ENSDARG00000017953


Danio rerio

Features
Gene ID: ENSDARG00000017953
  
Biological name :tp73
  
Synonyms : tp73 / tumor protein p73
  
Possible biological names infered from orthology : O15350 / Q9JJP2 / transformation related protein 73 / Trp73
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 48848200
Gene end: 48935476
  
Corresponding Affymetrix probe sets: Dr.24319.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000074096
Ensembl peptide - ENSDARP00000109684
Ensembl peptide - ENSDARP00000109674
NCBI entrez gene - 368221     See in Manteia.
RefSeq - XM_005167294
RefSeq - XM_009304271
swissprot - B0S577
swissprot - B0S576
ZFIN ID - ZDB-GENE-030814-2
Ensembl - ENSDARG00000017953
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TP73ENSGALG00000001006Gallus gallus
 TP73ENSG00000078900Homo sapiens
 Trp73ENSMUSG00000029026Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tp63 / tumor protein p63 / Trp63* / Q9H3D4* / O88898* / transformation related protein 63*ENSDARG0000004435648
tp53 / P79734 / tumor protein p53 / Trp53* / P04637* / P02340* / transformation related protein 53*ENSDARG0000003555925


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR002117  p53 tumour suppressor family
 IPR008967  p53-like transcription factor, DNA-binding
 IPR010991  p53, tetramerisation domain
 IPR011615  p53, DNA-binding domain
 IPR012346  p53/RUNT-type transcription factor, DNA-binding domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR032646  Tumour protein p73


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IBA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0010165 response to X-ray IBA
 biological_processGO:0010332 response to gamma radiation IBA
 biological_processGO:0031571 mitotic G1 DNA damage checkpoint IBA
 biological_processGO:0034644 cellular response to UV IBA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
 biological_processGO:0043508 negative regulation of JUN kinase activity IBA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0051262 protein tetramerization IEA
 cellular_componentGO:0000785 chromatin IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IBA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0002039 p53 binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003684 damaged DNA binding IBA
 molecular_functionGO:0003690 double-stranded DNA binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Association with Co-factors
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain malformed , abnormal
brain decreased size , abnormal
Show

 ZFA:0000048 olfactory placode olfactory placode morphology , abnormal
Show

 ZFA:0000079 telencephalon telencephalon morphology , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000170 basibranchial basibranchial decreased size , abnormal
basibranchial undulate , abnormal
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 ZFA:0000217 inner ear inner ear decreased size , abnormal
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 ZFA:0001094 whole organism whole organism edematous , abnormal
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 ZFA:0001114 head head morphology , abnormal
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 ZFA:0001216 splanchnocranium splanchnocranium morphology , abnormal
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 ZFA:0001306 pharyngeal arch pharyngeal arch malformed , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage mislocalised posteriorly , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage displaced , abnormal
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 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage mislocalised posteriorly , abnormal
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 ZFA:0001458 cranial cartilage cranial cartilage shape , abnormal
cranial cartilage malformed , abnormal
Show

 ZFA:0001510 basihyal cartilage basihyal cartilage decreased size , abnormal
basihyal cartilage undulate , abnormal
Show

 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage decreased size , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000009136 tp53bp2a / tumor protein p53 binding protein, 2a / Q13625* / TP53BP2* / Trp53bp2* / tumor protein p53 binding protein 2* / transformation related protein 53 binding protein 2*  / complex / reaction
 ENSDARG00000009142 ppp1r13bb / protein phosphatase 1, regulatory subunit 13Bb / Q96KQ4* / Q62415* / PPP1R13B* / protein phosphatase 1 regulatory subunit 13B* / protein phosphatase 1, regulatory (inhibitor) subunit 13B*  / reaction / complex
 ENSDARG00000004377 ppp1r13ba / protein phosphatase 1, regulatory subunit 13Ba / Q96KQ4* / Q62415* / PPP1R13B* / protein phosphatase 1 regulatory subunit 13B* / protein phosphatase 1, regulatory (inhibitor) subunit 13B*  / complex / reaction
 ENSDARG00000017953 tp73 / tumor protein p73 / Trp73* / Q9JJP2* / O15350* / transformation related protein 73*  / complex
 ENSDARG00000068401 yap1 / Q1L8J7 / Yes-associated protein 1 / P46937* / P46938*  / reaction / complex
 ENSDARG00000054858 tp53bp2b / tumor protein p53 binding protein, 2b / Q13625* / TP53BP2* / Trp53bp2* / tumor protein p53 binding protein 2* / transformation related protein 53 binding protein 2*  / complex / reaction
 ENSDARG00000013777 ppp1r13l / protein phosphatase 1, regulatory subunit 13 like / Q5I1X5* / Q8WUF5* / protein phosphatase 1, regulatory (inhibitor) subunit 13 like*  / reaction / complex






 

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