ENSGALG00000001006


Gallus gallus

Features
Gene ID: ENSGALG00000001006
  
Biological name :TP73
  
Synonyms : TP73 / tumor protein p73
  
Possible biological names infered from orthology : O15350 / Q9JJP2 / transformation related protein 73 / Trp73
  
Species: Gallus gallus
  
Chr. number: 21
Strand: -1
Band:
Gene start: 929105
Gene end: 957410
  
Corresponding Affymetrix probe sets: GgaAffx.649.1.S1_at (Chicken Array)   GgaAffx.649.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000001485
NCBI entrez gene - 419382     See in Manteia.
RefSeq - XM_004947367
RefSeq - XM_417545
RefSeq - XM_004947368
RefSeq - XM_015297092
swissprot - F1P1U2
Ensembl - ENSGALG00000001006
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tp73ENSDARG00000017953Danio rerio
 TP73ENSG00000078900Homo sapiens
 Trp73ENSMUSG00000029026Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TP63 / tumor protein 63 / Trp63* / O88898* / Q9H3D4* / tumor protein p63* / transformation related protein 63*ENSGALG0000000732452


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR002117  p53 tumour suppressor family
 IPR008967  p53-like transcription factor, DNA-binding
 IPR010991  p53, tetramerisation domain
 IPR011615  p53, DNA-binding domain
 IPR012346  p53/RUNT-type transcription factor, DNA-binding domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR032646  Tumour protein p73


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IBA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IEA
 biological_processGO:0010165 response to X-ray IBA
 biological_processGO:0010332 response to gamma radiation IBA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0031571 mitotic G1 DNA damage checkpoint IBA
 biological_processGO:0034644 cellular response to UV IBA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:0043508 negative regulation of JUN kinase activity IBA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IBA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051262 protein tetramerization IEA
 biological_processGO:0060044 negative regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0071158 positive regulation of cell cycle arrest IEA
 cellular_componentGO:0000785 chromatin IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IBA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003684 damaged DNA binding IBA
 molecular_functionGO:0003690 double-stranded DNA binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0097371 MDM2/MDM4 family protein binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Association with Co-factors
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000001006 TP73 / tumor protein p73 / Trp73* / Q9JJP2* / O15350* / transformation related protein 73*  / complex
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000011548 PPP1R13B / protein phosphatase 1 regulatory subunit 13B / Q62415* / Q96KQ4* / protein phosphatase 1, regulatory (inhibitor) subunit 13B*  / reaction / complex






 

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