ENSGALG00000035635


Gallus gallus

Features
Gene ID: ENSGALG00000035635
  
Biological name :ACVRL1
  
Synonyms : activin A receptor like type 1 / ACVRL1
  
Possible biological names infered from orthology : P37023 / Q61288 / Serine/threonine-protein kinase receptor R3
  
Species: Gallus gallus
  
Chr. number: 33
Strand: -1
Band:
Gene start: 25756
Gene end: 32131
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSGALP00000047403
NCBI entrez gene - 100857446     See in Manteia.
RefSeq - XM_015300268
swissprot - A0A1D5P3Z7
Ensembl - ENSGALG00000035635
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acvrl1ENSDARG00000018179Danio rerio
 ACVRL1ENSG00000139567Homo sapiens
 Acvrl1ENSMUSG00000000530Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACVR1 / Q90ZK6 / Activin receptor type-1 / Q04771* / P37172* / activin A receptor type 1* / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA.*ENSGALG0000003730159
TGFBR1 / transforming growth factor beta receptor 1 / P36897* / Q64729* / transforming growth factor, beta receptor I*ENSGALG0000003317948
ACVR1B / activin A receptor type 1B / P36896* / Q61271* / Activin receptor type-1B *ENSGALG0000002959947
ACVR1C / activin A receptor type 1C / Q8K348* / Q8NER5* / Activin receptor type-1C *ENSGALG0000004125746
BMPR1B / bone morphogenetic protein receptor type-1B precursor / O00238* / P36898* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B (B...ENSGALG0000001221645
BMPR1A / bone morphogenetic protein receptor type-1A precursor / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*ENSGALG0000000200345
ACVR2B / activin receptor type-2B precursor / P27040* / Q13705* / Activin receptor type-2B * / activin A receptor type 2B*ENSGALG0000000615829
Q90999 / TGFBR2 / TGF-beta receptor type-2 / Q62312* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*ENSGALG0000001144228
BMPR2 / bone morphogenetic protein receptor type 2 / O35607* / Q13873* / Bone morphotic protein receptor type-2 *ENSGALG0000000845928
ENSGALG0000001205527
ACVR2A / Q90669 / Activin receptor type-2A / P27037* / P27038* / activin A receptor type 2A*ENSGALG0000001244427


Protein motifs (from Interpro)
Interpro ID Name
 IPR000333  Ser/Thr protein kinase, TGFB receptor
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003605  GS domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0001946 lymphangiogenesis IEA
 biological_processGO:0001974 blood vessel remodeling IEA
 biological_processGO:0003203 endocardial cushion morphogenesis IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0008015 blood circulation IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010596 negative regulation of endothelial cell migration IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IEA
 biological_processGO:0035313 wound healing, spreading of epidermal cells IEA
 biological_processGO:0035912 dorsal aorta morphogenesis IEA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045602 negative regulation of endothelial cell differentiation IEA
 biological_processGO:0045603 positive regulation of endothelial cell differentiation IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048514 blood vessel morphogenesis IEA
 biological_processGO:0051895 negative regulation of focal adhesion assembly IEA
 biological_processGO:0060836 lymphatic endothelial cell differentiation IEA
 biological_processGO:0060840 artery development IEA
 biological_processGO:0060841 venous blood vessel development IEA
 biological_processGO:0061154 endothelial tube morphogenesis IEA
 biological_processGO:0061298 retina vasculature development in camera-type eye IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:2000279 negative regulation of DNA biosynthetic process IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity IEA
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0005024 transforming growth factor beta-activated receptor activity IEA
 molecular_functionGO:0005025 transforming growth factor beta receptor activity, type I IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016361 activin receptor activity, type I IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0048185 activin binding IEA
 molecular_functionGO:0050431 transforming growth factor beta binding IEA
 molecular_functionGO:0098821 BMP receptor activity IEA


Pathways (from Reactome)
Pathway description
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000120 BMP10 / bone morphogenetic protein 10 / O95393* / Q9R229* / Bone morphotic protein 10 *  / reaction / complex
 ENSGALG00000005981 GDF2 / P34822 / Dorsalin-1 / Q9WV56* / Q9UK05* / growth differentiation factor 2*  / complex / reaction






 

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