ENSGALG00000001229


Gallus gallus

Features
Gene ID: ENSGALG00000001229
  
Biological name :SKI
  
Synonyms : SKI / ski oncogene
  
Possible biological names infered from orthology : P12755 / SKI proto-oncogene
  
Species: Gallus gallus
  
Chr. number: 21
Strand: -1
Band:
Gene start: 1663100
Gene end: 1753291
  
Corresponding Affymetrix probe sets: GgaAffx.816.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000001862
Ensembl peptide - ENSGALP00000057360
NCBI entrez gene - 428181     See in Manteia.
RefSeq - XM_015296939
RefSeq - NM_001039318
RefSeq - XM_015296936
RefSeq - XM_015296938
RefSeq Peptide - NP_001034407
swissprot - E1BSJ7
swissprot - A0A1D5PWM5
Ensembl - ENSGALG00000001229
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 skiaENSDARG00000042151Danio rerio
 skibENSDARG00000008034Danio rerio
 SKIENSG00000157933Homo sapiens
 SkiENSMUSG00000029050Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SKIL / ski-like protein / Q60665* / P12757* / SKI-like* / SKI like proto-oncogene*ENSGALG0000000935636
SKOR1 / SKI family transcriptional corepressor 1 / P84550* / Q8BX46*ENSGALG0000002952118
SKOR2* / A7M7C7* / Q2VWA4* / SKI family transcriptional corepressor 2*ENSGALG0000004554411


Protein motifs (from Interpro)
Interpro ID Name
 IPR003380  SKI/SNO/DAC domain
 IPR009061  Putative DNA-binding domain superfamily
 IPR010919  SAND-like domain superfamily
 IPR014890  c-SKI SMAD4-binding domain
 IPR023216  Transcription regulator SKI/SnoN
 IPR028760  Ski oncogene


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010626 negative regulation of Schwann cell proliferation IEA
 biological_processGO:0014902 myotube differentiation IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0032926 negative regulation of activin receptor signaling pathway IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0060395 SMAD protein signal transduction IEA
 biological_processGO:0070207 protein homotrimerization IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IMP
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IMP
 molecular_functionGO:0043565 sequence-specific DNA binding IMP
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0070491 repressing transcription factor binding IEA


Pathways (from Reactome)
Pathway description
Signaling by BMP
Downregulation of SMAD2/3:SMAD4 transcriptional activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000017050 SMAD9 / mothers against decapentaplegic homolog 9 / O15198* / Q9JIW5* / SMAD family member 9*  / reaction / complex
 ENSGALG00000006309 SMAD5 / Q56I99 / Mothers against decapentaplegic homolog 5 / P97454* / Q99717* / SMAD family member 5*  / reaction / complex
 ENSGALG00000009977 SMAD1 / mothers against decapentaplegic homolog 1 / P70340* / Q15797* / SMAD family member 1*  / reaction / complex
 ENSGALG00000014184 SMAD2* / Q15796* / Q62432* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / reaction / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex
 ENSGALG00000036001 SMAD2Z / SMAD2* / Q62432* / Q15796* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex






 

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