ENSMUSG00000021835


Mus musculus

Features
Gene ID: ENSMUSG00000021835
  
Biological name :Bmp4
  
Synonyms : Bmp4 / Bone morphotic protein 4 / P21275
  
Possible biological names infered from orthology : bone morphogenetic protein 4 / P12644
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C1
Gene start: 46383520
Gene end: 46390669
  
Corresponding Affymetrix probe sets: 10419261 (MoGene1.0st)   1422912_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000073720
Ensembl peptide - ENSMUSP00000098242
NCBI entrez gene - 12159     See in Manteia.
MGI - MGI:88180
RefSeq - XM_011244935
RefSeq - NM_001316360
RefSeq - NM_007554
RefSeq - XM_006518467
RefSeq - XM_006518468
RefSeq - XM_011244934
RefSeq Peptide - NP_001303289
RefSeq Peptide - NP_031580
swissprot - P21275
swissprot - Q3ULR1
Ensembl - ENSMUSG00000021835
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmp4ENSDARG00000019995Danio rerio
 BMP4ENSGALG00000012429Gallus gallus
 BMP4ENSG00000125378Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bmp2 / P21274 / Bone morphotic protein 2 / P12643* / bone morphogenetic protein 2*ENSMUSG0000002735860
Bmp6 / P20722 / Bone morphotic protein 6 / P22004* / bone morphogenetic protein 6*ENSMUSG0000003900432
Bmp5 / P49003 / Bone morphotic protein 5 / P22003* / bone morphogenetic protein 5*ENSMUSG0000003217931
Bmp7 / P23359 / Bone morphotic protein 7 / P18075* / bone morphogenetic protein 7*ENSMUSG0000000899931
Bmp10 / Q9R229 / Bone morphotic protein 10 / O95393* / bone morphogenetic protein 10*ENSMUSG0000003004629
Gdf6 / P43028 / Growth/differentiation factor 6 / Q6KF10*ENSMUSG0000005127929
Bmp8a / P34821 / Bone morphotic protein 8A / BMP8B* / P34820* / Q7Z5Y6* / bone morphogenetic protein 8b* / bone morphogenetic protein 8a*ENSMUSG0000003272628
Gdf2 / Q9WV56 / Growth/differentiation factor 2 / Q9UK05*ENSMUSG0000007262528
Bmp8b / P55105 / Bone morphotic protein 8B / BMP8A* / P34820* / Q7Z5Y6* / bone morphogenetic protein 8b* / bone morphogenetic protein 8a*ENSMUSG0000000238427
Gdf5 / P43027 / Growth/differentiation factor 5 / P43026*ENSMUSG0000003825927
Gdf7 / P43029 / Growth/differentiation factor 7 / Q7Z4P5*ENSMUSG0000003766026


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000186 activation of MAPKK activity ISS
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001568 blood vessel development IDA
 biological_processGO:0001649 osteoblast differentiation ISO
 biological_processGO:0001656 metanephros development IMP
 biological_processGO:0001657 ureteric bud development ISO
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis ISS
 biological_processGO:0001707 mesoderm formation IDA
 biological_processGO:0001759 organ induction IMP
 biological_processGO:0001822 kidney development ISS
 biological_processGO:0001823 mesonephros development ISS
 biological_processGO:0001843 neural tube closure IDA
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0001936 regulation of endothelial cell proliferation TAS
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IDA
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0001958 endochondral ossification IMP
 biological_processGO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
 biological_processGO:0002062 chondrocyte differentiation IMP
 biological_processGO:0002244 hematopoietic progenitor cell differentiation ISS
 biological_processGO:0002320 lymphoid progenitor cell differentiation ISO
 biological_processGO:0003014 renal system process IMP
 biological_processGO:0003130 BMP signaling pathway involved in heart induction ISS
 biological_processGO:0003139 secondary heart field specification ISO
 biological_processGO:0003148 outflow tract septum morphogenesis IMP
 biological_processGO:0003149 membranous septum morphogenesis IMP
 biological_processGO:0003151 outflow tract morphogenesis IGI
 biological_processGO:0003180 aortic valve morphogenesis IMP
 biological_processGO:0003184 pulmonary valve morphogenesis IMP
 biological_processGO:0003197 endocardial cushion development IMP
 biological_processGO:0003323 type B pancreatic cell development ISS
 biological_processGO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis ISO
 biological_processGO:0007182 common-partner SMAD protein phosphorylation ISO
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007281 germ cell development IMP
 biological_processGO:0007492 endoderm development IDA
 biological_processGO:0007500 mesodermal cell fate determination IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0009791 post-embryonic development ISO
 biological_processGO:0009888 tissue development IGI
 biological_processGO:0009948 anterior/posterior axis specification IGI
 biological_processGO:0010159 specification of animal organ position IMP
 biological_processGO:0010453 regulation of cell fate commitment ISS
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration ISS
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010629 negative regulation of gene expression IDA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IGI
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation ISO
 biological_processGO:0010942 positive regulation of cell death ISO
 biological_processGO:0021537 telencephalon development ISO
 biological_processGO:0021904 dorsal/ventral neural tube patterning IDA
 biological_processGO:0021978 telencephalon regionalization IGI
 biological_processGO:0021983 pituitary gland development IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030218 erythrocyte differentiation IDA
 biological_processGO:0030224 monocyte differentiation ISO
 biological_processGO:0030225 macrophage differentiation ISO
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030326 embryonic limb morphogenesis IMP
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0030501 positive regulation of bone mineralization ISS
 biological_processGO:0030509 BMP signaling pathway ISS
 biological_processGO:0030513 positive regulation of BMP signaling pathway IDA
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0032092 positive regulation of protein binding ISO
 biological_processGO:0032331 negative regulation of chondrocyte differentiation IDA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process ISS
 biological_processGO:0033085 negative regulation of T cell differentiation in thymus ISO
 biological_processGO:0033088 negative regulation of immature T cell proliferation in thymus ISO
 biological_processGO:0034504 protein localization to nucleus ISS
 biological_processGO:0035116 embryonic hindlimb morphogenesis IGI
 biological_processGO:0035990 tendon cell differentiation IMP
 biological_processGO:0035993 deltoid tuberosity development IMP
 biological_processGO:0042306 regulation of protein import into nucleus ISO
 biological_processGO:0042326 negative regulation of phosphorylation ISO
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IGI
 biological_processGO:0042476 odontogenesis ISO
 biological_processGO:0042487 regulation of odontogenesis of dentin-containing tooth IGI
 biological_processGO:0042733 embryonic digit morphogenesis IGI
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0043401 steroid hormone mediated signaling pathway ISO
 biological_processGO:0043407 negative regulation of MAP kinase activity ISO
 biological_processGO:0045165 cell fate commitment IDA
 biological_processGO:0045595 regulation of cell differentiation IGI
 biological_processGO:0045597 positive regulation of cell differentiation IDA
 biological_processGO:0045603 positive regulation of endothelial cell differentiation IDA
 biological_processGO:0045606 positive regulation of epidermal cell differentiation ISO
 biological_processGO:0045662 negative regulation of myoblast differentiation ISO
 biological_processGO:0045666 positive regulation of neuron differentiation IDA
 biological_processGO:0045669 positive regulation of osteoblast differentiation ISS
 biological_processGO:0045778 positive regulation of ossification ISO
 biological_processGO:0045786 negative regulation of cell cycle ISS
 biological_processGO:0045839 negative regulation of mitotic nuclear division ISO
 biological_processGO:0045843 negative regulation of striated muscle tissue development ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048286 lung alveolus development ISO
 biological_processGO:0048333 mesodermal cell differentiation IDA
 biological_processGO:0048392 intermediate mesodermal cell differentiation ISO
 biological_processGO:0048593 camera-type eye morphogenesis IMP
 biological_processGO:0048598 embryonic morphogenesis IMP
 biological_processGO:0048646 anatomical structure formation involved in morphogenesis IGI
 biological_processGO:0048660 regulation of smooth muscle cell proliferation IDA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation ISO
 biological_processGO:0048663 neuron fate commitment IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0048704 embryonic skeletal system morphogenesis IMP
 biological_processGO:0048706 embryonic skeletal system development IMP
 biological_processGO:0048745 smooth muscle tissue development IMP
 biological_processGO:0048754 branching morphogenesis of an epithelial tube ISS
 biological_processGO:0050679 positive regulation of epithelial cell proliferation ISS
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IMP
 biological_processGO:0050918 positive chemotaxis ISS
 biological_processGO:0051145 smooth muscle cell differentiation IDA
 biological_processGO:0051150 regulation of smooth muscle cell differentiation IGI
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0055007 cardiac muscle cell differentiation IGI
 biological_processGO:0055020 positive regulation of cardiac muscle fiber development ISO
 biological_processGO:0060113 inner ear receptor cell differentiation IGI
 biological_processGO:0060197 cloacal septation IEP
 biological_processGO:0060235 lens induction in camera-type eye IMP
 biological_processGO:0060272 embryonic skeletal joint morphogenesis IMP
 biological_processGO:0060348 bone development IDA
 biological_processGO:0060363 cranial suture morphogenesis IDA
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction ISS
 biological_processGO:0060393 regulation of pathway-restricted SMAD protein phosphorylation ISO
 biological_processGO:0060395 SMAD protein signal transduction ISS
 biological_processGO:0060425 lung morphogenesis ISO
 biological_processGO:0060429 epithelium development IDA
 biological_processGO:0060433 bronchus development ISO
 biological_processGO:0060438 trachea development ISO
 biological_processGO:0060440 trachea formation IMP
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis ISO
 biological_processGO:0060442 branching involved in prostate gland morphogenesis IMP
 biological_processGO:0060449 bud elongation involved in lung branching IDA
 biological_processGO:0060502 epithelial cell proliferation involved in lung morphogenesis ISO
 biological_processGO:0060503 bud dilation involved in lung branching ISO
 biological_processGO:0060512 prostate gland morphogenesis IMP
 biological_processGO:0060548 negative regulation of cell death ISS
 biological_processGO:0060592 mammary gland formation IMP
 biological_processGO:0060684 epithelial-mesenchymal cell signaling IDA
 biological_processGO:0060686 negative regulation of prostatic bud formation IMP
 biological_processGO:0060687 regulation of branching involved in prostate gland morphogenesis IMP
 biological_processGO:0060688 regulation of morphogenesis of a branching structure IMP
 biological_processGO:0060976 coronary vasculature development IMP
 biological_processGO:0061035 regulation of cartilage development IDA
 biological_processGO:0061036 positive regulation of cartilage development ISO
 biological_processGO:0061047 positive regulation of branching involved in lung morphogenesis IMP
 biological_processGO:0061149 BMP signaling pathway involved in ureter morphogenesis IDA
 biological_processGO:0061151 BMP signaling pathway involved in renal system segmentation IMP
 biological_processGO:0061155 pulmonary artery endothelial tube morphogenesis ISO
 biological_processGO:0061312 BMP signaling pathway involved in heart development IMP
 biological_processGO:0061626 pharyngeal arch artery morphogenesis IMP
 biological_processGO:0070244 negative regulation of thymocyte apoptotic process ISS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0071363 cellular response to growth factor stimulus IDA
 biological_processGO:0071773 cellular response to BMP stimulus ISO
 biological_processGO:0071893 BMP signaling pathway involved in nephric duct formation ISO
 biological_processGO:0072001 renal system development IGI
 biological_processGO:0072015 glomerular visceral epithelial cell development IEP
 biological_processGO:0072097 negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway ISO
 biological_processGO:0072101 specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway ISO
 biological_processGO:0072104 glomerular capillary formation IMP
 biological_processGO:0072125 negative regulation of glomerular mesangial cell proliferation ISO
 biological_processGO:0072138 mesenchymal cell proliferation involved in ureteric bud development IEP
 biological_processGO:0072161 mesenchymal cell differentiation involved in kidney development IMP
 biological_processGO:0072192 ureter epithelial cell differentiation IMP
 biological_processGO:0072193 ureter smooth muscle cell differentiation IMP
 biological_processGO:0072198 mesenchymal cell proliferation involved in ureter development IEP
 biological_processGO:0072200 negative regulation of mesenchymal cell proliferation involved in ureter development ISO
 biological_processGO:0072205 metanephric collecting duct development IMP
 biological_processGO:0090184 positive regulation of kidney development ISO
 biological_processGO:0090191 negative regulation of branching involved in ureteric bud morphogenesis ISS
 biological_processGO:0090194 negative regulation of glomerulus development ISO
 biological_processGO:1901964 positive regulation of cell proliferation involved in outflow tract morphogenesis IMP
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IGI
 biological_processGO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA ISO
 biological_processGO:1905312 positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis IGI
 biological_processGO:2000005 negative regulation of metanephric S-shaped body morphogenesis ISO
 biological_processGO:2000007 negative regulation of metanephric comma-shaped body morphogenesis ISO
 biological_processGO:2000105 positive regulation of DNA-dependent DNA replication ISO
 biological_processGO:2000137 negative regulation of cell proliferation involved in heart morphogenesis ISO
 biological_processGO:2001012 mesenchymal cell differentiation involved in renal system development IMP
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity ISO
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding IDA
 molecular_functionGO:0039706 co-receptor binding ISO
 molecular_functionGO:0042056 chemoattractant activity ISS
 molecular_functionGO:0070700 BMP receptor binding ISS


Pathways (from Reactome)
Pathway description
Molecules associated with elastic fibres
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000024 lowered ear position "outer ears which are situated below the normal location " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

 MP:0000026 abnormal inner ear morphology "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Smad1tm1Tako/Smad1tm1Tako
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0000030 abnormal tympanic ring morphology "malformed bony ring at the ear canal to which the tympanic membrane is attached" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0000036 absent semicircular canals "missing organ of balance; consists of three bony tubes within which the semicircular ducts are located" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL

 MP:0000037 abnormal lateral semicircular canal "anomaly of the lateral long bony tube of the labyrinth that is involved in the sense of balance " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0000077 abnormal interparietal bone morphology "malformed bone of the cranium; lies above and anterior to the occipital bone " [J:61509]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0000085 large anterior fontanelle "enlarged diamond-shaped membranous interval at the junction of the coronal, sagittal and metopic sutures of the cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0000087 absent mandible "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0000102 abnormal nasal bone morphology "malformed elongated rectangular bone that forms part of the nasal bridge" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0000107 abnormal frontal bone morphology "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Vldlrtm1Lex/Vldlrtm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Gpc3Gt(Ex136)Byg/Gpc3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Bmp4tm1Blh/Bmp4+,Gpc3tm1Snd/Y
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp7tm1Kry/Bmp7+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

Allelic Composition: Bmp4tm1Blh/Bmp4+,Gpc3Gt(Ex136)Byg/Y
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Bmp4tm1Blh/Bmp4+,Gpc3tm1Snd/Y
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0000155 asymmetric rib attachment "loss of bilateral symmetry in rib attachments to the vertebral column or to the sternum" [J:19212]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp7tm1Kry/Bmp7+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp7tm1Kry/Bmp7+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0000168 abnormal bone marrow development "malformation or anomalous differentiation of the soft, pulpy tissue filling the medullary cavities of bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp2tm1Cjt/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pde6brd1/Pde6brgsc1754
Genetic Background: involves: C3H * C57BL/6JJcl

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
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Allelic Composition: Ush1cdfcr/Ush1cdfcr
Genetic Background: involves: BALB/cByJ

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Pde6brd1/Pde6brgsc1754
Genetic Background: involves: C3H * C57BL/6JJcl

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Thratm1Brnt/Thra+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000297 abnormal endocardial cushion morphology "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Thratm1Brnt/Thra+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Bmp4tm2.1Blh/Bmp4+,Slc27a4pskn/Slc27a4pskn
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0000452 abnormal mouth morphology "anomalous structure or development of the oral cavity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0000474 abnormal foregut morphology "malformed cephalic portion of the primitive digestive tube of the embryo" [J:35802]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0000484 abnormal pulmonary artery morphology "structrual anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, hdene:Howard Dene, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000516 abnormal urinary system morphology "structural or developmental anomaly of any of the organs involved in the production or excretion of urine " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apctm2Mmt/Apc+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129 * 129S6/SvEvTac

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0000534 abnormal ureter morphology "anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apctm2Mmt/Apc+
Genetic Background: involves: 129X1/SvJ

 MP:0000536 hydroureter "distention of the ureter with urine, due to blockage from any cause" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:Cml, J:13044]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: either: B6.129P2-Apoetm1Unc/J or (involves: 129P2/OlaHsd * C57BL/6J * ICR)

Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp7tm1Kry/Bmp7+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

Allelic Composition: Bmp2tm1Cjt/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Bmp4tm1Blh/Bmp4+,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S2/SvPas * C3H/HeJ * C57BL/6J * C57BL/6NHsd

Allelic Composition: Bmp4tm1Blh/Bmp4+,Gpc3Gt(Ex136)Byg/Y
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Bmp4tm1Blh/Bmp4+,Gpc3tm1Snd/Y
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Bmp4tm1Blh/Bmp4+,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S2/SvPas * C3H/HeJ * C57BL/6J * C57BL/6NHsd

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

 MP:0000597 delayed hepatic development "late onset of the induction and/or differentiation of the liver" [J:18048]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: either: B6.129P2-Apoetm1Unc/J or (involves: 129P2/OlaHsd * C57BL/6J * ICR)

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: either: B6.129P2-Apoetm1Unc/J or (involves: 129P2/OlaHsd * C57BL/6J * ICR)

 MP:0001163 abnormal coagulating gland "malformed or malfunctioning anterior lobe of the prostate" [J:64981]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1a+,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Irf7m1Btlr/Irf7+
Genetic Background: C57BL/6J-Irf7m1Btlr

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Bmp4tm3Blh/Bmp4tm3Blh
Genetic Background: involves: 129S6/SvEvTac

 MP:0001288 abnormal lens induction "malformation of or failure to form the transparent, biconvex structure of the eye which is situated behind the iris and in front of the vitreous humor" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * BALB/cJ

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: B6.129S6-Bmp4tm2Blh

Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * C57BL/6J

Allelic Composition: Bmp4tm2Blh/Bmp4+,Bmpertm1Ysas/Bmper+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: B6.129S6-Bmp4tm2Blh

Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0001299 abnormal eye distance/ position "abnormal placement of the eyes in relation to each other or in relation to other craniofacial structures" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * CAST/Ei

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0001319 irregularly shaped pupil "shape defects in the aperture of the iris through which light rays enter the eye, usually circular " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0001333 absent optic nerve "absence of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: involves: 129S2/SvPas * ICR

Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0001676 abnormal apical ectodermal ridge "malformation of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ush1cdfcr/Ush1cdfcr
Genetic Background: involves: BALB/cByJ

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: B6.129S2-Bmp4tm1Blh/J

Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: 129S2/SvPas-Bmp4tm1Blh

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Adatm1Vlr/Adatm1Vlr
Genetic Background: either: 129P2/OlaHsd-Adatm1Vlr or (involves: (129P2/OlaHsd * FVB/N)

Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: B6.129S2-Bmp4tm1Blh/J

Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: 129S2/SvPas-Bmp4tm1Blh

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: Ihhtm1Amc/Ihhtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001721 absent blood islands "missing pools of blood in the yolk sac" [J:12623]
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Allelic Composition: Adatm1Vlr/Adatm1Vlr
Genetic Background: either: 129P2/OlaHsd-Adatm1Vlr or (involves: (129P2/OlaHsd * FVB/N)

Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: B6.129S2-Bmp4tm1Blh/J

Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: 129S2/SvPas-Bmp4tm1Blh

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
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Allelic Composition: Adartm1Olds/Adartm1Olds
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hand2tm1Cse/Hand2tm1Dsr
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thratm1Brnt/Thra+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: involves: 129S2/SvPas * ICR

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: involves: 129S2/SvPas * ICR

Allelic Composition: Bmp4tm3.1Blh/Bmp4tm3.1Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss

Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * ICR

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: En1tm1.1(Wnt1)Wrst/En1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp2tm1Cjt/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmpr1atm2.1Bhr/Bmpr1a+,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 * ICR

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp2tm1Cjt/Bmp2+,Bmp7tm1Rob/Bmp7+,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Bmp4tm2Blh/Bmp4+,Nogtm1Amc/Nog+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

 MP:0002187 abnormal fibula morphology "malformation of the lateral and smaller bone of the lower limb" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129 * 129S6/SvEvTac

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pde6brd1/Pde6brgsc1754
Genetic Background: involves: C3H * C57BL/6JJcl

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0002233 abnormal nose morphology "any structural anomaly of the organ that is specialized for smell and is part of the respiratory system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

 MP:0002428 abnormal semicircular canal "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL

Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Tg(Pax2-cre)1Dje/0
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * C57BL/6 * SJL

Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * C57BL/6 * SJL

 MP:0002546 mydriasis "dilation of one or both pupils" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cftrtm1Hgu/Cftrtm1Hgu
Genetic Background: CF/3Ztm

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002672 abnormal branchial arch artery morphology "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002697 abnormal eye size "anomalous bulk of the organ of vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0002699 abnormal vitreous body "anomalies of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0002700 opacity of vitreous body "milky or cloudy eyeball that is impervious to light" [J:30249]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0002746 abnormal semilunar valve morphology "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002759 abnormal caudal vertebrae morphology "malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Bmp4tm2.1Blh/Bmp4+,Slc27a4pskn/Slc27a4pskn
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0002836 abnormal chorion "malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: B6.129S6-Bmp4tm2Blh

 MP:0003087 absent allantois "missing fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

Allelic Composition: Bmp4tm2Blh/Bmp4tm2Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0003099 retinal detachment "detachment of the retina from the underlying inner wall of the eye, often from tension of the vitreous; may occur with aging or as a result of trauma" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:83544]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0003126 abnormal vulva morphology "anomaly in the structure of the external genitalia of the female" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129 * 129S6/SvEvTac

 MP:0003138 absent tympanic ring "missing the bony ring at the ear canal to which the tympanic membrane is attached" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:46972]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0003161 absent lateral semicircular canal 
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003162 reduced size of lateral semicircular canal 
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003169 abnormal scala media morphology "any malformation or absence of the division of the spiral canal of the cochlea that contains the organ of Corti (the neuroepithelial receptor organ for hearing)" [J:23837, J:46972, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL

 MP:0003189 fused joints 
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: either: B6.129P2-Apoetm1Unc/J or (involves: 129P2/OlaHsd * C57BL/6J * ICR)

Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: B6.129S6-Bmp4tm2Blh

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0003445 sirenomelia "fusion of the posterior limbs often with partial or complete fusion of the autopods" [J:67375]
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Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129 * 129S6/SvEvTac

Allelic Composition: Bmp4tm4Blh/Bmp4+,Bmp7tm1.1Dgra/Bmp7tm1.1Dgra,Hoxa3tm1(cre)Moon/Hoxa3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129 * 129S6/SvEvTac

 MP:0003584 bifid ureter "cleft of the ureter into two parts or branches" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0003586 ureter dilation "abnormal distention of the ureter due to accumulation of fluid" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0003604 single kidney 
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0003672 abnormal ureter development "anomalous differentiation of the tube that conducts the urine from the renal pelvis to the bladder" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96485]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0003728 abnormal photoreceptor layer "malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0003827 abnormal Wolffian duct morphology "malformation of the transient embryonic tubes that empty into the cloca and degenerate in the male " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0003854 abnormal forelimb stylopod morphology 
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0003855 abnormal forelimb zeugopod morphology 
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0003856 abnormal hindlimb stylopod morphology 
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0003857 abnormal hindlimb zeugopod morphology 
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0003920 abnormal right ventricle morphology "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Tg(Slc2a4-cre)546Dac/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB

 MP:0003938 abnormal ear development "developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: involves: 129S2/SvPas * ICR

Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

Allelic Composition: Bmp4tm2Blh/Bmp4tm2Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Bmp4tm5.1Bhr/Bmp4tm5.1Bhr
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster

Allelic Composition: Bmp4tm5.1Bhr/Bmp4tm2.1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pde6brd1/Pde6brgsc1754
Genetic Background: involves: C3H * C57BL/6JJcl

 MP:0004017 duplex kidney "a kidney that is split into two separate collecting systems; there may be a duplex ureter or a single ureter; may present unilaterally or bilaterally" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0004066 abnormal Henson s node morphology "malformation of cells in the small pit at the anterior end of the primitive streak that are important in determining left-right asymmetry" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ush1cdfcr/Ush1cdfcr
Genetic Background: involves: BALB/cByJ

 MP:0004157 interrupted aortic arch "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004214 abnormal long bone diaphysis morphology "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0004221 abnormal iridocorneal angle "any structural abnormality of the acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * C3Hf/HeA * C57BL/LiA

 MP:0004223 hypoplastic trabecular meshwork "reduced size of the pore-like structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates" [MESH:A09.371.060.932, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0004224 absent trabecular meshwork "absence of the pore-like structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates" [MESH:A09.371.060.932, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0004226 absent Schlemm s canal "absence of the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0004277 abnormal lateral ganglionic eminence morphology "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

 MP:0004282 retrognathia "abnormal posterior positioning of one or both jaws, particularly the mandible, relative to the facial skeleton and soft tissues" [J:41682, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53bp1Gt(OST94324)Lex/Trp53bp1Gt(OST94324)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0004376 absent frontal bone "absence of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0004377 small frontal bone "reduced size of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0004380 short frontal bone "reduced length of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0004384 small interparietal bone "reduced size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004423 abnormal squamosal bone morphology "any structural anomaly of the thin, platelike part of the temporal bone" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004458 absent alisphenoid bone "absence of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004459 small alisphenoid bone "reduced size of either of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004467 absent zygomatic bone "absence of the quadrilateral bone that forms the prominence of the cheek" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004468 small zygomatic bone "reduced size of the quadrilateral bone that forms the prominence of the cheek" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004470 small nasal bone "reduced size of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0004473 absent nasal bone "absence of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0004517 decreased vestibular hair cell stereocilia number "decreased number of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on vestibular hair cells in a staircase-like pattern" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0004539 absent maxilla "missing the upper bony framework of the mouth where the superior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004559 small allantois "reduced size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0004574 broad limb buds "increased anterior-posterior width of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0004595 abnormal mandibular condyloid process morphology "any structural anomaly of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004596 abnormal mandibular angle morphology "any structural anomaly of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004599 abnormal vertebral arch morphology "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: C57BL/6

 MP:0004601 abnormal vertebral spinous process "any structural anomaly of the dorsal projection of the vertebral arch that projects backward and downward from the junction of the laminae, and serves for the attachment of muscles and ligaments" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: B6.129S6-Bmp4tm2Blh

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: B6.129S6-Bmp4tm2Blh

 MP:0004623 thoracic vertebral fusion "the union of one or more thoracic vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: B6.129S6-Bmp4tm2Blh

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp7tm1Kry/Bmp7+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

 MP:0004670 small vertebral body "decreased size of the main cylindrical portion of the vertebra ventral to the vertebral canal" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp4tm2Blh/Bmp4+,Bmpertm1Ysas/Bmpertm1Ysas
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0004672 short ribs "reduced length of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc
Genetic Background: either: B6.129P2-Apoetm1Unc/J or (involves: 129P2/OlaHsd * C57BL/6J * ICR)

Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: B6.129S6-Bmp4tm2Blh

 MP:0004678 split xiphoid process "the appearance of an abnormal division of the posterior tip of the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp7tm1Kry/Bmp7+
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0004726 abnormal nasal capsule morphology "any structural abnormality in the cartilage around the developing nasal cavity of the embryo" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0004872 absent nasal septum "absence of the structure that separates the two nasal cavities" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

 MP:0004899 absent squamosal bone "absence of the thin, plate-like part of the temporal bone" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004911 absent mandibular condyloid process "absence of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004912 absent mandibular coronoid process "absence of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004913 absent mandibular angle "absence of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0004970 kidney atrophy "wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

 MP:0005176 eyelids fail to open "eyes remain shut throughout life" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: involves: 129S2/SvPas * ICR

Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss

 MP:0005193 abnormal anterior eye segment morphology "anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * C3Hf/HeA * C57BL/LiA

 MP:0005195 abnormal posterior eye segment morphology "anomalous structure of any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0005204 abnormal canal of Schlemm morphology "structural anomaly in the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adatm1Vlr/Adatm1Vlr
Genetic Background: either: 129P2/OlaHsd-Adatm1Vlr or (involves: (129P2/OlaHsd * FVB/N)

 MP:0005225 abnormal vertebrae development "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: C57BL/6

 MP:0005226 abnormal vertebral arch development "anomalous formation of the posterior projection from the body of a vertebra that encloses the vertebral foramen " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp4tm2Blh/Bmp4+,Bmpertm1Ysas/Bmpertm1Ysas
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0005227 abnormal vertebral body development "anomalous formation of the main portion of the vertebra anterior to the vertebral canal, and distinct from the vertebral arch" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp4tm2Blh/Bmp4+,Bmpertm1Ysas/Bmpertm1Ysas
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0005258 ocular hypertension "abnormal elevation of the intraocular pressure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005543 corneal thinning "decreased thickness of the cornea, the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pde6brd1/Pde6brgsc1754
Genetic Background: involves: C3H * C57BL/6JJcl

 MP:0006011 abnormal endolymphatic duct morphology "any structural alteration in the small membranous canal, connecting with both saccule and utricle of the membranous labyrinth, passing through the aqueduct of vestibule, and terminating in the endolymphatic sac." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL

 MP:0006020 reduced size of tympanic ring "smaller than average tympanic ring" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0006089 abnormal saccule morphology "malformation in the smaller of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL

Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Tg(Pax2-cre)1Dje/0
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * C57BL/6 * SJL

 MP:0006090 abnormal utricle morphology "malformation in the larger of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL

Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Tg(Pax2-cre)1Dje/0
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * C57BL/6 * SJL

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

 MP:0006226 iris hypoplasia "less than the normal number of cells in the iris" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0006241 abnormal placement of pupils "abnormal location of the pupil so that it is not in the center of the iris" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0006250 abnormal line of Schwalbe "malformation of the thickened peripheral margin of the vitreous membrane of the cornea" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129 * 129S6/SvEvTac

 MP:0006323 abnormal extraembryonic mesoderm development "malformation of the mesoderm of the extraembryonic tissue that is involved in forming the amnion, chorion,yolk sac, and body stalk" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: B6.129S2-Bmp4tm1Blh/J

Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: 129S2/SvPas-Bmp4tm1Blh

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0006377 abnormal vestibulocollic reflex "any anomaly in the neural reflex which results from activation of afferents from the vestibular organs and uses neck movements to stabilize the head position in space" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Gpc3Gt(Ex136)Byg/Y
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Bmp4tm1Blh/Bmp4+,Gpc3tm1Snd/Y
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm1.1Jlch
Genetic Background: B6.129-Bmp4tm1.1Jlch

Allelic Composition: Bmp4tm1.1Jlch/Bmp4+
Genetic Background: B6.129-Bmp4tm1.1Jlch

Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

Allelic Composition: Bmp4tm1Blh/Bmp4+,Tg(Prdm14-Venus)1Sait/0
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Bmp4tm1Blh/Bmp4+,Bmp8btm1Blh/Bmp8b+
Genetic Background: involves: 129/Sv * 129S2/SvPas * Black Swiss

Allelic Composition: Bmp4tm1Blh/Bmp4+,Ctdnep1tm1Ryn/Ctdnep1tm1Ryn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA

 MP:0008393 absent primordial germ cells "absence of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

Allelic Composition: Bmp4tm2Blh/Bmp4tm2Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0008488 abnormal semicircular canal ampulla morphology "any structural anomaly of the spherical enlargement at the base of each semicircular canal where they connect with the utricle, containing the crista ampullaris which detects movement of the fluid within the canals" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm4Blh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL

 MP:0008507 thin retinal ganglion layer "reduced thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0008511 thin retinal inner nuclear layer "reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: B6.129S6-Bmp4tm2Blh

 MP:0009052 anal stenosis "abnormal narrowing or constriction of the anal orifice" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129 * 129S6/SvEvTac

Allelic Composition: Bmp4tm4Blh/Bmp4+,Bmp7tm1.1Dgra/Bmp7tm1.1Dgra,Hoxa3tm1(cre)Moon/Hoxa3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0009203 external male genitalia hypoplasia "underdevelopment or reduced size of the external masculine genital organs, usually due to a reduced number of cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129 * 129S6/SvEvTac

 MP:0009252 absent urinary bladder "absence of the inflatable musculomembranous bag for holding urine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129 * 129S6/SvEvTac

Allelic Composition: Bmp4tm4Blh/Bmp4+,Bmp7tm1.1Dgra/Bmp7tm1.1Dgra,Hoxa3tm1(cre)Moon/Hoxa3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0009274 buphthalmos "abnormal enlargement of the eye that is usually congenital and attended by symptoms of glaucoma" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: involves: 129S2/SvPas * C3Hf/HeA * C57BL/LiA

 MP:0009576 oral atresia "congenital blockage, fusion, or absence of the normal opening of the oral cavity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

 MP:0009743 preaxial polydactyly "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]
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Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm1.1Jlch
Genetic Background: B6.129-Bmp4tm1.1Jlch

 MP:0009874 abnormal interdigital cell death "change in the expected number of cells undergoing programmed cell death (apoptosis) in the autopod during development, precluding the sculpting of normal digits" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * SJL

 MP:0009905 absent tongue "absence of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

 MP:0010098 abnormal retinal blood vessel pattern "anomaly in the systematic arrangement of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0010117 abnormal lateral plate mesoderm "anomaly of the portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ush1cdfcr/Ush1cdfcr
Genetic Background: involves: BALB/cByJ

 MP:0010224 abnormal heart ventricle outflow tract morphology "any structural anomaly of the superior portion of the ventricles of the heart through which blood flows into the arteries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Adartm1Olds/Adartm1Olds
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/?,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(Mef2c-cre)2Blk/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0010252 anterior subcapsular cataracts "a lens opacity localized beneath the anterior lens capsule" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0010256 anterior cortical cataracts "a lens opacity, frequently punctate, affecting the anterior pole of the lens cortex in which spokes or wedges progressively extend from the outside of the lens towards the center" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
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Allelic Composition: Thratm1Brnt/Thra+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010404 ostium primum atrial septal defect "interatrial communication (atrial septal defect) through the most anterior and inferior aspect of the atrial septum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * ICR

 MP:0010413 complete atrioventricular septal defect "a type of atrioventricular septal defect in which a single atrioventricular valve annulus, a common atrioventricular valve, and a defect of the inlet ventricular septum are observed; deficiency of the atrioventricular septum also results in the presence of a large primum atrial septal defect" [http://emedicine.medscape.com]
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Allelic Composition: Thratm1Brnt/Thra+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010414 partial atrioventricular septal defect "a type of atrioventricular septal defect in which the endocardial cushion defects present have an interatrial communication but lack an interventricular communication; the mitral and tricuspid annuli are separate but one or more additional features are present, including primum atrial septal defect (ASD), inlet ventricular septal defect (VSD), cleft of the anterior mitral valve leaflet, and wide anteroseptal tricuspid valve commissure or cleft septal tricuspid leaflet" [http://emedicine.medscape.com]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * ICR

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: B6.129S6-Bmp4tm2Blh

Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0010426 abnormal heart and great artery attachment "any anomaly in the in the position or pattern of the connection site of the heart to any of the great arteries, including the pulmonary artery and aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

 MP:0010454 abnormal truncus arteriosis septation "anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

 MP:0010455 aortopulmonary window "a defect between the great vessels that results from failure of the conotruncal ridges to fuse resulting in an abnormal communication between the aorta and the pulmonary arteries" [http://emedicine.medscape.com]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0010464 abnormal aortic arch and aortic arch branch attachment "any anomaly of the connection site of the aortic branches to the aortic arch, including the attachment sites for the left common carotid artery, the left subclavian artery, and the brachiocephalic trunk which further splits to form the right subclavian artery and the right common carotid artery" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0010585 abnormal conotruncal ridge morphology "any structural anomaly of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0010587 conotruncal ridge hypoplasia "underdevelopment or reduced size of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8823298]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0010607 common atrioventricular valve "the presence of a single atrioventricular valve instead of both a mitral and tricuspid valve, most commonly due to incomplete or failure of fetal atrioventricular canal septation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Thratm1Brnt/Thra+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010656 thick myocardium "increased thickness of the heart muscle layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/?,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(Mef2c-cre)2Blk/?
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

 MP:0010755 abnormal heart right ventricle pressure "any anomaly in the pressure within the right cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pde6brd1/Pde6brgsc1754
Genetic Background: involves: C3H * C57BL/6JJcl

 MP:0010980 ectopic ureteric bud "ureteric bud(s) are not located in the normal or expected position" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0010982 abnormal ureteric bud elongation "any anomaly in the process in which a ureteric bud grows along its axis" [GO:0060677]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0010984 abnormal metanephric mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing metanephros; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:19828308]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0010985 abnormal kidney mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing kidney" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss * ICR

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: B6.129S6-Bmp4tm2Blh

Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * Black Swiss

Allelic Composition: Bmp4tm1Blh/Bmp4tm3.1Blh,Tg(Tnnt2-cre)5Blh/0
Genetic Background: involves: 129S/Sv * Black Swiss * C57BL/6 * DBA/2 * ICR

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

Allelic Composition: Bmp4tm5.1Bhr/Bmp4tm5.1Bhr
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster

Allelic Composition: Bmp4tm5.1Bhr/Bmp4tm2.1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * Swiss Webster

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: B6.129S2-Bmp4tm1Blh/J

Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: 129S2/SvPas-Bmp4tm1Blh

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: involves: 129S2/SvPas * ICR

Allelic Composition: Bmp4tm3Blh/Bmp4tm3Blh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Bmp4tm2Blh/Bmp4tm2Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Bmp4tm3Blh/Bmp4tm3Blh
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Bmp4tm3Blh/Bmp4+,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Bmp4tm3Blh/Bmp4tm3Blh
Genetic Background: involves: 129S6/SvEvTac

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0011199 abnormal amniotic cavity morphology "any structural anomaly of the closed space between the embryo and the amnion, containing the amniotic fluid; it is formed by the fusion of the parts of the anterior and posterior amniotic folds" [ISBN:0-12-402035-6]
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Allelic Composition: Ush1cdfcr/Ush1cdfcr
Genetic Background: involves: BALB/cByJ

 MP:0011260 abnormal head mesenchyme morphology "any structural anomaly of the primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells" [ISBN:0-683-40008-8]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0011264 abnormal cardiac mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0011305 dilated kidney calyx "an expansion in the lumen volume or area of any of the branches of the renal pelvis that surround each renal papilla and collect urine" [MGI:anna]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0011334 abnormal nephrogenic zone morphology "any structural anomaly in the region found at the periphery of the developing metanephros within which the metanephric mesenchyme aggregates around the tips of the ureteric tree to form the nephrons; in rodents including mice, this region normally disappears within the first postnatal week when nephrogenesis ceases and only mature nephrons are present; in humans, it is lost by 36 weeks of gestation" [PMID:17452023]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0011386 increased metanephric mesenchyme apoptosis "increase in the number of cells of the metanephric mesenchyme (MM) undergoing programmed cell death; usually due to failure of MM cells to interact with the ureteric bud (UB) tips after UB invasion" [MGI:anna]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0011426 abnormal ureter smooth muscle morphology "any structural anomaly of the smooth muscle tissue surrounding the epithelium of the ureter" [MGI:anna]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0011481 anterior iris synechia "adhesion of the iris to the cornea" [MGI:anna]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0011486 ectopic ureter "an abnormally placed opening of the ureter, either into the urinary bladder or at another site in the lower urinary or genital tract" [MGI:anna]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0011488 abnormal ureterovesical junction morphology "any structural anomaly of the valve-like structure found at the site of entry of the ureter into the urinary bladder, normally displays an oblique angulation through the detrusor to avoid reflux of urine up the ureters and the kidney" [MGI:csmith]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0011711 decreased osteoblast differentiation 
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0011759 absent Rathke s pouch "absence of the diverticulum arsing from the embryonic buccal cavity from which the anterior lobe of the pituitary gland is developed" [MGI:anna]
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Allelic Composition: Foxc2tm1Miu/Foxc2tm1Miu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011783 abnormal ureteral orifice morphology "any structural anomaly of the slit-like opening of either ureter into the bladder; normally, the two ureteral orifices are placed at the posterolateral angles of the urinary bladder trigone while the internal urethral orifice is placed at its anteroinferior angle (apex); wide gaping usually indicates vesicoureteral reflux" [MGI:anna]
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Allelic Composition: Bmp4tm2Blh/Bmp4+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6J

 MP:0011851 abnormal embryonic cloaca development "failure or anomaly in the formation of a pouch-like dilation of the caudal end of the hindgut by the process of folding of the caudal region of the embryonic disk; during the tail-fold process, the posteriorly placed allantois, or allantoic diverticulum of the yolk sac, becomes an anterior extension of the cloaca; soon after the cloaca forms, it receives posterolaterally the caudal ends of the paired mesonephric ducts and hence becomes a junctional cistern for the allantois, the hindgut, and the ducts; a cloacal membrane, composed of ectoderm and endoderm, is the caudal limit of the primitive gut and temporarily separates the cloacal cavity from the extraembryonic confines of the amniotic cavity; subsequent growth of the urorectal septum eventually subdivides the once single cloaca chamber into the primitive urogenital sinus (ventrally) and the anorectal canal of the hindgut (dorsally)" [MGI:anna]
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Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129 * 129S6/SvEvTac

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Bmp4tm1Blh/Bmp4+
Genetic Background: B6.129S2-Bmp4tm1Blh/J

 MP:0012235 abnormal liver bud morphology "any structural anomaly of the liver primordium formed as hepatoblasts delaminate from the anterior portion of the hepatic diverticulum and invade the adjacent septum transversum mesenchyme" [MGI:anna]
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Allelic Composition: Bmp4tm2Blh/Bmp4tm2Blh
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0012740 abnormal posterior primitive streak morphology "any structural anomaly of the posterior region of the vertebrate primitive streak which gives rise to the extraembryonic mesoderm" [MGI:anna]
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Allelic Composition: Ush1cdfcr/Ush1cdfcr
Genetic Background: involves: BALB/cByJ

 MP:0013167 abnormal hindlimb bud morphology "any structural anomaly of the limb bud that develops into a hindlimb (usually the leg or back limb in mammalian species)" [MGI:anna]
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Allelic Composition: Bmp4tm4Blh/Bmp4tm4Blh,Isl1tm1(cre)Sev/Isl1+
Genetic Background: involves: 129 * 129S6/SvEvTac

 MP:0013283 failure of ventral body wall closure "failure of the lateral body wall folds (a combination of mesoderm and ectoderm arising on each side of the embryo) to progress ventrally and meet in the midline and/or fuse to close the ventral body wall; normally, this closure is aided by growth of the head and tail folds that cause the embryo to curve into the fetal position and is complete except in the region of the connecting stalk (future umbilical cord); if closure fails, ventral body wall defects occur in the thorax, abdomen, and pelvis and involve the heart (ectopia cordis), abdominal viscera (gastroschisis), and/or urogenital organs (bladder or cloacal exstrophy), depending upon the location and size of the abnormality" [http://www.nbdpn.org/current/2008pdf/AMPresentations/EmbryologySadler.pdf, https://www.inkling.com/read/langmans-medical-embryology-thomas-sadler-12th/chapter-7/ch07-clinical-correlates-01, MGI:anna]
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Allelic Composition: Bmp4tm1.1Jlch/Bmp4tm2Blh
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0013790 single external naris "presence of only one anterior opening to the nasal cavity as opposed to the normal two; usually associated with midline facial defects arising from cleavage anomalies" [MGI:Anna]
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Allelic Composition: Bmp4tm1Blh/Bmp4+,Twsg1tm1Emdr/Twsg1tm1Emdr
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * SJL

 MP:0020516 abnormal visceral yolk sac mesenchyme morphology "any structural anomaly of the portion of the visceral yolk sac that is derived from mesoderm and consists of mesenchyme" [UBERON:0003316]
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Allelic Composition: Bmp4tm1Blh/Bmp4tm1Blh
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0030066 short face "an abnormally decreased height (length) of the face" [MGI:anna]
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0030121 small temporal bone squamous part "reduced size of the anterosuperior portion of the temporal bone that is thin, scale-like, and translucent and forms part of the lateral wall of the cranial vault" [MGI:anna]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4+,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Bmp2tm1Jfm/Bmp2+,Bmp4tm1Jfm/Bmp4tm1Jfm,Bmp7tm1Jfm/Bmp7tm1Jfm,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

 MP:0030245 round head "overall shape of the head is more circular than usual as viewed from the front" [MGI:anna]
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0030283 small mandibular coronoid process "reduced size of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion)" [MGI:anna]
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

 MP:0030313 abnormal face development "any anomaly in the process in which the anatomical structures of the face are generated and organized" [GO:0060325]
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Allelic Composition: Bmp4tm3Blh/Bmp4tm3Blh,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0030372 enlarged Meckel s cartilage "increased size of the cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible and gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [MGI:anna]
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Allelic Composition: Bmp4tm2(tetO-Bmp4,lacZ)Jfm/Bmp4+,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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