048745 smooth muscle tissue development IMP
 biological_processGO:0048754 branching morphogenesis of an epithelial tube ISO
 biological_processGO:0050679 positive regulation of epithelial cell proliferation ISO
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IMP
 biological_processGO:0051145 smooth muscle cell differentiation IDA
 biological_processGO:0051150 regulation of smooth muscle cell differentiation IGI
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0055007 cardiac muscle cell differentiation NAS
 biological_processGO:0055020 positive regulation of cardiac muscle fiber development ISO
 biological_processGO:0060113 inner ear receptor cell differentiation IGI
 biological_processGO:0060197 cloacal septation IEP
 biological_processGO:0060235 lens induction in camera-type eye IMP
 biological_processGO:0060272 embryonic skeletal joint morphogenesis IMP
 biological_processGO:0060348 bone development IDA
 biological_processGO:0060363 cranial suture morphogenesis IDA
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction ISO
 biological_processGO:0060393 regulation of pathway-restricted SMAD protein phosphorylation ISO
 biological_processGO:0060395 SMAD protein signal transduction ISO
 biological_processGO:0060425 lung morphogenesis ISO
 biological_processGO:0060429 epithelium development IDA
 biological_processGO:0060433 bronchus development ISO
 biological_processGO:0060438 trachea development ISO
 biological_processGO:0060440 trachea formation IMP
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis ISO
 biological_processGO:0060442 branching involved in prostate gland morphogenesis IMP
 biological_processGO:0060449 bud elongation involved in lung branching IDA
 biological_processGO:0060502 epithelial cell proliferation involved in lung morphogenesis ISO
 biological_processGO:0060503 bud dilation involved in lung branching ISO
 biological_processGO:0060512 prostate gland morphogenesis IMP
 biological_processGO:0060548 negative regulation of cell death ISO
 biological_processGO:0060592 mammary gland formation IMP
 biological_processGO:0060684 epithelial-mesenchymal cell signaling IDA
 biological_processGO:0060686 negative regulation of prostatic bud formation IMP
 biological_processGO:0060687 regulation of branching involved in prostate gland morphogenesis IMP
 biological_processGO:0060688 regulation of morphogenesis of a branching structure IMP
 biological_processGO:0060976 coronary vasculature development IMP
 biological_processGO:0061035 regulation of cartilage development IDA
 biological_processGO:0061036 positive regulation of cartilage development ISO
 biological_processGO:0061047 positive regulation of branching involved in lung morphogenesis IMP
 biological_processGO:0061149 BMP signaling pathway involved in ureter morphogenesis IDA
 biological_processGO:0061151 BMP signaling pathway involved in renal system segmentation IMP
 biological_processGO:0061155 pulmonary artery endothelial tube morphogenesis ISO
 biological_processGO:0061312 BMP signaling pathway involved in heart development IMP
 biological_processGO:0061626 pharyngeal arch artery morphogenesis IMP
 biological_processGO:0070244 negative regulation of thymocyte apoptotic process ISO
 biological_processGO:0070368 positive regulation of hepatocyte differentiation ISO
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0071363 cellular response to growth factor stimulus IDA
 biological_processGO:0071549 cellular response to dexamethasone stimulus ISO
 biological_processGO:0071773 cellular response to BMP stimulus ISO
 biological_processGO:0071893 BMP signaling pathway involved in nephric duct formation ISO
 biological_processGO:0072001 renal system development IGI
 biological_processGO:0072015 glomerular visceral epithelial cell development IEP
 biological_processGO:0072097 negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway ISO
 biological_processGO:0072101 specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway ISO
 biological_processGO:0072104 glomerular capillary formation IMP
 biological_processGO:0072125 negative regulation of glomerular mesangial cell proliferation ISO
 biological_processGO:0072138 mesenchymal cell proliferation involved in ureteric bud development IEP
 biological_processGO:0072161 mesenchymal cell differentiation involved in kidney development IMP
 biological_processGO:0072192 ureter epithelial cell differentiation IMP
 biological_processGO:0072193 ureter smooth muscle cell differentiation IMP
 biological_processGO:0072198 mesenchymal cell proliferation involved in ureter development IEP
 biological_processGO:0072200 negative regulation of mesenchymal cell proliferation involved in ureter development ISO
 biological_processGO:0072205 metanephric collecting duct development IMP
 biological_processGO:0090184 positive regulation of kidney development ISO
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis ISO
 biological_processGO:0090191 negative regulation of branching involved in ureteric bud morphogenesis ISO
 biological_processGO:0090194 negative regulation of glomerulus development ISO
 biological_processGO:1901341 positive regulation of store-operated calcium channel activity ISO
 biological_processGO:1901964 positive regulation of cell proliferation involved in outflow tract morphogenesis IMP
 biological_processGO:1902462 positive regulation of mesenchymal stem cell proliferation ISO
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II ISO
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IGI
 biological_processGO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA ISO
 biological_processGO:1905072 cardiac jelly development IMP
 biological_processGO:1905312 positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis IGI
 biological_processGO:2000005 negative regulation of metanephric S-shaped body morphogenesis ISO
 biological_processGO:2000007 negative regulation of metanephric comma-shaped body morphogenesis ISO
 biological_processGO:2000137 negative regulation of cell proliferation involved in heart morphogenesis ISO
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process ISO
 biological_processGO:2001012 mesenchymal cell differentiation involved in renal system development IMP
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0031982 vesicle ISO
 molecular_functionGO:0005125 cytokine activity ISO
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity ISO
 molecular_functionGO:0008201 heparin binding IDA
 molecular_functionGO:0039706 co-receptor binding ISO
 molecular_functionGO:0042056 chemoattractant activity ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0070700 BMP receptor binding ISO


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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