ENSGALG00000037716


Gallus gallus

Features
Gene ID: ENSGALG00000037716
  
Biological name :UBA52
  
Synonyms : UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1
  
Possible biological names infered from orthology : Gm11808 / Gm5239 / P62984 / P62987 / predicted gene 11808
  
Species: Gallus gallus
  
Chr. number: 28
Strand: -1
Band:
Gene start: 3900551
Gene end: 3901583
  
Corresponding Affymetrix probe sets: Gga.569.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000062168
Ensembl peptide - ENSGALP00000053207
NCBI entrez gene - 395958     See in Manteia.
RefSeq - NM_205075
RefSeq Peptide - NP_990406
swissprot - O42388
swissprot - A0A1L1RTM7
Ensembl - ENSGALG00000037716
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uba52ENSDARG00000041435Danio rerio
 UBA52ENSG00000221983Homo sapiens
 Gm5239ENSMUSG00000062742Mus musculus
 P62984ENSMUSG00000068240Mus musculus
 Uba52ENSMUSG00000090137Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR001975  Ribosomal protein L40e
 IPR019954  Ubiquitin conserved site
 IPR019956  Ubiquitin
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0003735 structural constituent of ribosome IEA


Pathways (from Reactome)
Pathway description
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Downregulation of ERBB4 signaling
Spry regulation of FGF signaling
Downregulation of ERBB2:ERBB3 signaling
NOD1/2 Signaling Pathway
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
APC-Cdc20 mediated degradation of Nek2A
SRP-dependent cotranslational protein targeting to membrane
EGFR downregulation
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
TCF dependent signaling in response to WNT
Downstream TCR signaling
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Activated NOTCH1 Transmits Signal to the Nucleus
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
Regulation of PLK1 Activity at G2/M Transition
Stimuli-sensing channels
FCERI mediated NF-kB activation
Regulation of innate immune responses to cytosolic DNA
Glycogen synthesis
Autodegradation of the E3 ubiquitin ligase COP1
Deactivation of the beta-catenin transactivating complex
ABC-family proteins mediated transport
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
AUF1 (hnRNP D0) binds and destabilizes mRNA
Degradation of AXIN
Degradation of DVL
Regulation of FZD by ubiquitination
Pink/Parkin Mediated Mitophagy
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Hedgehog ligand biogenesis
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog on state
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
TNFR2 non-canonical NF-kB pathway
Negative regulation of MAPK pathway
Regulation of necroptotic cell death
MAP3K8 (TPL2)-dependent MAPK1/3 activation
HDR through Homologous Recombination (HRR)
MAPK6/MAPK4 signaling
UCH proteinases
Josephin domain DUBs
Ub-specific processing proteases
Ovarian tumor domain proteases
Metalloprotease DUBs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
Negative regulation of MET activity
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Ubiquitin-dependent degradation of Cyclin D1
Cyclin D associated events in G1
Stabilization of p53
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Downregulation of ERBB2 signaling
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN localization
Regulation of PTEN stability and activity
ER Quality Control Compartment (ERQC)
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Peroxisomal protein import
Regulation of signaling by CBL
Endosomal Sorting Complex Required For Transport (ESCRT)
Iron uptake and transport
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000102 UBE2T / ubiquitin conjugating enzyme E2 T / Q9CQ37* / Q9NPD8*  / reaction / complex
 ENSGALG00000000734 RPA2 / RPA4* / Q13156* / P15927* / replication protein A2* / replication protein A4*  / reaction / complex
 ENSGALG00000001309 SNF8 / SNF8, ESCRT-II complex subunit / Q96H20* / Q9CZ28* / Mus musculus SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) (Snf8), transcript variant 2, mRNA.*  / reaction / complex
 ENSGALG00000001028 RNF43 / ring finger protein 43 / Q5NCP0* / Q68DV7* / E3 ubiquitin-protein ligase RNF43 *  / reaction
 ENSGALG00000001600 DVL1 / dishevelled segment polarity protein 1 / O14640* / P51141* / Segment polarity DVL-1 *  / reaction
 ENSGALG00000001006 TP73 / tumor protein p73 / Trp73* / Q9JJP2* / O15350* / transformation related protein 73*  / reaction
 ENSGALG00000002085 FZR1 / fizzy-related protein homolog / Q9R1K5* / Q9UM11* / fizzy and cell division cycle 20 related 1*  / complex / reaction
 ENSGALG00000002229 FBXW11 / F-box and WD repeat domain containing 11 / Q5SRY7* / Q9UKB1* / F-box/WD repeat-containing protein 11 *  / reaction
 ENSGALG00000002151 PEX12 / peroxisomal biogenesis factor 12 / O00623* / Q8VC48* / Peroxisome assembly protein 12 *  / complex / reaction
 ENSGALG00000001946 RSPO1 / R-spondin-1 precursor / Q2MKA7* / R-spondin 1*  / reaction
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSGALG00000004500 COP1 / COP1, E3 ubiquitin ligase / Q8NHY2* / Q9R1A8*  / reaction / complex
 ENSGALG00000004655 SMURF1 / SMAD specific E3 ubiquitin protein ligase 1 / Q9CUN6* / Q9HCE7* / E3 ubiquitin-protein ligase SMURF1 *  / reaction / complex
 ENSGALG00000003144 TRIM25 / Gallus gallus tripartite motif containing 25 (TRIM25), mRNA. / Q14258* / Q61510* / tripartite motif containing 25* / E3 ubiquitin/ISG15 ligase TRIM25 *  / complex
 ENSGALG00000003085 CDK1 / cyclin-dependent kinase 1 / P06493* / P11440*  / complex / reaction
 ENSGALG00000002836 PEX14 / peroxisomal biogenesis factor 14 / O75381* / Q9R0A0* / Peroxisomal membrane protein PEX14 *  / complex / reaction
 ENSGALG00000004640 MAD2L2 / Q4KWZ6 / Mitotic spindle assembly checkpoint protein MAD2B / Q9D752* / Q9UI95* / mitotic arrest deficient 2 like 2*  / reaction / complex
 ENSGALG00000003072 RPA1 / Q5ZJJ2 / Replication protein A 70 kDa DNA-binding subunit / Q8VEE4* / P27694* / replication protein A1*  / reaction / complex
 ENSGALG00000003720 FANCD2 / Fanconi anemia complementation group D2 / Q80V62* / Q9BXW9* / Fanconi anemia group D2 protein homolog *  / reaction / complex
 ENSGALG00000007971 SUMO2 / Q5ZJM9 / Small ubiquitin-related modifier 2 / SUMO4* / Q6EEV6* / P61957* / P61956* / small ubiquitin-like modifier 2* / small ubiquitin-like modifier 4*  / complex
 ENSGALG00000006392 RNF168 / ring finger protein 168 / Q80XJ2* / Q8IYW5* / E3 ubiquitin-protein ligase RNF168 *  / reaction
 ENSGALG00000007832 PEX13 / peroxisomal biogenesis factor 13 / Q92968* / Q9D0K1* / Peroxisomal membrane protein PEX13 *  / complex / reaction
 ENSGALG00000008559 CUL4B / cullin 4B / A2A432* / Q13620*  / complex / reaction
 ENSGALG00000007095 CUL2 / cullin-2 / Q13617* / Q9D4H8*  / complex / reaction
 ENSGALG00000006357 XPC / XPC complex subunit, DNA damage recognition and repair factor / P51612* / Q01831* / xeroderma pigmentosum, complementation group C*  / reaction / complex
 ENSGALG00000008218 DDB2 / Q5ZJL7 / DNA damage-binding protein 2 / Q92466* / Q99J79* / damage specific DNA binding protein 2*  / complex / reaction
 ENSGALG00000007510 CETN2 / CETN1* / Q9R1K9* / P41209* / Q12798* / P41208* / centrin 2* / centrin 1*  / reaction / complex
 ENSGALG00000005108 CUL3 / cullin 3 / Q13618* / Q9JLV5*  / reaction
 ENSGALG00000008648 UBE2A / ubiquitin conjugating enzyme E2 A / P49459* / Q9Z255*  / complex
 ENSGALG00000007932 TRAF6 / TNF receptor associated factor 6 / P70196* / Q9Y4K3*  / reaction / complex
 ENSGALG00000008435 SUMO1 / Q8QGH2 / Small ubiquitin-related modifier 1 / P63166* / P63165* / small ubiquitin-like modifier 1*  / reaction / complex
 ENSGALG00000008096 SUFU / SUFU negative regulator of hedgehog signaling / Q9UMX1* / Q9Z0P7*  / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000008491 XIAP / BIRC8* / P98170* / Q60989* / Q96P09* / X-linked inhibitor of apoptosis* / baculoviral IAP repeat containing 8*  / reaction
 ENSGALG00000006474 SKP1 / Q5ZKF5 / S-phase kinase-associated protein 1 / Skp1a* / Q9WTX5* / P63208* / AC104109.3* / S-phase kinase-associated protein 1A*  / complex / reaction
 ENSGALG00000014819 JMY / junction mediating and regulatory protein, p53 cofactor / Q8N9B5*  / reaction
 ENSGALG00000016921 UCHL3 / ubiquitin carboxyl-terminal hydrolase isozyme L3 / Uchl4* / Q9JKB1* / P58321* / P15374* / ubiquitin C-terminal hydrolase L3* / ubiquitin carboxyl-terminal esterase L4* / ubiquitin ...  / reaction / complex
 ENSGALG00000014956 POLK / DNA polymerase kappa / Q9QUG2* / Q9UBT6* / polymerase (DNA directed), kappa*  / reaction / complex
 ENSGALG00000016284 TAB3 / TGF-beta activated kinase 1 and MAP3K7 binding protein 3 / Q571K4* / Q8N5C8* / TGF-beta activated kinase 1/MAP3K7 binding protein 3*  / reaction / complex
 ENSGALG00000010001 EGLN3 / egl-9 family hypoxia inducible factor 3 / Q9H6Z9*  / complex / reaction
 ENSGALG00000008407 IRAK2 / interleukin-1 receptor-associated kinase-like 2 / O43187* / Q8CFA1* / interleukin 1 receptor associated kinase 2*  / complex / reaction
 ENSGALG00000012356 TAB2 / TGF-beta activated kinase 1/MAP3K7 binding protein 2 / Q99K90* / Q9NYJ8* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 *  / complex / reaction
 ENSGALG00000015596 MAP3K7 / mitogen-activated protein kinase kinase kinase 7 / O43318* / Q62073*  / complex / reaction
 ENSGALG00000012879 VPS4B / vacuolar protein sorting 4 homolog B / O75351* / P46467* / vacuolar protein sorting 4B*  / reaction
 ENSGALG00000016931 BORA / Q6PGQ7* / Q8BS90* / Protein aurora borealis * / bora, aurora kinase A activator*  / reaction / complex
 ENSGALG00000010005 EPAS1 / endothelial PAS domain protein 1 / P97481* / Q99814* / Endothelial PAS domain-containing protein 1 *  / complex / reaction
 ENSGALG00000015184 TLE4Z1 / transducin like enhancer of split 4-Z 1 / TLE4* / Q62441* / Q04727* / transducin like enhancer of split 4* / Transducin-like enhancer protein 4 *  / reaction
 ENSGALG00000011065 SPRTN / SprT-like N-terminal domain / G3X912* / Q9H040* / SprT-like domain-containing protein Spartan *  / reaction / complex
 ENSGALG00000011442 Q90999 / TGFBR2 / TGF-beta receptor type-2 / Q62312* / P37173* / transforming growth factor beta receptor 2* / transforming growth factor, beta receptor II*  / reaction / complex
 ENSGALG00000009939 SPOP / speckle type BTB/POZ protein / Gm5286* / Gm5773* / Gm9117* / Gm9125* / Tdpoz5* / Gm4778* / Gm4858* / O43791* / P0DMR5* / P0DMR6* / Q6YCH2* / Q6ZWS8* / Q717B2* / Q717B4* / Tdpoz1* / T...  / reaction
 ENSGALG00000021213 UBE2D1 / ubiquitin conjugating enzyme E2 D1 / P51668* / P61080*  / complex
 ENSGALG00000009971 CDC20 / cell division cycle 20 / Q12834* / Q9JJ66* / Cell division cycle *  / complex / reaction
 ENSGALG00000012150 TAB1 / TGF-beta activated kinase 1 (MAP3K7) binding protein 1 / Q15750* / Q8CF89* / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 *  / reaction / complex
 ENSGALG00000006052 WDR48 / Q5F3K4 / WD repeat-containing protein 48 / Q8TAF3* / Q8BH57* / WD repeat domain 48*  / reaction / complex
 ENSGALG00000017159 ATM / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / reaction
 ENSGALG00000010700 RPA3 / replication protein A3 / P35244* / Q9CQ71* / Replication protein A 14 kDa subunit *  / reaction / complex
 ENSGALG00000013874 PEX7 / peroxisomal biogenesis factor 7 / O00628* / P97865* / Peroxisomal targeting signal 2 receptor *  / reaction / complex
 ENSGALG00000011630 GLI2 / GLI family zinc finger 2 / P10070* / Q0VGT2* / Zinc finger protein GLI2 *  / reaction
 ENSGALG00000013810 VTA1 / vesicle trafficking 1 / Q9CR26* / Q9NP79* / vesicle (multivesicular body) trafficking 1*  / reaction
 ENSGALG00000028543 FGFR4 / fibroblast growth factor receptor 4 / P22455*  / reaction / complex
 ENSGALG00000016766 REV1 / DNA repair protein REV1 / Q920Q2* / Q9UBZ9* / REV1, DNA directed polymerase*  / reaction / complex
 ENSGALG00000009901 DYRK2 / Q5ZIU3 / Dual specificity tyrosine-phosphorylation-regulated kinase 2 / Q5U4C9* / Q92630*  / reaction
 ENSGALG00000009966 FRS2 / fibroblast growth factor receptor substrate 2 / Q8C180* / Q8WU20*  / complex / reaction
 ENSGALG00000011286 UBE2E1 / ubiquitin conjugating enzyme E2 E1 / P51965* / P52482*  / complex
 ENSGALG00000014184 SMAD2* / Q15796* / Q62432* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSGALG00000016739 HERC2 / HECT and RLD domain containing E3 ubiquitin protein ligase 2 / O95714* / Q4U2R1* / E3 ubiquitin-protein ligase HERC2 *  / reaction
 ENSGALG00000017186 BIRC2 / BIRC3* / Q62210* / Q13489* / Q13490* / baculoviral IAP repeat containing 2* / baculoviral IAP repeat containing 3* / Baculoviral IAP repeat-containing protein 2 *  / reaction / complex
 ENSGALG00000010957 USP1 / ubiquitin carboxyl-terminal hydrolase 1 / O94782* / Q8BJQ2* / ubiquitin specific peptidase 1*  / reaction / complex
 ENSGALG00000009837 DTL / Q5ZJW8 / Denticleless protein homolog / Q3TLR7* / Q9NZJ0* / denticleless E3 ubiquitin protein ligase homolog*  / reaction
 ENSGALG00000009942 MDM2 / MDM2 proto-oncogene / P23804* / Q00987* / E3 ubiquitin-protein ligase Mdm2 *  / reaction
 ENSGALG00000017211 MRE11 / double-strand break repair protein MRE11 / Mre11a* / Q61216* / P49959* / MRE11 homolog, double strand break repair nuclease*  / reaction
 ENSGALG00000013626 GMNN / geminin / O75496* / O88513* / geminin, DNA replication inhibitor*  / reaction / complex
 ENSGALG00000013861 TNFAIP3 / TNF alpha induced protein 3 / P21580* / Q60769* / tumor necrosis factor, alpha-induced protein 3*  / reaction
 ENSGALG00000009681 BUB3 / BUB3, mitotic checkpoint protein / O43684* / Q9WVA3* / Mitotic checkpoint protein BUB3 *  / reaction / complex
 ENSGALG00000016906 SPRY2 / protein sprouty homolog 2 / O43597* / Q9QXV8* / sprouty RTK signaling antagonist 2*  / reaction / complex
 ENSGALG00000012827 RIPK1 / receptor interacting serine/threonine kinase 1 / Q13546* / Q60855* / Receptor-interacting serine/threonine-protein kinase 1 *  / complex / reaction
 ENSGALG00000015705 NSD2 / nuclear receptor binding SET domain protein 2 / O96028* / Q8BVE8* / Histone-lysine N-methyltransferase NSD2 *  / reaction
 ENSGALG00000010163 LGR5 / leucine rich repeat containing G protein-coupled receptor 5 / O75473* / Q9Z1P4*  / reaction
 ENSGALG00000015033 REV3L / REV3 like, DNA directed polymerase zeta catalytic subunit / O60673* / Q61493* / DNA polymerase zeta catalytic subunit *  / reaction / complex
 ENSGALG00000012575 TLE1 / transducin like enhancer of split 1 / Q04724* / Q62440* / Transducin-like enhancer protein 1 *  / reaction
 ENSGALG00000011762 UBA6 / ubiquitin like modifier activating enzyme 6 / A0AVT1* / Q8C7R4*  / complex
 ENSGALG00000013160 CHMP5 / charged multivesicular body protein 5 / Q9D7S9* / Q9NZZ3*  / reaction
 ENSGALG00000010581 SEL1L / SEL1L ERAD E3 ligase adaptor subunit / Q9UBV2* / Q9Z2G6* / sel-1 suppressor of lin-12-like (C. elegans)*  / reaction
 ENSGALG00000011993 RBX1 / ring-box 1 / P62877* / P62878* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / reaction / complex
 ENSGALG00000028133 UBE2V2 / Q5F3Z3 / Ubiquitin-conjugating enzyme E2 variant 2 / Q9D2M8* / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex / reaction
 ENSGALG00000028664 CKS1B / CDC28 protein kinase regulatory subunit 1B / P61024* / P61025* / Cks1brt* / CDC28 protein kinase 1b, retrogene* / Cyclin-dependent kinases regulatory subunit 1 *  / reaction / complex
 ENSGALG00000041844 DERL2 / derlin 2 / Q8BNI4* / Q9GZP9*  / reaction
 ENSGALG00000029292 PCNA / Q9DEA3 / Proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex / reaction
 ENSGALG00000026850 TICAM1 / TIR domain-containing adapter molecule 1 / Q80UF7* / Q8IUC6* / toll like receptor adaptor molecule 1*  / reaction / complex
 ENSGALG00000012289 SHPRH / SNF2 histone linker PHD RING helicase / Q149N8* / Q7TPQ3* / E3 ubiquitin-protein ligase SHPRH *  / complex / reaction
 ENSGALG00000033974 HGF / hepatocyte growth factor / P14210* / Q08048* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / reaction
 ENSGALG00000032664 UBE2B / ubiquitin conjugating enzyme E2 B / P63146* / P63147*  / reaction / complex
 ENSGALG00000036892 BUB1B / BUB1 mitotic checkpoint serine/threonine kinase B / O60566* / Q9Z1S0* / Mitotic checkpoint serine/threonine-protein kinase BUB1 beta *  / reaction / complex
 ENSGALG00000028009 VHL* / VHLL* / P40338* / Q6RSH7* / P40337* / VHL like* / von Hippel-Lindau tumor suppressor*  / reaction / complex
 ENSGALG00000029402 AXIN1 / O15169*  / reaction
 ENSGALG00000030063 MALT1 / MALT1 paracaspase / Q2TBA3* / Q9UDY8* / Mucosa-associated lymphoid tissue lymphoma translocation *  / reaction
 ENSGALG00000006794 RAD50* / Q92878* / AC116366.3* / RAD50 double strand break repair protein*  / reaction
 ENSGALG00000012124 PELI2 / pellino E3 ubiquitin protein ligase family member 2 / Q9HAT8*  / complex
 ENSGALG00000045705 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / reaction
 ENSGALG00000036001 SMAD2Z / SMAD2* / Q62432* / Q15796* / SMAD family member 2* / Mothers against decapentaplegic homolog 2 *  / complex / reaction
 ENSGALG00000035287 STAM / signal transducing adaptor molecule / P70297* / Q92783* / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1*  / complex
 ENSGALG00000038541 VPS37C / vacuolar protein sorting-associated protein 37C / Q8R105* / A5D8V6* / VPS37C, ESCRT-I subunit* / vacuolar protein sorting 37C*  / complex / reaction
 ENSGALG00000014525 USP5 / ubiquitin specific peptidase 5 / P45974* / P56399* / ubiquitin specific peptidase 5 (isopeptidase T)*  / complex
 ENSGALG00000001229 SKI / ski oncogene / P12755* / SKI proto-oncogene*  / complex
 ENSGALG00000010317 POLH / DNA polymerase eta / Q9JJN0* / Q9Y253*  / complex / reaction
 ENSGALG00000016590 TLR7 / toll-like receptor 7 / P58681* / Q9NYK1*  / reaction
 ENSGALG00000015422 NRG1 / pro-neuregulin-1, membrane-bound isoform / Q02297* / neuregulin 1*  / reaction / complex
 ENSGALG00000017068 KL / klotho / O35082* / Q9UEF7* / Klotho Klotho peptide*  / reaction / complex
 ENSGALG00000033641 NRG2 / neuregulin 2 / O14511*  / reaction / complex
 ENSGALG00000040474 ITCH / itchy E3 ubiquitin protein ligase / Q8C863* / Q96J02* / E3 ubiquitin-protein ligase Itchy *  / complex / reaction
 ENSGALG00000041226 RRAGB* / RRAGA* / Q7L523* / Q80X95* / Q5VZM2* / Q6NTA4* / Ras related GTP binding A* / Ras related GTP binding B* / Ras-related GTP-binding protein A * / Ras-related GTP-binding protein B *  / complex / reaction
 ENSGALG00000039786 FGFR1 / fibroblast growth factor receptor 1 precursor / P11362* / P16092* / fibroblast growth factor receptor 1*  / complex / reaction
 ENSGALG00000013646 VPS37A / VPS37A, ESCRT-I subunit / Q8CHS8* / Q8NEZ2* / vacuolar protein sorting 37A*  / complex / reaction
 ENSGALG00000040794 CCNE2 / cyclin E2 / O96020* / Q9Z238* / G1/S-specific cyclin-E2 *  / reaction / complex
 ENSGALG00000010543 EPS15 / epidermal growth factor receptor substrate 15 / P42566* / P42567* / epidermal growth factor receptor pathway substrate 15*  / complex / reaction
 ENSGALG00000027791 FGF23 / fibroblast growth factor 23 / Q9EPC2* / Q9GZV9*  / complex / reaction
 ENSGALG00000005947 MYD88 / A5HNF6 / Myeloid differentiation primary response protein MyD88 / Q99836* / P22366* / myeloid differentiation primary response 88* / myeloid differentiation primary response gene 88*  / reaction
 ENSGALG00000035919 EPN2 / epsin-2 / O95208* / Q8CHU3*  / reaction / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction / complex / -
 ENSGALG00000026449 H2AFX* / P16104* / P27661* / Histone H2AX * / H2A histone family member X*  / reaction
 ENSGALG00000006312 TSG101 / tumor susceptibility 101 / Q61187* / Q99816* / tumor susceptibility gene 101*  / reaction / complex
 ENSGALG00000043535 RIPK2 / receptor-interacting serine/threonine-protein kinase 2 / O43353* / P58801* / receptor interacting serine/threonine kinase 2* / receptor (TNFRSF)-interacting serine-threonine kinase 2*  / complex
 ENSGALG00000000950 MVB12B / multivesicular body subunit 12B / Q6KAU4* / Q9H7P6*  / reaction / complex
 ENSGALG00000043164 TNKS / tankyrase-1 / O95271* / Q6PFX9* / tankyrase* / tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase*  / reaction
 ENSGALG00000009586 IRAK4 / interleukin-1 receptor-associated kinase 4 / Q8R4K2* / Q9NWZ3*  / complex / reaction
 ENSGALG00000026820 RNF146 / ring finger protein 146 / Q9CZW6* / Q9NTX7*  / reaction
 ENSGALG00000001976 TRIM33 / tripartite motif containing 33 / Q9UPN9*  / reaction
 ENSGALG00000042333 DDB1 / Q805F9 / DNA damage-binding protein 1 / Q16531* / Q3U1J4* / damage specific DNA binding protein 1*  / reaction / complex
 ENSGALG00000003743 VPS37B / VPS37B, ESCRT-I subunit / Q8R0J7* / Q9H9H4* / vacuolar protein sorting 37B*  / complex / reaction
 ENSGALG00000041795 WWP1 / WW domain containing E3 ubiquitin protein ligase 1 / Q8BZZ3* / Q9H0M0*  / complex / reaction
 ENSGALG00000007224 HGS / hepatocyte growth factor-regulated tyrosine kinase substrate / O14964* / hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2 *  / complex
 ENSGALG00000014261 UCHL1 / ubiquitin C-terminal hydrolase L1 / P09936* / Q9R0P9* / ubiquitin carboxy-terminal hydrolase L1*  / complex
 ENSGALG00000009228 PARP1 / poly / P09874* / poly(ADP-ribose) polymerase 1* / poly (ADP-ribose) polymerase family, member 1*  / complex / reaction
 ENSGALG00000015708 FGFR3 / fibroblast growth factor receptor 3 / P22607* / Mus musculus fibroblast growth factor receptor 3 (Fgfr3), transcript variant 6, mRNA.*  / reaction / complex
 ENSGALG00000014732 ERCC8 / ERCC excision repair 8, CSA ubiquitin ligase complex subunit / Q13216* / Q8CFD5* / DNA excision repair protein ERCC-8 *  / complex / reaction
 ENSGALG00000014773 ERBIN / erbb2 interacting protein / Q80TH2* / Q96RT1*  / reaction
 ENSGALG00000033179 TGFBR1 / transforming growth factor beta receptor 1 / P36897* / Q64729* / transforming growth factor, beta receptor I*  / complex / reaction
 ENSGALG00000023335 RCHY1 / ring finger and CHY zinc finger domain containing 1 / Q96PM5* / Q9CR50*  / reaction
 ENSGALG00000032819 RNF41 / ring finger protein 41 / Q8BH75* / Q9H4P4* / E3 ubiquitin-protein ligase NRDP1 *  / reaction / complex
 ENSGALG00000000518 KLHL12 / kelch like family member 12 / Q53G59* / Q8BZM0* / Kelch-like protein 12 *  / reaction
 ENSGALG00000038089 EGFR / epidermal growth factor receptor / P00533* / Q01279*  / complex / reaction
 ENSGALG00000010623 ORC1 / origin recognition complex subunit 1 / Q13415* / Q9Z1N2*  / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / - / complex / reaction
 ENSGALG00000008015 UBE2V1 / ubiquitin-conjugating enzyme E2 variant 1 / Q13404* / ubiquitin conjugating enzyme E2 V1*  / complex / reaction
 ENSGALG00000032701 LY96 / lymphocyte antigen 96 / Q9JHF9* / Q9Y6Y9*  / complex / reaction
 ENSGALG00000023256 RNF8 / ring finger protein 8 / O76064* / Q8VC56* / Gm28043* / E3 ubiquitin-protein ligase RNF8 *  / reaction
 ENSGALG00000008837 PELI1 / E3 ubiquitin-protein ligase pellino homolog 1 / Q8C669* / Q96FA3* / pellino 1* / pellino E3 ubiquitin protein ligase 1*  / complex
 ENSGALG00000036941 CUL1 / cullin 1 / Q13616* / Q9WTX6* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / reaction / complex
 ENSGALG00000015666 TNIP2 / TNFAIP3 interacting protein 2 / Q8NFZ5* / Q99JG7*  / reaction
 ENSGALG00000042657 WNT3A / Q2LMP1 / Protein Wnt-3a / P56704* / P27467* / Wnt family member 3A* / wingless-type MMTV integration site family, member 3A*  / reaction
 ENSGALG00000042491 P62801 / Histone H4   / reaction
 ENSGALG00000040424 SCNN1A / amiloride-sensitive sodium channel subunit alpha / P37088* / sodium channel, nonvoltage-gated 1 alpha* / sodium channel epithelial 1 alpha subunit*  / reaction
 ENSGALG00000004796 CDC42 / Q90694 / Cell division control protein 42 homolog / P60766* / P60953* / cell division cycle 42* / Cell division control *  / reaction / complex
 ENSGALG00000004347 NEDD4 / neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase / P46934* / P46935* / neural precursor cell expressed, developmentally down-regulated 4*  / complex / reaction
 ENSGALG00000009410 PEX1 / peroxisomal biogenesis factor 1 / O43933* / Q5BL07* / Peroxisome biosis factor 1 *  / complex / reaction
 ENSGALG00000032986 CFTR / cystic fibrosis transmembrane conductance regulator / P13569* / P26361*  / reaction / complex
 ENSGALG00000006505 ZFAND6 / zinc finger AN1-type containing 6 / Q6FIF0* / Q9DCH6* / zinc finger, AN1-type domain 6*  / complex / reaction
 ENSGALG00000034413 PIAS4 / protein inhibitor of activated STAT 4 / Q8N2W9* / Q9JM05*  / reaction
 ENSGALG00000031529 ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *  / complex / reaction
 ENSGALG00000003126 ERBB4 / receptor tyrosine-protein kinase erbB-4 / Q15303* / Q61527* / erb-b2 receptor tyrosine kinase 4* / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain*  / complex / reaction
 ENSGALG00000007768 AURKA / aurora kinase A / O14965* / P97477*  / reaction
 ENSGALG00000042067 SPRY1 / sprouty RTK signaling antagonist 1 / O43609* / Q9QXV9*  / reaction / complex
 ENSGALG00000039140 CD14 / monocyte differentiation antigen CD14 precursor / P10810* / P08571* / CD14 molecule* / Monocyte differentiation antigen CD14 *  / reaction / complex
 ENSGALG00000022980 CDKN1B / cyclin dependent kinase inhibitor 1B / P46414* / P46527*  / reaction / complex
 ENSGALG00000036883 MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*  / reaction
 ENSGALG00000014614 TNKS2 / tankyrase-2 / Q3UES3* / Q9H2K2*  / reaction
 ENSGALG00000006254 ERCC6 / ERCC excision repair 6, chromatin remodeling factor / P0DP91* / Q03468* / Q8N328*  / complex / reaction
 ENSGALG00000009495 FGFR2 / P18461 / Fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *  / reaction / complex
 ENSGALG00000028935 BCL10 / B cell CLL/lymphoma 10 / O95999* / Q9Z0H7* / B-cell lymphoma/leukemia 10 *  / reaction / complex
 ENSGALG00000008414 DVL3 / dishevelled segment polarity protein 3 / Q61062* / Q92997* / Segment polarity DVL-3 *  / reaction
 ENSGALG00000040276 RUNX2 / runt related transcription factor 2 / Q08775* / Q13950*  / reaction
 ENSGALG00000036807 NOD1 / Gallus gallus nucleotide binding oligomerization domain containing 1 (NOD1), mRNA. / Q8BHB0* / Q9Y239* / nucleotide binding oligomerization domain containing 1* / Nucleotide-binding ...  / complex
 ENSGALG00000004398 CARD11 / caspase recruitment domain family member 11 / Q8CIS0* / Q9BXL7* / Caspase recruitment domain-containing protein 11 *  / reaction
 ENSGALG00000006270 SCNN1G / sodium channel epithelial 1 gamma subunit / P51170* / Q9WU39* / Amiloride-sensitive sodium channel subunit gamma *  / reaction
 ENSGALG00000003566 SMURF2 / SMAD specific E3 ubiquitin protein ligase 2 / A2A5Z6* / Q9HAU4* / E3 ubiquitin-protein ligase SMURF2 *  / reaction
 ENSGALG00000006418 PDPK1 / 3-phosphoinositide dependent protein kinase 1 / O15530* / Q9Z2A0*  / reaction
 ENSGALG00000017242 FZD4 / Q9IA05 / Frizzled-4 / Q61088* / Q9ULV1* / frizzled class receptor 4*  / reaction
 ENSGALG00000034262 VPS25 / vacuolar protein sorting 25 homolog / Q9BRG1* / Q9CQ80* / vacuolar protein sorting 25*  / complex / reaction
 ENSGALG00000007356 MAP3K8 / mitogen-activated protein kinase kinase kinase 8 / P41279* / Q07174*  / reaction
 ENSGALG00000038128 UBE2D2 / ubiquitin conjugating enzyme E2 D2 / P62838* / P62837* / Ube2d2a* / ubiquitin-conjugating enzyme E2D 2A*  / complex
 ENSGALG00000031503 LRP6 / LDL receptor related protein 6 / O75581*  / reaction
 ENSGALG00000038469 CDC25A / cell division cycle 25A / P30304* / P48964* / M-phase inducer phosphatase 1 *  / complex
 ENSGALG00000041432 STUB1 / Q5ZHY5 / STIP1 homology and U box-containing protein 1 / Q9UNE7* / Q9WUD1*  / reaction
 ENSGALG00000012304 NFKB1 / Q04861 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / P25799* / nuclear factor kappa B subunit 1*  / reaction / complex
 ENSGALG00000028709 RNF144A / ring finger protein 144A / P50876* / Q925F3* / E3 ubiquitin-protein ligase RNF144A *  / complex
 ENSGALG00000007307 USP7 / ubiquitin specific peptidase 7 / Q93009*  / reaction
 ENSGALG00000028822 RNF152 / E1C2W7 / E3 ubiquitin-protein ligase RNF152 / Q8BG47* / Q8N8N0* / ring finger protein 152*  / complex / reaction
 ENSGALG00000028376 FGF19 / fibroblast growth factor 19 / Fgf15* / O95750* / O35622* / Fibroblast growth factor 15 *  / reaction / complex
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSGALG00000030030 RSPO2 / R-spondin-2 precursor / Q8BFU0* / Q6UXX9* / R-spondin 2* / Mus musculus R-spondin 2 (Rspo2), transcript variant 1, mRNA.*  / reaction
 ENSGALG00000040266 GLI3 / GLI family zinc finger 3 / P10071* / Q61602* / Transcriptional activator GLI3 Transcriptional repressor GLI3R*  / reaction
 ENSGALG00000030943 KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*  / reaction
 ENSGALG00000005894 USP8 / ubiquitin specific peptidase 8 / P40818* / Q80U87*  / complex / reaction
 ENSGALG00000040834 LGR4 / leucine rich repeat containing G protein-coupled receptor 4 / A2ARI4* / Q9BXB1*  / reaction
 ENSGALG00000034426 TRIM32 / tripartite motif containing 32 / Q13049* / Q8CH72*  / reaction
 ENSGALG00000041129 TMEM173 / stimulator of interferon genes protein / Q86WV6* / Q3TBT3* / transmembrane protein 173* / Stimulator of interferons protein *  / reaction
 ENSGALG00000035752 PEX2 / peroxisomal biogenesis factor 2 / P28328*  / reaction / complex






 

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