ENSGALG00000005981


Gallus gallus

Features
Gene ID: ENSGALG00000005981
  
Biological name :GDF2
  
Synonyms : Dorsalin-1 / GDF2 / P34822
  
Possible biological names infered from orthology : growth differentiation factor 2 / Q9UK05 / Q9WV56
  
Species: Gallus gallus
  
Chr. number: 6
Strand: -1
Band:
Gene start: 18011390
Gene end: 18014610
  
Corresponding Affymetrix probe sets: Gga.811.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000009606
NCBI entrez gene - 396412     See in Manteia.
RefSeq - NM_205432
RefSeq Peptide - NP_990763
swissprot - P34822
Ensembl - ENSGALG00000005981
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gdf2ENSDARG00000059173Danio rerio
 GDF2ENSG00000263761Homo sapiens
 Gdf2ENSMUSG00000072625Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BMP10 / bone morphogenetic protein 10 / O95393* / Q9R229* / Bone morphotic protein 10 *ENSGALG0000000012044
BMP4 / bone morphogenetic protein 4 / P12644* / P21275* / Bone morphotic protein 4 *ENSGALG0000001242928
BMP5 / bone morphogenetic protein 5 / P22003* / P49003* / Bone morphotic protein 5 *ENSGALG0000001629326
BMP2 / bone morphogenetic protein 2 precursor / P12643* / P21274* / Bone morphotic protein 2 * / bone morphogenetic protein 2*ENSGALG0000002930126
BMP7 / bone morphogenetic protein 7 / P18075* / P23359* / Bone morphotic protein 7 *ENSGALG0000000766826
BMP8B* / BMP8A* / Q7Z5Y6* / P34820* / P34821* / P55105* / Bone morphotic protein 8A * / Bone morphotic protein 8B * / bone morphogenetic protein 8a* / bone morphogenetic protein 8b*ENSGALG0000003898424
GDF5 / growth/differentiation factor 5 precursor / P43026* / P43027* / growth differentiation factor 5*ENSGALG0000003835523
ADMP / anti-dorsalizing morphogenetic protein precursor ENSGALG0000003740822
ENSGALG0000000623921
BMP6 / bone morphogenetic protein 6 / P20722* / P22004* / Bone morphotic protein 6 *ENSGALG0000001278721
GDF6 / growth differentiation factor 6 / P43028* / Q6KF10*ENSGALG0000003590120


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IEA
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010596 negative regulation of endothelial cell migration IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IEA
 biological_processGO:0032757 positive regulation of interleukin-8 production IEA
 biological_processGO:0032924 activin receptor signaling pathway IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045603 positive regulation of endothelial cell differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0048514 blood vessel morphogenesis IEA
 biological_processGO:0060389 pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 biological_processGO:0061036 positive regulation of cartilage development IEA
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:2000279 negative regulation of DNA biosynthetic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000035635 ACVRL1 / activin A receptor like type 1 / P37023* / Q61288* / Serine/threonine-protein kinase receptor R3 *  / complex / reaction
 ENSGALG00000005981 GDF2 / P34822 / Dorsalin-1 / Q9WV56* / Q9UK05* / growth differentiation factor 2*  / complex






 

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