ENSGALG00000006309


Gallus gallus

Features
Gene ID: ENSGALG00000006309
  
Biological name :SMAD5
  
Synonyms : Mothers against decapentaplegic homolog 5 / Q56I99 / SMAD5
  
Possible biological names infered from orthology : P97454 / Q99717 / SMAD family member 5
  
Species: Gallus gallus
  
Chr. number: 13
Strand: -1
Band:
Gene start: 15169675
Gene end: 15176983
  
Corresponding Affymetrix probe sets: Gga.4133.1.S1_at (Chicken Array)   Gga.4133.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050262
Ensembl peptide - ENSGALP00000039387
NCBI entrez gene - 395679     See in Manteia.
RefSeq - XM_015293968
RefSeq - NM_001014968
RefSeq - XM_015293966
RefSeq - XM_015293967
RefSeq Peptide - NP_001014968
swissprot - A0A1D5PBY0
swissprot - Q56I99
Ensembl - ENSGALG00000006309
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smad1ENSDARG00000027199Danio rerio
 smad5ENSDARG00000037238Danio rerio
 SMAD5ENSG00000113658Homo sapiens
 Smad5ENSMUSG00000021540Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SMAD1 / mothers against decapentaplegic homolog 1 / P70340* / Q15797* / SMAD family member 1*ENSGALG0000000997791
SMAD9 / mothers against decapentaplegic homolog 9 / O15198* / Q9JIW5* / SMAD family member 9*ENSGALG0000001705080
SMAD2Z / SMAD2* / Q62432* / Q15796* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *ENSGALG0000003600162
SMAD2* / Q15796* / Q62432* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *ENSGALG0000001418462
SMAD3 / mothers against decapentaplegic homolog 3 / P84022* / Q8BUN5* / SMAD family member 3*ENSGALG0000003570161
SMAD4* / P97471* / Q13485* / SMAD family member 4* / Mothers against decapentaplegic homolog 4 *ENSGALG0000003941734
SMAD6 / mothers against decapentaplegic homolog 6 / O35182* / O43541* / SMAD family member 6*ENSGALG0000002589825
SMAD7B / Gallus gallus TGF-beta signal pathway antagonist Smad7 (SMAD7B), mRNA. / SMAD7* / O35253* / O15105* / SMAD family member 7*ENSGALG0000002954523
SMAD7* / O15105* / O35253* / SMAD family member 7*ENSGALG0000003716022


Protein motifs (from Interpro)
Interpro ID Name
 IPR001132  SMAD domain, Dwarfin-type
 IPR003619  MAD homology 1, Dwarfin-type
 IPR008984  SMAD/FHA domain superfamily
 IPR013019  MAD homology, MH1
 IPR013790  Dwarfin
 IPR017855  SMAD-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001657 ureteric bud development IEA
 biological_processGO:0002051 osteoblast fate commitment IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007281 germ cell development IEA
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0060048 cardiac muscle contraction IEA
 biological_processGO:0060348 bone development IEA
 biological_processGO:0060395 SMAD protein signal transduction IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0017151 DEAD/H-box RNA helicase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001229 SKI / ski oncogene / P12755* / SKI proto-oncogene*  / reaction / complex
 ENSGALG00000002003 BMPR1A / bone morphogenetic protein receptor type-1A precursor / P36894* / P36895* / Bone morphotic protein receptor type-1A * / bone morphogenetic protein receptor type 1A*  / reaction / complex
 ENSGALG00000009977 SMAD1 / mothers against decapentaplegic homolog 1 / P70340* / Q15797* / SMAD family member 1*  / complex / reaction
 ENSGALG00000017050 SMAD9 / mothers against decapentaplegic homolog 9 / O15198* / Q9JIW5* / SMAD family member 9*  / complex / reaction
 ENSGALG00000012216 BMPR1B / bone morphogenetic protein receptor type-1B precursor / O00238* / P36898* / bone morphogenetic protein receptor type 1B* / Mus musculus bone morphotic protein receptor, type 1B (B...  / complex / reaction
 ENSGALG00000029301 BMP2 / bone morphogenetic protein 2 precursor / P12643* / P21274* / Bone morphotic protein 2 * / bone morphogenetic protein 2*  / reaction / complex
 ENSGALG00000006309 SMAD5 / Q56I99 / Mothers against decapentaplegic homolog 5 / P97454* / Q99717* / SMAD family member 5*  / complex / reaction
 ENSGALG00000006158 ACVR2B / activin receptor type-2B precursor / P27040* / Q13705* / Activin receptor type-2B * / activin A receptor type 2B*  / reaction / complex
 ENSGALG00000015576 ZFYVE16 / zinc finger FYVE-type containing 16 / Q7Z3T8* / Q80U44* / zinc finger, FYVE domain containing 16*  / complex / reaction
 ENSGALG00000012444 ACVR2A / Q90669 / Activin receptor type-2A / P27037* / P27038* / activin A receptor type 2A*  / reaction / complex
 ENSGALG00000008459 BMPR2 / bone morphogenetic protein receptor type 2 / O35607* / Q13873* / Bone morphotic protein receptor type-2 *  / reaction / complex






 

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