ENSGALG00000012429


Gallus gallus

Features
Gene ID: ENSGALG00000012429
  
Biological name :BMP4
  
Synonyms : BMP4 / bone morphogenetic protein 4
  
Possible biological names infered from orthology : Bone morphotic protein 4 / P12644 / P21275
  
Species: Gallus gallus
  
Chr. number: 5
Strand: -1
Band:
Gene start: 58698105
Gene end: 58700937
  
Corresponding Affymetrix probe sets: Gga.10863.1.S1_at (Chicken Array)   Gga.10863.1.S1_s_at (Chicken Array)   Gga.686.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000020289
Ensembl peptide - ENSGALP00000058867
NCBI entrez gene - 396165     See in Manteia.
RefSeq - NM_205237
RefSeq Peptide - NP_990568
swissprot - E1C0T2
swissprot - A0A1L1RJE2
Ensembl - ENSGALG00000012429
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmp4ENSDARG00000019995Danio rerio
 BMP4ENSG00000125378Homo sapiens
 Bmp4ENSMUSG00000021835Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BMP2 / bone morphogenetic protein 2 precursor / P12643* / P21274* / Bone morphotic protein 2 * / bone morphogenetic protein 2*ENSGALG0000002930161
BMP7 / bone morphogenetic protein 7 / P18075* / P23359* / Bone morphotic protein 7 *ENSGALG0000000766832
BMP8B* / BMP8A* / Q7Z5Y6* / P34820* / P34821* / P55105* / Bone morphotic protein 8A * / Bone morphotic protein 8B * / bone morphogenetic protein 8a* / bone morphogenetic protein 8b*ENSGALG0000003898432
BMP5 / bone morphogenetic protein 5 / P22003* / P49003* / Bone morphotic protein 5 *ENSGALG0000001629332
GDF2 / P34822 / Dorsalin-1 / Q9WV56* / Q9UK05* / growth differentiation factor 2*ENSGALG0000000598129
BMP10 / bone morphogenetic protein 10 / O95393* / Q9R229* / Bone morphotic protein 10 *ENSGALG0000000012029
ADMP / anti-dorsalizing morphogenetic protein precursor ENSGALG0000003740828
GDF5 / growth/differentiation factor 5 precursor / P43026* / P43027* / growth differentiation factor 5*ENSGALG0000003835527
BMP6 / bone morphogenetic protein 6 / P20722* / P22004* / Bone morphotic protein 6 *ENSGALG0000001278726
ENSGALG0000000623925
GDF6 / growth differentiation factor 6 / P43028* / Q6KF10*ENSGALG0000003590124


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001656 metanephros development IEA
 biological_processGO:0001657 ureteric bud development IEA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0001707 mesoderm formation IEA
 biological_processGO:0001759 organ induction IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001823 mesonephros development IEA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0001944 vasculature development IEA
 biological_processGO:0001958 endochondral ossification IEA
 biological_processGO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis IEA
 biological_processGO:0002062 chondrocyte differentiation IEA
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0002320 lymphoid progenitor cell differentiation IEA
 biological_processGO:0003014 renal system process IEA
 biological_processGO:0003130 BMP signaling pathway involved in heart induction IEA
 biological_processGO:0003139 secondary heart field specification IEA
 biological_processGO:0003148 outflow tract septum morphogenesis IEA
 biological_processGO:0003149 membranous septum morphogenesis IEA
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0003180 aortic valve morphogenesis IEA
 biological_processGO:0003184 pulmonary valve morphogenesis IEA
 biological_processGO:0003197 endocardial cushion development IEA
 biological_processGO:0003323 type B pancreatic cell development IEA
 biological_processGO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis IEA
 biological_processGO:0007182 common-partner SMAD protein phosphorylation IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007281 germ cell development IEA
 biological_processGO:0007492 endoderm development IEA
 biological_processGO:0007500 mesodermal cell fate determination IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0009888 tissue development IEA
 biological_processGO:0009948 anterior/posterior axis specification IEA
 biological_processGO:0010159 specification of animal organ position IEA
 biological_processGO:0010453 regulation of cell fate commitment IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0021537 telencephalon development IEA
 biological_processGO:0021904 dorsal/ventral neural tube patterning IEA
 biological_processGO:0021978 telencephalon regionalization IEA
 biological_processGO:0021983 pituitary gland development IEA
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0030224 monocyte differentiation IEA
 biological_processGO:0030225 macrophage differentiation IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030326 embryonic limb morphogenesis IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032331 negative regulation of chondrocyte differentiation IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0033085 negative regulation of T cell differentiation in thymus IEA
 biological_processGO:0033088 negative regulation of immature T cell proliferation in thymus IEA
 biological_processGO:0034504 protein localization to nucleus IEA
 biological_processGO:0035116 embryonic hindlimb morphogenesis IEA
 biological_processGO:0035990 tendon cell differentiation IEA
 biological_processGO:0035993 deltoid tuberosity development IEA
 biological_processGO:0042306 regulation of protein import into nucleus IEA
 biological_processGO:0042326 negative regulation of phosphorylation IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042476 odontogenesis IEA
 biological_processGO:0042487 regulation of odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042733 embryonic digit morphogenesis IEA
 biological_processGO:0043010 camera-type eye development IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 biological_processGO:0045165 cell fate commitment IEA
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045603 positive regulation of endothelial cell differentiation IEA
 biological_processGO:0045606 positive regulation of epidermal cell differentiation IEA
 biological_processGO:0045662 negative regulation of myoblast differentiation IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045778 positive regulation of ossification IEA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0045839 negative regulation of mitotic nuclear division IEA
 biological_processGO:0045843 negative regulation of striated muscle tissue development IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048286 lung alveolus development IEA
 biological_processGO:0048333 mesodermal cell differentiation IEA
 biological_processGO:0048392 intermediate mesodermal cell differentiation IEA
 biological_processGO:0048593 camera-type eye morphogenesis IEA
 biological_processGO:0048598 embryonic morphogenesis IEA
 biological_processGO:0048646 anatomical structure formation involved in morphogenesis IEA
 biological_processGO:0048660 regulation of smooth muscle cell proliferation IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0048663 neuron fate commitment IEA
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IEA
 biological_processGO:0048704 embryonic skeletal system morphogenesis IEA
 biological_processGO:0048706 embryonic skeletal system development IEA
 biological_processGO:0048745 smooth muscle tissue development IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0051145 smooth muscle cell differentiation IEA
 biological_processGO:0051150 regulation of smooth muscle cell differentiation IEA
 biological_processGO:0055007 cardiac muscle cell differentiation IEA
 biological_processGO:0055020 positive regulation of cardiac muscle fiber development IEA
 biological_processGO:0060113 inner ear receptor cell differentiation IEA
 biological_processGO:0060197 cloacal septation IEA
 biological_processGO:0060235 lens induction in camera-type eye IEA
 biological_processGO:0060272 embryonic skeletal joint morphogenesis IEA
 biological_processGO:0060348 bone development IEA
 biological_processGO:0060363 cranial suture morphogenesis IEA
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction IEA
 biological_processGO:0060393 regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0060395 SMAD protein signal transduction IEA
 biological_processGO:0060425 lung morphogenesis IEA
 biological_processGO:0060429 epithelium development IEA
 biological_processGO:0060433 bronchus development IEA
 biological_processGO:0060438 trachea development IEA
 biological_processGO:0060440 trachea formation IEA
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis IEA
 biological_processGO:0060442 branching involved in prostate gland morphogenesis IEA
 biological_processGO:0060449 bud elongation involved in lung branching IEA
 biological_processGO:0060502 epithelial cell proliferation involved in lung morphogenesis IEA
 biological_processGO:0060503 bud dilation involved in lung branching IEA
 biological_processGO:0060512 prostate gland morphogenesis IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0060592 mammary gland formation IEA
 biological_processGO:0060684 epithelial-mesenchymal cell signaling IEA
 biological_processGO:0060686 negative regulation of prostatic bud formation IEA
 biological_processGO:0060687 regulation of branching involved in prostate gland morphogenesis IEA
 biological_processGO:0060688 regulation of morphogenesis of a branching structure IEA
 biological_processGO:0060976 coronary vasculature development IEA
 biological_processGO:0061035 regulation of cartilage development IEA
 biological_processGO:0061036 positive regulation of cartilage development IEA
 biological_processGO:0061047 positive regulation of branching involved in lung morphogenesis IEA
 biological_processGO:0061149 BMP signaling pathway involved in ureter morphogenesis IEA
 biological_processGO:0061151 BMP signaling pathway involved in renal system segmentation IEA
 biological_processGO:0061155 pulmonary artery endothelial tube morphogenesis IEA
 biological_processGO:0061312 BMP signaling pathway involved in heart development IEA
 biological_processGO:0061626 pharyngeal arch artery morphogenesis IEA
 biological_processGO:0070244 negative regulation of thymocyte apoptotic process IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:0071893 BMP signaling pathway involved in nephric duct formation IEA
 biological_processGO:0072001 renal system development IEA
 biological_processGO:0072015 glomerular visceral epithelial cell development IEA
 biological_processGO:0072097 negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway IEA
 biological_processGO:0072101 specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway IEA
 biological_processGO:0072104 glomerular capillary formation IEA
 biological_processGO:0072125 negative regulation of glomerular mesangial cell proliferation IEA
 biological_processGO:0072138 mesenchymal cell proliferation involved in ureteric bud development IEA
 biological_processGO:0072161 mesenchymal cell differentiation involved in kidney development IEA
 biological_processGO:0072192 ureter epithelial cell differentiation IEA
 biological_processGO:0072193 ureter smooth muscle cell differentiation IEA
 biological_processGO:0072198 mesenchymal cell proliferation involved in ureter development IEA
 biological_processGO:0072200 negative regulation of mesenchymal cell proliferation involved in ureter development IEA
 biological_processGO:0072205 metanephric collecting duct development IEA
 biological_processGO:0090184 positive regulation of kidney development IEA
 biological_processGO:0090191 negative regulation of branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0090194 negative regulation of glomerulus development IEA
 biological_processGO:1901964 positive regulation of cell proliferation involved in outflow tract morphogenesis IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA IEA
 biological_processGO:1905312 positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis IEA
 biological_processGO:2000005 negative regulation of metanephric S-shaped body morphogenesis IEA
 biological_processGO:2000007 negative regulation of metanephric comma-shaped body morphogenesis IEA
 biological_processGO:2000105 positive regulation of DNA-dependent DNA replication IEA
 biological_processGO:2000137 negative regulation of cell proliferation involved in heart morphogenesis IEA
 biological_processGO:2001012 mesenchymal cell differentiation involved in renal system development IEA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0039706 co-receptor binding IEA
 molecular_functionGO:0042056 chemoattractant activity IEA
 molecular_functionGO:0070700 BMP receptor binding IEA


Pathways (from Reactome)
Pathway description
Molecules associated with elastic fibres
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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