MP:0000024 | lowered ear position | "outer ears which are situated below the normal location " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0000026 | abnormal inner ear morphology | "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776] |
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Allelic Composition: Smad1tm1Tako/Smad1tm1Tako Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2
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MP:0000030 | abnormal tympanic ring morphology | "malformed bony ring at the ear canal to which the tympanic membrane is attached" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0000036 | absent semicircular canals | "missing organ of balance; consists of three bony tubes within which the semicircular ducts are located" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL
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MP:0000037 | abnormal lateral semicircular canal | "anomaly of the lateral long bony tube of the labyrinth that is involved in the sense of balance " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA
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MP:0000042 | abnormal organ of Corti | "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0000060 | delayed bone ossification | "late onset of the formation of bone" [J:40203] |
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
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MP:0000065 | abnormal bone marrow cavities | "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295] |
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
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MP:0000077 | abnormal interparietal bone morphology | "malformed bone of the cranium; lies above and anterior to the occipital bone " [J:61509] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0000085 | large anterior fontanelle | "enlarged diamond-shaped membranous interval at the junction of the coronal, sagittal and metopic sutures of the cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0000087 | absent mandible | "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0000088 | short mandible | "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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MP:0000097 | short maxilla | "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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MP:0000102 | abnormal nasal bone morphology | "malformed elongated rectangular bone that forms part of the nasal bridge" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0000107 | abnormal frontal bone morphology | "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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MP:0000111 | cleft palate | "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Vldlrtm1Lex/Vldlrtm1Lex Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0000150 | abnormal rib morphology | "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311] |
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Allelic Composition: Gpc3Gt(Ex136)Byg/Gpc3+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Bmp4tm1Blh/Bmp4+,Gpc3tm1Snd/Y Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0000154 | rib fusion | "appearance of one or more ribs as a single structure" [J:62022, J:62023] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp7tm1Kry/Bmp7+ Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd
Allelic Composition: Bmp4tm1Blh/Bmp4+,Gpc3Gt(Ex136)Byg/Y Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Allelic Composition: Bmp4tm1Blh/Bmp4+,Gpc3tm1Snd/Y Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0000155 | asymmetric rib attachment | "loss of bilateral symmetry in rib attachments to the vertebral column or to the sternum" [J:19212] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp7tm1Kry/Bmp7+ Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd
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MP:0000157 | abnormal sternum morphology | "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp7tm1Kry/Bmp7+ Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd
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MP:0000164 | abnormal cartilage development | "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
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MP:0000168 | abnormal bone marrow development | "malformation or anomalous differentiation of the soft, pulpy tissue filling the medullary cavities of bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp2tm1Cjt/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
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MP:0000260 | abnormal angiogenesis | "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pde6brd1/Pde6brgsc1754 Genetic Background: involves: C3H * C57BL/6JJcl
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MP:0000267 | abnormal cardiac development | "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370] |
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Allelic Composition: Prrxl1tm1And/Prrxl1tm1And Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1
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MP:0000269 | abnormal looping morphogenesis | "atypical bending of the primitive heart tube during early development" [J:27443] |
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Allelic Composition: Ush1cdfcr/Ush1cdfcr Genetic Background: involves: BALB/cByJ
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MP:0000276 | right ventricle hypertrophy | "increased size of the right ventricle" [J:33629] |
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Allelic Composition: Pde6brd1/Pde6brgsc1754 Genetic Background: involves: C3H * C57BL/6JJcl
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MP:0000284 | double outlet right ventricle | "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826] |
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Allelic Composition: Thratm1Brnt/Thra+ Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0000297 | abnormal endocardial cushion morphology | "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Thratm1Brnt/Thra+ Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0000379 | reduced hair follicle number | "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108] |
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Allelic Composition: Bmp4tm2.1Blh/Bmp4+,Slc27a4pskn/Slc27a4pskn Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0000428 | abnormal craniofacial morphology | "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
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MP:0000443 | abnormal snout morphology | "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex Genetic Background: involves: 129S5/SvEvBrd
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MP:0000452 | abnormal mouth morphology | "anomalous structure or development of the oral cavity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL
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MP:0000455 | abnormal maxilla morphology | "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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MP:0000458 | abnormal mandible morphology | "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0000474 | abnormal foregut morphology | "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA
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MP:0000484 | abnormal pulmonary artery morphology | "structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0000516 | abnormal urinary system morphology | "structural or developmental anomaly of any of the organs involved in the production or excretion of urine " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apctm2Mmt/Apc+ Genetic Background: involves: 129X1/SvJ
Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+ Genetic Background: involves: 129 * 129S6/SvEvTac
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MP:0000519 | hydronephrosis | "dilation of the pelvis and calices of one or both kidneys" [J:56641] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
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MP:0000527 | abnormal kidney development | "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
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MP:0000534 | abnormal ureter morphology | "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Apctm2Mmt/Apc+ Genetic Background: involves: 129X1/SvJ
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MP:0000536 | hydroureter | "distention of the ureter with urine, due to blockage from any cause" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:Cml, J:13044] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
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MP:0000550 | abnormal forelimb morphology | "malformation of the entire anterior extremities" [MGI:tc] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc Genetic Background: either: B6.129P2-Apoetm1Unc/J or (involves: 129P2/OlaHsd * C57BL/6J * ICR)
Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
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MP:0000562 | polydactyly | "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp7tm1Kry/Bmp7+ Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd
Allelic Composition: Bmp2tm1Cjt/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
Allelic Composition: Bmp4tm1Blh/Bmp4+,Gli3Xt-J/Gli3+ Genetic Background: involves: 129S2/SvPas * C3H/HeJ * C57BL/6J * C57BL/6NHsd
Allelic Composition: Bmp4tm1Blh/Bmp4+,Gpc3Gt(Ex136)Byg/Y Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Allelic Composition: Bmp4tm1Blh/Bmp4+,Gpc3tm1Snd/Y Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0000564 | syndactyly | "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
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MP:0000572 | abnormal autopod morphology | "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
Allelic Composition: Bmp4tm1Blh/Bmp4+,Gli3Xt-J/Gli3+ Genetic Background: involves: 129S2/SvPas * C3H/HeJ * C57BL/6J * C57BL/6NHsd
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MP:0000585 | kinked tail | "a sharp bend or zig-zag in the tail" [J:61295] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0000592 | short tail | "reduced length of tail compared to control " [J:55583] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0000597 | delayed hepatic development | "late onset of the induction and/or differentiation of the liver" [J:18048] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA
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MP:0000783 | abnormal forebrain morphology | "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0000830 | abnormal diencephalon morphology | "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0000968 | abnormal sensory neuron innervation | "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0001145 | abnormal male reproductive anatomy | "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0001147 | small testis | "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc Genetic Background: either: B6.129P2-Apoetm1Unc/J or (involves: 129P2/OlaHsd * C57BL/6J * ICR)
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MP:0001154 | seminiferous tubule degeneration | "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc Genetic Background: either: B6.129P2-Apoetm1Unc/J or (involves: 129P2/OlaHsd * C57BL/6J * ICR)
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MP:0001163 | abnormal coagulating gland | "malformed or malfunctioning anterior lobe of the prostate" [J:64981] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0001175 | abnormal lung morphology | "malformed organ of respiration" [J:35802] |
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1a+,Tg(Sftpc-cre)1Blh/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Irf7m1Btlr/Irf7+ Genetic Background: C57BL/6J-Irf7m1Btlr
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MP:0001286 | abnormal eye development | "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840] |
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Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex Genetic Background: involves: 129S5/SvEvBrd
Allelic Composition: Bmp4tm3Blh/Bmp4tm3Blh Genetic Background: involves: 129S6/SvEvTac
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MP:0001288 | abnormal lens induction | "malformation of or failure to form the transparent, biconvex structure of the eye which is situated behind the iris and in front of the vitreous humor" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0001289 | persistence of hyaloid capillary system | "failure of the degeneration of the transient vascular system of the eye during development" [J:49840] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: involves: 129S2/SvPas * BALB/cJ
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MP:0001293 | anophthalmia | "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: B6.129S6-Bmp4tm2Blh
Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
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MP:0001297 | microphthalmia | "reduced average size of the eyes" [J:18048] |
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Allelic Composition: Plgtm1Jld/Plgtm1Jld Genetic Background: involves: 129P2/OlaHsd * Black Swiss * C57BL/6J
Allelic Composition: Bmp4tm2Blh/Bmp4+,Bmpertm1Ysas/Bmper+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: B6.129S6-Bmp4tm2Blh
Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
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MP:0001299 | abnormal eye distance/ position | "abnormal placement of the eyes in relation to each other or in relation to other craniofacial structures" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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MP:0001304 | cataracts | "complete or partial opacity of the lens" [J:65031] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: involves: 129S2/SvPas * CAST/Ei
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MP:0001312 | abnormal cornea morphology | "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0001314 | corneal opacity | "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0001319 | irregularly shaped pupil | "shape defects in the aperture of the iris through which light rays enter the eye, usually circular " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0001322 | abnormal iris morphology | "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
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MP:0001325 | abnormal retina morphology | "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0001330 | abnormal optic nerve morphology | "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0001333 | absent optic nerve | "absence of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0001394 | circling | "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: involves: 129S2/SvPas * ICR
Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA
Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0001676 | abnormal apical ectodermal ridge | "malformation of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc] |
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
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MP:0001680 | abnormal mesoderm development | "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ush1cdfcr/Ush1cdfcr Genetic Background: involves: BALB/cByJ
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MP:0001693 | failure of primitive streak formation | "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: B6.129S2-Bmp4tm1Blh/J
Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: 129S2/SvPas-Bmp4tm1Blh
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MP:0001718 | abnormal yolk sac | "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623] |
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Allelic Composition: Adatm1Vlr/Adatm1Vlr Genetic Background: either: 129P2/OlaHsd-Adatm1Vlr or (involves: (129P2/OlaHsd * FVB/N)
Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: B6.129S2-Bmp4tm1Blh/J
Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: 129S2/SvPas-Bmp4tm1Blh
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MP:0001719 | absent vitelline blood vessels | "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623] |
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Allelic Composition: Ihhtm1Amc/Ihhtm1Amc Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0001721 | absent blood islands | "missing pools of blood in the yolk sac" [J:12623] |
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Allelic Composition: Adatm1Vlr/Adatm1Vlr Genetic Background: either: 129P2/OlaHsd-Adatm1Vlr or (involves: (129P2/OlaHsd * FVB/N)
Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: B6.129S2-Bmp4tm1Blh/J
Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: 129S2/SvPas-Bmp4tm1Blh
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MP:0001726 | abnormal allantois | "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622] |
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Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
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MP:0001787 | pericardial edema | "accumulation of watery fluid in the pericardial sac of the heart" [J:52597] |
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Allelic Composition: Adartm1Olds/Adartm1Olds Genetic Background: involves: 129S/SvEv * C57BL/6J
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MP:0001923 | reduced female fertility | "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0001935 | reduced litter size | "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0002080 | prenatal lethality | "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hand2tm1Cse/Hand2tm1Dsr Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
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MP:0002081 | perinatal lethality | "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Thratm1Brnt/Thra+ Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0002082 | postnatal lethality | "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: involves: 129S2/SvPas * ICR
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MP:0002092 | abnormal eye morphology | "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: involves: 129S2/SvPas * ICR
Allelic Composition: Bmp4tm3.1Blh/Bmp4tm3.1Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss
Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * ICR
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MP:0002110 | abnormal digit morphology | "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: En1tm1.1(Wnt1)Wrst/En1+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
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MP:0002111 | abnormal tail morphology | "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0002113 | abnormal skeleton development | "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp2tm1Cjt/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
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MP:0002116 | abnormal craniofacial bone morphology | "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0002133 | abnormal respiratory system physiology | "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1a+,Tg(Sftpc-cre)1Blh/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR
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MP:0002161 | abnormal fertility/fecundity | "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp2tm1Cjt/Bmp2+,Bmp7tm1Rob/Bmp7+,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL
Allelic Composition: Bmp4tm2Blh/Bmp4+,Nogtm1Amc/Nog+ Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac
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MP:0002187 | abnormal fibula morphology | "malformation of the lateral and smaller bone of the lower limb" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+ Genetic Background: involves: 129 * 129S6/SvEvTac
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MP:0002191 | abnormal artery morphology | "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pde6brd1/Pde6brgsc1754 Genetic Background: involves: C3H * C57BL/6JJcl
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MP:0002192 | hydrops fetalis | "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0002216 | abnormal seminiferous tubule morphology | "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0002233 | abnormal nose morphology | "any structural anomaly of the organ that is specialized for smell and is part of the respiratory system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0002428 | abnormal semicircular canal | "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL
Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Tg(Pax2-cre)1Dje/0 Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * C57BL/6 * SJL
Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * C57BL/6 * SJL
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MP:0002546 | mydriasis | "dilation of one or both pupils" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cftrtm1Hgu/Cftrtm1Hgu Genetic Background: CF/3Ztm
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MP:0002633 | persistent truncus arteriosis | "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0002672 | abnormal branchial arch artery morphology | "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0002697 | abnormal eye size | "anomalous bulk of the organ of vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0002699 | abnormal vitreous body | "anomalies of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0002700 | opacity of vitreous body | "milky or cloudy eyeball that is impervious to light" [J:30249] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0002746 | abnormal semilunar valve morphology | "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0002759 | abnormal caudal vertebrae morphology | "malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0002796 | impaired skin barrier function | "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641] |
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Allelic Composition: Bmp4tm2.1Blh/Bmp4+,Slc27a4pskn/Slc27a4pskn Genetic Background: involves: 129S6/SvEvTac * FVB/N
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MP:0002836 | abnormal chorion | "malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
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MP:0002875 | decreased erythrocyte count | "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0002989 | small kidney | "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
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MP:0003052 | omphalocele | "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
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MP:0003068 | enlarged kidney | "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: B6.129S6-Bmp4tm2Blh
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MP:0003087 | absent allantois | "missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA
Allelic Composition: Bmp4tm2Blh/Bmp4tm2Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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MP:0003099 | retinal detachment | "detachment of the retina from the underlying inner wall of the eye, often from tension of the vitreous; may occur with aging or as a result of trauma" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:83544] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0003126 | abnormal vulva morphology | "anomaly in the structure of the external genitalia of the female" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+ Genetic Background: involves: 129 * 129S6/SvEvTac
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MP:0003138 | absent tympanic ring | "missing the bony ring at the ear canal to which the tympanic membrane is attached" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:46972] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0003161 | absent lateral semicircular canal | |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0003162 | reduced size of lateral semicircular canal | |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0003169 | abnormal scala media morphology | "any malformation or absence of the division of the spiral canal of the cochlea that contains the organ of Corti (the neuroepithelial receptor organ for hearing)" [J:23837, J:46972, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL
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MP:0003189 | fused joints | |
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
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MP:0003345 | decreased number of ribs | "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc Genetic Background: either: B6.129P2-Apoetm1Unc/J or (involves: 129P2/OlaHsd * C57BL/6J * ICR)
Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: B6.129S6-Bmp4tm2Blh
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MP:0003419 | delayed endochondral bone ossification | "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631] |
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
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MP:0003445 | sirenomelia | "fusion of the posterior limbs often with partial or complete fusion of the autopods" [J:67375] |
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Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+ Genetic Background: involves: 129 * 129S6/SvEvTac
Allelic Composition: Bmp4tm4Blh/Bmp4+,Bmp7tm1.1Dgra/Bmp7tm1.1Dgra,Hoxa3tm1(cre)Moon/Hoxa3+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac
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MP:0003446 | renal hypoplasia | "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+ Genetic Background: involves: 129 * 129S6/SvEvTac
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MP:0003584 | bifid ureter | "cleft of the ureter into two parts or branches" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
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MP:0003586 | ureter dilation | "abnormal distention of the ureter due to accumulation of fluid" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
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MP:0003604 | single kidney | |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0003672 | abnormal ureter development | "anomalous differentiation of the tube that conducts the urine from the renal pelvis to the bladder" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96485] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
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MP:0003675 | kidney cysts | "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
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MP:0003728 | abnormal photoreceptor layer | "malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0003827 | abnormal Wolffian duct morphology | "malformation of the transient embryonic tubes that empty into the cloca and degenerate in the male " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
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MP:0003854 | abnormal forelimb stylopod morphology | |
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
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MP:0003855 | abnormal forelimb zeugopod morphology | |
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
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MP:0003856 | abnormal hindlimb stylopod morphology | |
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
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MP:0003857 | abnormal hindlimb zeugopod morphology | |
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
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MP:0003920 | abnormal right ventricle morphology | "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB
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MP:0003938 | abnormal ear development | "developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: involves: 129S2/SvPas * ICR
Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA
Allelic Composition: Bmp4tm2Blh/Bmp4tm2Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: Bmp4tm5.1Bhr/Bmp4tm5.1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster
Allelic Composition: Bmp4tm5.1Bhr/Bmp4tm2.1Blh Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster
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MP:0004003 | abnormal vascular endothelial cell physiology | "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Pde6brd1/Pde6brgsc1754 Genetic Background: involves: C3H * C57BL/6JJcl
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MP:0004017 | duplex kidney | "a kidney that is split into two separate collecting systems; there may be a duplex ureter or a single ureter; may present unilaterally or bilaterally" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
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MP:0004066 | abnormal Henson s node morphology | "malformation of cells in the small pit at the anterior end of the primitive streak that are important in determining left-right asymmetry" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ush1cdfcr/Ush1cdfcr Genetic Background: involves: BALB/cByJ
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MP:0004157 | interrupted aortic arch | "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0004214 | abnormal long bone diaphysis morphology | "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
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MP:0004221 | abnormal iridocorneal angle | "any structural abnormality of the acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: involves: 129S2/SvPas * C3Hf/HeA * C57BL/LiA
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MP:0004223 | hypoplastic trabecular meshwork | "reduced size of the pore-like structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates" [MESH:A09.371.060.932, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0004224 | absent trabecular meshwork | "absence of the pore-like structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates" [MESH:A09.371.060.932, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0004226 | absent Schlemm s canal | "absence of the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0004277 | abnormal lateral ganglionic eminence morphology | "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0004282 | retrognathia | "abnormal posterior positioning of one or both jaws, particularly the mandible, relative to the facial skeleton and soft tissues" [J:41682, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex Genetic Background: involves: 129S5/SvEvBrd
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MP:0004376 | absent frontal bone | "absence of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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MP:0004377 | small frontal bone | "reduced size of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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MP:0004380 | short frontal bone | "reduced length of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0004384 | small interparietal bone | "reduced size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0004423 | abnormal squamosal bone morphology | "any structural anomaly of the thin, platelike part of the temporal bone" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0004458 | absent alisphenoid bone | "absence of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0004459 | small alisphenoid bone | "reduced size of either of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0004467 | absent zygomatic bone | "absence of the quadrilateral bone that forms the prominence of the cheek" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0004468 | small zygomatic bone | "reduced size of the quadrilateral bone that forms the prominence of the cheek" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0004470 | small nasal bone | "reduced size of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0004471 | short nasal bone | "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0004473 | absent nasal bone | "absence of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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MP:0004517 | decreased vestibular hair cell stereocilia number | "decreased number of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on vestibular hair cells in a staircase-like pattern" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0004539 | absent maxilla | "missing the upper bony framework of the mouth where the superior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0004559 | small allantois | "reduced size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
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MP:0004574 | broad limb buds | "increased anterior-posterior width of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings] |
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
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MP:0004595 | abnormal mandibular condyloid process morphology | "any structural anomaly of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0004596 | abnormal mandibular angle morphology | "any structural anomaly of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0004599 | abnormal vertebral arch morphology | "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Nogtm1Amc/Nogtm1Amc Genetic Background: involves: C57BL/6
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MP:0004601 | abnormal vertebral spinous process | "any structural anomaly of the dorsal projection of the vertebral arch that projects backward and downward from the junction of the laminae, and serves for the attachment of muscles and ligaments" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: B6.129S6-Bmp4tm2Blh
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MP:0004620 | cervical vertebral fusion | "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: B6.129S6-Bmp4tm2Blh
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MP:0004623 | thoracic vertebral fusion | "the union of one or more thoracic vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: B6.129S6-Bmp4tm2Blh
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MP:0004624 | abnormal thoracic cage | "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp7tm1Kry/Bmp7+ Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd
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MP:0004670 | small vertebral body | "decreased size of the main cylindrical portion of the vertebra ventral to the vertebral canal" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+,Bmpertm1Ysas/Bmpertm1Ysas Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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MP:0004672 | short ribs | "reduced length of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Apoetm1Unc/Apoetm1Unc Genetic Background: either: B6.129P2-Apoetm1Unc/J or (involves: 129P2/OlaHsd * C57BL/6J * ICR)
Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: B6.129S6-Bmp4tm2Blh
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MP:0004678 | split xiphoid process | "the appearance of an abnormal division of the posterior tip of the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp7tm1Kry/Bmp7+ Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd
Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
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MP:0004726 | abnormal nasal capsule morphology | "any structural abnormality in the cartilage around the developing nasal cavity of the embryo" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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MP:0004872 | absent nasal septum | "absence of the structure that separates the two nasal cavities" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0004899 | absent squamosal bone | "absence of the thin, plate-like part of the temporal bone" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0004911 | absent mandibular condyloid process | "absence of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0004912 | absent mandibular coronoid process | "absence of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0004913 | absent mandibular angle | "absence of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0004970 | kidney atrophy | "wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0005157 | holoprosencephaly | "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0005176 | eyelids fail to open | "eyes remain shut throughout life" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: involves: 129S2/SvPas * ICR
Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss
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MP:0005193 | abnormal anterior eye segment morphology | "anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: involves: 129S2/SvPas * C3Hf/HeA * C57BL/LiA
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MP:0005195 | abnormal posterior eye segment morphology | "anomalous structure of any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0005204 | abnormal canal of Schlemm morphology | "structural anomaly in the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0005221 | abnormal rostral-caudal axis patterning | "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Adatm1Vlr/Adatm1Vlr Genetic Background: either: 129P2/OlaHsd-Adatm1Vlr or (involves: (129P2/OlaHsd * FVB/N)
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MP:0005225 | abnormal vertebrae development | "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Nogtm1Amc/Nogtm1Amc Genetic Background: involves: C57BL/6
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MP:0005226 | abnormal vertebral arch development | "anomalous formation of the posterior projection from the body of a vertebra that encloses the vertebral foramen " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+,Bmpertm1Ysas/Bmpertm1Ysas Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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MP:0005227 | abnormal vertebral body development | "anomalous formation of the main portion of the vertebra anterior to the vertebral canal, and distinct from the vertebral arch" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+,Bmpertm1Ysas/Bmpertm1Ysas Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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MP:0005258 | ocular hypertension | "abnormal elevation of the intraocular pressure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0005312 | pericardial effusion | "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0005325 | abnormal glomerulus | "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0005543 | corneal thinning | "decreased thickness of the cornea, the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0005551 | abnormal eye electrophysiology | "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0005559 | increased circulating glucose level | "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0005592 | abnormal vascular smooth muscle morphology | "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Pde6brd1/Pde6brgsc1754 Genetic Background: involves: C3H * C57BL/6JJcl
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MP:0006011 | abnormal endolymphatic duct morphology | "any structural alteration in the small membranous canal, connecting with both saccule and utricle of the membranous labyrinth, passing through the aqueduct of vestibule, and terminating in the endolymphatic sac." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL
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MP:0006020 | reduced size of tympanic ring | "smaller than average tympanic ring" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0006089 | abnormal saccule morphology | "malformation in the smaller of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL
Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Tg(Pax2-cre)1Dje/0 Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * C57BL/6 * SJL
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MP:0006090 | abnormal utricle morphology | "malformation in the larger of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL
Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Tg(Pax2-cre)1Dje/0 Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * C57BL/6 * SJL
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MP:0006126 | abnormal outflow tract development | "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0 Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0 Genetic Background: involves: 129S4/SvJaeSor
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MP:0006226 | iris hypoplasia | "less than the normal number of cells in the iris" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0006241 | abnormal placement of pupils | "abnormal location of the pupil so that it is not in the center of the iris" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0006250 | abnormal line of Schwalbe | "malformation of the thickened peripheral margin of the vitreous membrane of the cornea" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0006279 | abnormal limb development | "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+ Genetic Background: involves: 129 * 129S6/SvEvTac
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MP:0006323 | abnormal extraembryonic mesoderm development | "malformation of the mesoderm of the extraembryonic tissue that is involved in forming the amnion, chorion,yolk sac, and body stalk" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: B6.129S2-Bmp4tm1Blh/J
Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: 129S2/SvPas-Bmp4tm1Blh
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MP:0006325 | impaired hearing | "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0006377 | abnormal vestibulocollic reflex | "any anomaly in the neural reflex which results from activation of afferents from the vestibular organs and uses neck movements to stabilize the head position in space" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0008271 | abnormal bone ossification | "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503] |
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
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MP:0008277 | abnormal sternum ossification | "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Gpc3Gt(Ex136)Byg/Y Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Allelic Composition: Bmp4tm1Blh/Bmp4+,Gpc3tm1Snd/Y Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0008392 | decreased primordial germ cell number | "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA
Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm1.1Jlch Genetic Background: B6.129-Bmp4tm1.1Jlch
Allelic Composition: Bmp4tm1.1Jlch/Bmp4+ Genetic Background: B6.129-Bmp4tm1.1Jlch
Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac
Allelic Composition: Bmp4tm1Blh/Bmp4+,Tg(Prdm14-Venus)1Sait/0 Genetic Background: involves: 129S2/SvPas
Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp8btm1Blh/Bmp8b+ Genetic Background: involves: 129/Sv * 129S2/SvPas * Black Swiss
Allelic Composition: Bmp4tm1Blh/Bmp4+,Ctdnep1tm1Ryn/Ctdnep1tm1Ryn Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA
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MP:0008393 | absent primordial germ cells | "absence of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA
Allelic Composition: Bmp4tm2Blh/Bmp4tm2Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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MP:0008488 | abnormal semicircular canal ampulla morphology | "any structural anomaly of the spherical enlargement at the base of each semicircular canal where they connect with the utricle, containing the crista ampullaris which detects movement of the fluid within the canals" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL
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MP:0008507 | thin retinal ganglion layer | "reduced thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0008511 | thin retinal inner nuclear layer | "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0008528 | polycystic kidney | "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: B6.129S6-Bmp4tm2Blh
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MP:0009052 | anal stenosis | "abnormal narrowing or constriction of the anal orifice" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+ Genetic Background: involves: 129 * 129S6/SvEvTac
Allelic Composition: Bmp4tm4Blh/Bmp4+,Bmp7tm1.1Dgra/Bmp7tm1.1Dgra,Hoxa3tm1(cre)Moon/Hoxa3+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac
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MP:0009203 | external male genitalia hypoplasia | "underdevelopment or reduced size of the external masculine genital organs, usually due to a reduced number of cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+ Genetic Background: involves: 129 * 129S6/SvEvTac
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MP:0009252 | absent urinary bladder | "absence of the inflatable musculomembranous bag for holding urine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+ Genetic Background: involves: 129 * 129S6/SvEvTac
Allelic Composition: Bmp4tm4Blh/Bmp4+,Bmp7tm1.1Dgra/Bmp7tm1.1Dgra,Hoxa3tm1(cre)Moon/Hoxa3+ Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac
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MP:0009274 | buphthalmos | "abnormal enlargement of the eye that is usually congenital and attended by symptoms of glaucoma" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: involves: 129S2/SvPas * C3Hf/HeA * C57BL/LiA
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MP:0009576 | oral atresia | "congenital blockage, fusion, or absence of the normal opening of the oral cavity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0009743 | preaxial polydactyly | "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433] |
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Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm1.1Jlch Genetic Background: B6.129-Bmp4tm1.1Jlch
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MP:0009874 | abnormal interdigital cell death | "change in the expected number of cells undergoing programmed cell death (apoptosis) in the autopod during development, precluding the sculpting of normal digits" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL
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MP:0009905 | absent tongue | "absence of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0010098 | abnormal retinal blood vessel pattern | "anomaly in the systematic arrangement of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0010117 | abnormal lateral plate mesoderm | "anomaly of the portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Ush1cdfcr/Ush1cdfcr Genetic Background: involves: BALB/cByJ
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MP:0010224 | abnormal heart ventricle outflow tract morphology | "any structural anomaly of the superior portion of the ventricles of the heart through which blood flows into the arteries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Adartm1Olds/Adartm1Olds Genetic Background: involves: 129S/SvEv * C57BL/6J
Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/?,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(Mef2c-cre)2Blk/? Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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MP:0010252 | anterior subcapsular cataracts | "a lens opacity localized beneath the anterior lens capsule" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0010256 | anterior cortical cataracts | "a lens opacity, frequently punctate, affecting the anterior pole of the lens cortex in which spokes or wedges progressively extend from the outside of the lens towards the center" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0010403 | atrial septal defect | "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375] |
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Allelic Composition: Thratm1Brnt/Thra+ Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0010404 | ostium primum atrial septal defect | "interatrial communication (atrial septal defect) through the most anterior and inferior aspect of the atrial septum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * ICR
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MP:0010413 | complete atrioventricular septal defect | "a type of atrioventricular septal defect in which a single atrioventricular valve annulus, a common atrioventricular valve, and a defect of the inlet ventricular septum are observed; deficiency of the atrioventricular septum also results in the presence of a large primum atrial septal defect" [http://emedicine.medscape.com] |
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Allelic Composition: Thratm1Brnt/Thra+ Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0010414 | partial atrioventricular septal defect | "a type of atrioventricular septal defect in which the endocardial cushion defects present have an interatrial communication but lack an interventricular communication; the mitral and tricuspid annuli are separate but one or more additional features are present, including primum atrial septal defect (ASD), inlet ventricular septal defect (VSD), cleft of the anterior mitral valve leaflet, and wide anteroseptal tricuspid valve commissure or cleft septal tricuspid leaflet" [http://emedicine.medscape.com] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * ICR
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MP:0010418 | perimembraneous ventricular septal defect | "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: B6.129S6-Bmp4tm2Blh
Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
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MP:0010426 | abnormal heart and great artery attachment | "any anomaly in the in the position or pattern of the connection site of the heart to any of the great arteries, including the pulmonary artery and aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0 Genetic Background: involves: 129S4/SvJaeSor
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MP:0010454 | abnormal truncus arteriosis septation | "anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0 Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0 Genetic Background: involves: 129S4/SvJaeSor
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MP:0010455 | aortopulmonary window | "a defect between the great vessels that results from failure of the conotruncal ridges to fuse resulting in an abnormal communication between the aorta and the pulmonary arteries" [http://emedicine.medscape.com] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0010464 | abnormal aortic arch and aortic arch branch attachment | "any anomaly of the connection site of the aortic branches to the aortic arch, including the attachment sites for the left common carotid artery, the left subclavian artery, and the brachiocephalic trunk which further splits to form the right subclavian artery and the right common carotid artery" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0010585 | abnormal conotruncal ridge morphology | "any structural anomaly of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0010587 | conotruncal ridge hypoplasia | "underdevelopment or reduced size of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
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MP:0010607 | common atrioventricular valve | "the presence of a single atrioventricular valve instead of both a mitral and tricuspid valve, most commonly due to incomplete or failure of fetal atrioventricular canal septation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Thratm1Brnt/Thra+ Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0010656 | thick myocardium | "increased thickness of the heart muscle layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/?,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(Mef2c-cre)2Blk/? Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
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MP:0010755 | abnormal heart right ventricle pressure | "any anomaly in the pressure within the right cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pde6brd1/Pde6brgsc1754 Genetic Background: involves: C3H * C57BL/6JJcl
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MP:0010980 | ectopic ureteric bud | "ureteric bud(s) are not located in the normal or expected position" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
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MP:0010982 | abnormal ureteric bud elongation | "any anomaly in the process in which a ureteric bud grows along its axis" [GO:0060677] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
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MP:0010984 | abnormal metanephric mesenchyme morphology | "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing metanephros; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:19828308] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
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MP:0010985 | abnormal kidney mesenchyme morphology | "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing kidney" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
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MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * ICR
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MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: B6.129S6-Bmp4tm2Blh
Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
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MP:0011089 | complete perinatal lethality | "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss
Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh,Tg(Tnnt2-cre)5Blh/0 Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR
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MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA
Allelic Composition: Bmp4tm5.1Bhr/Bmp4tm5.1Bhr Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster
Allelic Composition: Bmp4tm5.1Bhr/Bmp4tm2.1Blh Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster
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MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0011096 | complete embryonic lethality before somite formation | "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: B6.129S2-Bmp4tm1Blh/J
Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: 129S2/SvPas-Bmp4tm1Blh
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MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: involves: 129S2/SvPas * ICR
Allelic Composition: Bmp4tm3Blh/Bmp4tm3Blh,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Allelic Composition: Bmp4tm2Blh/Bmp4tm2Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss
Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0 Genetic Background: involves: 129S4/SvJaeSor
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MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Bmp4tm3Blh/Bmp4tm3Blh Genetic Background: involves: 129S6/SvEvTac
Allelic Composition: Bmp4tm3Blh/Bmp4+,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
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MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129S4/SvJaeSor
Allelic Composition: Bmp4tm3Blh/Bmp4tm3Blh Genetic Background: involves: 129S6/SvEvTac
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MP:0011109 | partial lethality throughout fetal growth and development | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
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MP:0011199 | abnormal amniotic cavity morphology | "any structural anomaly of the closed space between the embryo and the amnion, containing the amniotic fluid; it is formed by the fusion of the parts of the anterior and posterior amniotic folds" [ISBN:0-12-402035-6] |
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Allelic Composition: Ush1cdfcr/Ush1cdfcr Genetic Background: involves: BALB/cByJ
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MP:0011260 | abnormal head mesenchyme morphology | "any structural anomaly of the primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells" [ISBN:0-683-40008-8] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0011264 | abnormal cardiac mesenchyme morphology | "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures" [ISBN:0-683-40008-8, MGI:csmith] |
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0011305 | dilated kidney calyx | "an expansion in the lumen volume or area of any of the branches of the renal pelvis that surround each renal papilla and collect urine" [MGI:anna] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
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MP:0011334 | abnormal nephrogenic zone morphology | "any structural anomaly in the region found at the periphery of the developing metanephros within which the metanephric mesenchyme aggregates around the tips of the ureteric tree to form the nephrons; in rodents including mice, this region normally disappears within the first postnatal week when nephrogenesis ceases and only mature nephrons are present; in humans, it is lost by 36 weeks of gestation" [PMID:17452023] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
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MP:0011386 | increased metanephric mesenchyme apoptosis | "increase in the number of cells of the metanephric mesenchyme (MM) undergoing programmed cell death; usually due to failure of MM cells to interact with the ureteric bud (UB) tips after UB invasion" [MGI:anna] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
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MP:0011426 | abnormal ureter smooth muscle morphology | "any structural anomaly of the smooth muscle tissue surrounding the epithelium of the ureter" [MGI:anna] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
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MP:0011481 | anterior iris synechia | "adhesion of the iris to the cornea" [MGI:anna] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0011486 | ectopic ureter | "an abnormally placed opening of the ureter, either into the urinary bladder or at another site in the lower urinary or genital tract" [MGI:anna] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
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MP:0011488 | abnormal ureterovesical junction morphology | "any structural anomaly of the valve-like structure found at the site of entry of the ureter into the urinary bladder, normally displays an oblique angulation through the detrusor to avoid reflux of urine up the ureters and the kidney" [MGI:csmith] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
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MP:0011711 | decreased osteoblast differentiation | |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0011759 | absent Rathke s pouch | "absence of the diverticulum arsing from the embryonic buccal cavity from which the anterior lobe of the pituitary gland is developed" [MGI:anna] |
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0011783 | abnormal ureteral orifice morphology | "any structural anomaly of the slit-like opening of either ureter into the bladder; normally, the two ureteral orifices are placed at the posterolateral angles of the urinary bladder trigone while the internal urethral orifice is placed at its anteroinferior angle (apex); wide gaping usually indicates vesicoureteral reflux" [MGI:anna] |
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Allelic Composition: Bmp4tm2Blh/Bmp4+ Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J
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MP:0011851 | abnormal embryonic cloaca development | "failure or anomaly in the formation of a pouch-like dilation of the caudal end of the hindgut by the process of folding of the caudal region of the embryonic disk; during the tail-fold process, the posteriorly placed allantois, or allantoic diverticulum of the yolk sac, becomes an anterior extension of the cloaca; soon after the cloaca forms, it receives posterolaterally the caudal ends of the paired mesonephric ducts and hence becomes a junctional cistern for the allantois, the hindgut, and the ducts; a cloacal membrane, composed of ectoderm and endoderm, is the caudal limit of the primitive gut and temporarily separates the cloacal cavity from the extraembryonic confines of the amniotic cavity; subsequent growth of the urorectal septum eventually subdivides the once single cloaca chamber into the primitive urogenital sinus (ventrally) and the anorectal canal of the hindgut (dorsally)" [MGI:anna] |
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Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+ Genetic Background: involves: 129 * 129S6/SvEvTac
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MP:0011967 | increased or absent threshold for auditory brainstem response | "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+ Genetic Background: B6.129S2-Bmp4tm1Blh/J
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MP:0012235 | abnormal liver bud morphology | "any structural anomaly of the liver primordium formed as hepatoblasts delaminate from the anterior portion of the hepatic diverticulum and invade the adjacent septum transversum mesenchyme" [MGI:anna] |
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Allelic Composition: Bmp4tm2Blh/Bmp4tm2Blh Genetic Background: involves: 129S6/SvEvTac * Black Swiss
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MP:0012740 | abnormal posterior primitive streak morphology | "any structural anomaly of the posterior region of the vertebrate primitive streak which gives rise to the extraembryonic mesoderm" [MGI:anna] |
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Allelic Composition: Ush1cdfcr/Ush1cdfcr Genetic Background: involves: BALB/cByJ
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MP:0013167 | abnormal hindlimb bud morphology | "any structural anomaly of the limb bud that develops into a hindlimb (usually the leg or back limb in mammalian species)" [MGI:anna] |
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Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+ Genetic Background: involves: 129 * 129S6/SvEvTac
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MP:0013283 | failure of ventral body wall closure | "failure of the lateral body wall folds (a combination of mesoderm and ectoderm arising on each side of the embryo) to progress ventrally and meet in the midline and/or fuse to close the ventral body wall; normally, this closure is aided by growth of the head and tail folds that cause the embryo to curve into the fetal position and is complete except in the region of the connecting stalk (future umbilical cord); if closure fails, ventral body wall defects occur in the thorax, abdomen, and pelvis and involve the heart (ectopia cordis), abdominal viscera (gastroschisis), and/or urogenital organs (bladder or cloacal exstrophy), depending upon the location and size of the abnormality" [http://www.nbdpn.org/current/2008pdf/AMPresentations/EmbryologySadler.pdf, https://www.inkling.com/read/langmans-medical-embryology-thomas-sadler-12th/chapter-7/ch07-clinical-correlates-01, MGI:anna] |
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Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
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MP:0013790 | single external naris | "presence of only one anterior opening to the nasal cavity as opposed to the normal two; usually associated with midline facial defects arising from cleavage anomalies" [MGI:Anna] |
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL
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MP:0020516 | abnormal visceral yolk sac mesenchyme morphology | "any structural anomaly of the portion of the visceral yolk sac that is derived from mesoderm and consists of mesenchyme" [UBERON:0003316] |
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0030066 | short face | "an abnormally decreased height (length) of the face" [MGI:anna] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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MP:0030121 | small temporal bone squamous part | "reduced size of the anterosuperior portion of the temporal bone that is thin, scale-like, and translucent and forms part of the lateral wall of the cranial vault" [MGI:anna] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
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MP:0030245 | round head | "overall shape of the head is more circular than usual as viewed from the front" [MGI:anna] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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MP:0030283 | small mandibular coronoid process | "reduced size of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion)" [MGI:anna] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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MP:0030313 | abnormal face development | "any anomaly in the process in which the anatomical structures of the face are generated and organized" [GO:0060325] |
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Allelic Composition: Bmp4tm3Blh/Bmp4tm3Blh,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
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MP:0030372 | enlarged Meckel s cartilage | "increased size of the cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible and gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [MGI:anna] |
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0 Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J
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