ENSGALG00000002003


Gallus gallus

Features
Gene ID: ENSGALG00000002003
  
Biological name :BMPR1A
  
Synonyms : BMPR1A / bone morphogenetic protein receptor type-1A precursor
  
Possible biological names infered from orthology : bone morphogenetic protein receptor type 1A / Bone morphotic protein receptor type-1A / P36894 / P36895
  
Species: Gallus gallus
  
Chr. number: 6
Strand: 1
Band:
Gene start: 2497710
Gene end: 2573153
  
Corresponding Affymetrix probe sets: Gga.755.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000003114
Ensembl peptide - ENSGALP00000053837
NCBI entrez gene - 396308     See in Manteia.
RefSeq - XM_015287961
RefSeq - NM_205357
RefSeq - XM_015287960
RefSeq Peptide - NP_990688
swissprot - F1P3H0
Ensembl - ENSGALG00000002003
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bmpr1aaENSDARG00000019728Danio rerio
 bmpr1abENSDARG00000105045Danio rerio
 BMPR1AENSG00000107779Homo sapiens
 Bmpr1aENSMUSG00000021796Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BMPR1B / bone morphogenetic protein receptor type-1B precursor / O00238* / P36898* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B (B...ENSGALG0000001221668
TGFBR1 / transforming growth factor beta receptor 1 / P36897* / Q64729* / transforming growth factor, beta receptor I*ENSGALG0000003317948
ACVR1B / activin A receptor type 1B / P36896* / Q61271* / Activin receptor type-1B *ENSGALG0000002959947
ACVR1C / activin A receptor type 1C / Q8K348* / Q8NER5* / Activin receptor type-1C *ENSGALG0000004125746
ACVR1 / Q90ZK6 / Activin receptor type-1 / Q04771* / P37172* / activin A receptor type 1* / Mus musculus activin A receptor, type 1 (Acvr1), transcript variant 5, mRNA.*ENSGALG0000003730145
ACVRL1 / activin A receptor like type 1 / P37023* / Q61288* / Serine/threonine-protein kinase receptor R3 *ENSGALG0000003563542
ACVR2A / Q90669 / Activin receptor type-2A / P27037* / P27038* / activin A receptor type 2A*ENSGALG0000001244428
ACVR2B / activin receptor type-2B precursor / P27040* / Q13705* / Activin receptor type-2B * / activin A receptor type 2B*ENSGALG0000000615827
Q90999 / TGFBR2 / TGF-beta receptor type-2 / Q62312* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*ENSGALG0000001144227
ENSGALG0000001205526
BMPR2 / bone morphogenetic protein receptor type 2 / O35607* / Q13873* / Bone morphotic protein receptor type-2 *ENSGALG0000000845926


Protein motifs (from Interpro)
Interpro ID Name
 IPR000333  Ser/Thr protein kinase, TGFB receptor
 IPR000472  Activin types I and II receptor domain
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003605  GS domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001707 mesoderm formation IEA
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0001880 Mullerian duct regression IEA
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IEA
 biological_processGO:0002062 chondrocyte differentiation IEA
 biological_processGO:0003007 heart morphogenesis IEA
 biological_processGO:0003148 outflow tract septum morphogenesis IEA
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0003161 cardiac conduction system development IEA
 biological_processGO:0003183 mitral valve morphogenesis IEA
 biological_processGO:0003186 tricuspid valve morphogenesis IEA
 biological_processGO:0003203 endocardial cushion morphogenesis IEA
 biological_processGO:0003215 cardiac right ventricle morphogenesis IEA
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IEA
 biological_processGO:0003223 ventricular compact myocardium morphogenesis IEA
 biological_processGO:0003272 endocardial cushion formation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0007389 pattern specification process IEA
 biological_processGO:0007398 ectoderm development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007492 endoderm development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0009950 dorsal/ventral axis specification IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IEA
 biological_processGO:0014032 neural crest cell development IEA
 biological_processGO:0014912 negative regulation of smooth muscle cell migration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0021983 pituitary gland development IEA
 biological_processGO:0021998 neural plate mediolateral regionalization IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0035137 hindlimb morphogenesis IEA
 biological_processGO:0035912 dorsal aorta morphogenesis IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042733 embryonic digit morphogenesis IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048339 paraxial mesoderm development IEA
 biological_processGO:0048352 paraxial mesoderm structural organization IEA
 biological_processGO:0048368 lateral mesoderm development IEA
 biological_processGO:0048378 regulation of lateral mesodermal cell fate specification IEA
 biological_processGO:0048382 mesendoderm development IEA
 biological_processGO:0048568 embryonic organ development IEA
 biological_processGO:0048589 developmental growth IEA
 biological_processGO:0048598 embryonic morphogenesis IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050768 negative regulation of neurogenesis IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060043 regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060391 positive regulation of SMAD protein signal transduction IEA
 biological_processGO:0060896 neural plate pattern specification IEA
 biological_processGO:0060914 heart formation IEA
 biological_processGO:0061626 pharyngeal arch artery morphogenesis IEA
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1904414 positive regulation of cardiac ventricle development IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1905285 fibrous ring of heart morphogenesis IEA
 biological_processGO:2000772 regulation of cellular senescence IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0044214 spanning component of plasma membrane TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004675 transmembrane receptor protein serine/threonine kinase activity IEA
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0098821 BMP receptor activity IEA


Pathways (from Reactome)
Pathway description
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002003 BMPR1A / bone morphogenetic protein receptor type-1A precursor / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*  / reaction / complex
 ENSGALG00000017050 SMAD9 / mothers against decapentaplegic homolog 9 / O15198* / Q9JIW5* / SMAD family member 9*  / reaction / complex
 ENSGALG00000004655 SMURF1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *  / complex / reaction
 ENSGALG00000006309 SMAD5 / Q56I99 / Mothers against decapentaplegic homolog 5 / P97454* / Q99717* / SMAD family member 5*  / reaction / complex
 ENSGALG00000015576 ZFYVE16 / zinc finger FYVE-type containing 16 / Q7Z3T8* / Q80U44* / zinc finger, FYVE domain containing 16*  / reaction / complex
 ENSGALG00000006158 ACVR2B / activin receptor type-2B precursor / P27040* / Q13705* / Activin receptor type-2B * / activin A receptor type 2B*  / reaction / complex
 ENSGALG00000009977 SMAD1 / mothers against decapentaplegic homolog 1 / P70340* / Q15797* / SMAD family member 1*  / reaction / complex
 ENSGALG00000003566 SMURF2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *  / reaction / complex
 ENSGALG00000029301 BMP2 / bone morphogenetic protein 2 precursor / P12643* / P21274* / Bone morphotic protein 2 * / bone morphogenetic protein 2*  / reaction / complex
 ENSGALG00000012444 ACVR2A / Q90669 / Activin receptor type-2A / P27037* / P27038* / activin A receptor type 2A*  / reaction / complex
 ENSGALG00000012216 BMPR1B / bone morphogenetic protein receptor type-1B precursor / O00238* / P36898* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B (B...  / complex / reaction
 ENSGALG00000008459 BMPR2 / bone morphogenetic protein receptor type 2 / O35607* / Q13873* / Bone morphotic protein receptor type-2 *  / reaction / complex






 

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