ENSDARG00000068401


Danio rerio

Features
Gene ID: ENSDARG00000068401
  
Biological name :yap1
  
Synonyms : Q1L8J7 / yap1 / Yes-associated protein 1
  
Possible biological names infered from orthology : P46937 / P46938
  
Species: Danio rerio
  
Chr. number: 18
Strand: -1
Band:
Gene start: 37283765
Gene end: 37355666
  
Corresponding Affymetrix probe sets: Dr.12698.1.S1_at (Zebrafish Array)   Dr.2355.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000089684
NCBI entrez gene - 561411     See in Manteia.
RefSeq - NM_001139480
RefSeq Peptide - NP_001132952
swissprot - Q1L8J7
ZFIN ID - ZDB-GENE-030131-9710
Ensembl - ENSDARG00000068401
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 YAP1ENSGALG00000038154Gallus gallus
 YAP1ENSG00000137693Homo sapiens
 Yap1ENSMUSG00000053110Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
wwtr1 / WW domain containing transcription regulator 1 / Q9EPK5* / Q9GZV5*ENSDARG0000006771941


Protein motifs (from Interpro)
Interpro ID Name
 IPR001202  WW domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003406 retinal pigment epithelium development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0009950 dorsal/ventral axis specification IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0039022 pronephric duct development IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0046620 regulation of organ growth IMP
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0048916 posterior lateral line development IMP
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0060914 heart formation IMP
 biological_processGO:1905480 positive regulation of glutamate-ammonia ligase activity IMP
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Nuclear signaling by ERBB4
Signaling by Hippo
YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX3 regulates YAP1-mediated transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
brain apoptotic , abnormal
brain hydrocephalic , abnormal
Show

 ZFA:0000014 dorsal aorta dorsal aorta endothelial cell absent , abnormal
Show

 ZFA:0000017 endoderm endoderm cellular quality , abnormal
endoderm antero-medial region decreased object quality , abnormal
endoderm anterior region apoptotic , abnormal
endoderm apoptotic process increased occurrence , abnormal
Show

 ZFA:0000029 hindbrain hindbrain endothelial cell absent , abnormal
Show

 ZFA:0000035 lens lens morphology , abnormal
Show

 ZFA:0000046 retinal neural layer retinal neural layer malformed , abnormal
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 ZFA:0000050 optic vesicle optic vesicle apoptotic , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye closure incomplete , abnormal
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 ZFA:0000114 heart heart malformed , abnormal
heart split bilaterally , abnormal
heart edematous , abnormal
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 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium absent , abnormal
retinal pigmented epithelium malformed , abnormal
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 ZFA:0000150 pronephric duct pronephric duct cilium decreased length , abnormal
pronephric duct establishment or maintenance of cell polarity decreased process quality , abnormal
pronephric duct multi-ciliated epithelial cell disorganized , abnormal
pronephric duct single ciliated epithelial cell decreased amount , abnormal
pronephric duct broken , abnormal
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 ZFA:0000151 pronephros pronephros cystic , abnormal
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 ZFA:0000155 somite somite U-shaped , abnormal
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 ZFA:0000360 heart tube heart tube split bilaterally , abnormal
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 ZFA:0000477 posterior cardinal vein posterior cardinal vein endothelial cell absent , abnormal
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 ZFA:0001054 lateral dorsal aorta lateral dorsal aorta angiogenic sprout increased amount , abnormal
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 ZFA:0001058 caudal fin caudal fin aplastic , abnormal
caudal fin apoptotic process increased process quality , abnormal
caudal fin curved , abnormal
caudal fin decreased length , abnormal
Show

 ZFA:0001094 whole organism whole organism has extra parts of type posterior pancreatic bud , abnormal
whole organism morphology , abnormal
whole organism curved , abnormal
Show

 ZFA:0001104 pharyngeal endoderm pharyngeal endoderm mislocalised laterally , abnormal
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 ZFA:0001114 head head decreased size , abnormal
head apoptotic process increased process quality , abnormal
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 ZFA:0001115 trunk trunk decreased size , abnormal
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 ZFA:0001157 posterior lateral line primordium posterior lateral line primordium has fewer parts of type posterior lateral line primordium cell, abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased length , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel endothelial cell absent , abnormal
intersegmental vessel angiogenic sprout increased amount , abnormal
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 ZFA:0001370 posterior pancreatic bud posterior pancreatic bud decreased size , abnormal
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 ZFA:0001390 pancreatic bud pancreatic bud decreased size , abnormal
pancreatic bud lacks parts or has fewer parts of type cell , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage mislocalised posteriorly , abnormal
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 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage morphology , abnormal
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 ZFA:0001558 pronephric tubule pronephric tubule increased diameter , abnormal
pronephric tubule proximal region dilated , abnormal
pronephric tubule distal region dilated , abnormal
pronephric tubule ciliary basal body mislocalised , abnormal
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 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 morphology , abnormal
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 ZFA:0001620 pronephric proximal convoluted tubule pronephric proximal convoluted tubule morphology , abnormal
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 ZFA:0001623 posterior pronephric duct posterior pronephric duct morphology , abnormal
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 ZFA:0005021 cerebellar central artery cerebellar central artery constricted , abnormal
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 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel endothelial cell absent , abnormal
dorsal longitudinal anastomotic vessel morphology , abnormal
dorsal longitudinal anastomotic vessel constricted , abnormal
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 ZFA:0005242 multi-ciliated epithelial cell multi-ciliated epithelial cell cilium disorganized , abnormal
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 ZFA:0005249 vasculature vasculature hemorrhagic , abnormal
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 ZFA:0005490 myocardial precursor myocardial precursor mislocalised laterally , abnormal
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 ZFA:0005781 cloaca cloaca morphology , abnormal
cloaca atretic , abnormal
cloaca disorganized , abnormal
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 ZFA:0009003 cranial neural crest cell cranial neural crest cell mislocalised , abnormal
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 ZFA:0009127 photoreceptor cell photoreceptor cell photoreceptor outer segment absent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003751 lats1 / large tumor suppressor kinase 1 / O95835* / Q8BYR2* / Serine/threonine-protein kinase LATS1 *  / reaction
 ENSDARG00000019442 AMOTL1 / angiomotin like 1 / Q8IY63*  / complex / reaction
 ENSDARG00000052826 runx3 / runt-related transcription factor 3 / Q13761* / Q64131*  / reaction / complex
 ENSDARG00000061923 A1YB07 / amotl2a / angiomotin like 2a / AMOTL2* / Q8K371* / Q9Y2J4* / angiomotin like 2* / Angiomotin-like protein 2 *  / reaction / complex
 ENSDARG00000017953 tp73 / tumor protein p73 / Trp73* / Q9JJP2* / O15350* / transformation related protein 73*  / reaction / complex
 ENSDARG00000013078 ywhaba / Q5PRD0 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a / YWHAB* / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activat...  / reaction / complex
 ENSDARG00000078864 lats2 / large tumor suppressor kinase 2 / Q7TSJ6* / Q9NRM7* / Serine/threonine-protein kinase LATS2 *  / reaction
 ENSDARG00000078335 amot / angiomotin / Q4VCS5*  / reaction / complex
 ENSDARG00000087646 runx1 / runt-related transcription factor 1 / Q01196*  / complex / reaction
 ENSDARG00000061948 amotl2b / angiomotin like 2b / AMOTL2* / Q8K371* / Q9Y2J4* / angiomotin like 2* / Angiomotin-like protein 2 *  / complex / reaction
 ENSDARG00000035187 abl1 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / P00520* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / reaction






 

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