ENSDARG00000003751


Danio rerio

Features
Gene ID: ENSDARG00000003751
  
Biological name :lats1
  
Synonyms : large tumor suppressor kinase 1 / lats1
  
Possible biological names infered from orthology : O95835 / Q8BYR2 / Serine/threonine-protein kinase LATS1
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 1240461
Gene end: 1268869
  
Corresponding Affymetrix probe sets: Dr.9238.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000157243
Ensembl peptide - ENSDARP00000027561
Ensembl peptide - ENSDARP00000103309
NCBI entrez gene - 553164     See in Manteia.
RefSeq - NM_001020510
RefSeq - XM_005160312
RefSeq - XM_021468417
RefSeq Peptide - NP_001018346
swissprot - Q5RIL6
swissprot - A9JTE1
ZFIN ID - ZDB-GENE-050523-2
Ensembl - ENSDARG00000003751
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LATS1ENSGALG00000012386Gallus gallus
 LATS1ENSG00000131023Homo sapiens
 Lats1ENSMUSG00000040021Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lats2 / large tumor suppressor kinase 2 / Q7TSJ6* / Q9NRM7* / Serine/threonine-protein kinase LATS2 *ENSDARG0000007886447
stk38l / serine/threonine kinase 38 like / Q7TSE6* / Q9Y2H1* / Mus musculus serine/threonine kinase 38 like (Stk38l), transcript variant 2, mRNA.*ENSDARG0000004548218
stk38b / serine/threonine kinase 38b / STK38* / Q15208* / Q91VJ4* / serine/threonine kinase 38* / Mus musculus serine/threonine kinase 38 (Stk38), transcript variant 2, mRNA.*ENSDARG0000001851618
stk38a / serine/threonine kinase 38a / STK38* / Q15208* / Q91VJ4* / serine/threonine kinase 38* / Mus musculus serine/threonine kinase 38 (Stk38), transcript variant 2, mRNA.*ENSDARG0000001997318
cdc42bpab / CDC42 binding protein kinase alpha (DMPK-like) b / Q9Y5S2* / Q3UU96* / Q5VT25* / Q7TT50* / CDC42BPA* / CDC42BPB* / CDC42 binding protein kinase beta* / CDC42 binding protein kin...ENSDARG0000001646416
rock1 / Rho-associated, coiled-coil containing protein kinase 1 / Q13464*ENSDARG0000005899315
rock2b / rho-associated, coiled-coil containing protein kinase 2b / ROCK2* / O75116* / Rho associated coiled-coil containing protein kinase 2*ENSDARG0000000487715
cdc42bpb / CDC42 binding protein kinase beta (DMPK-like)ENSDARG0000001938315
rock2a / rho-associated, coiled-coil containing protein kinase 2a / ROCK2* / O75116* / Rho associated coiled-coil containing protein kinase 2*ENSDARG0000001750015
cdc42bpaa / CDC42 binding protein kinase alpha (DMPK-like) a / Q9Y5S2* / Q3UU96* / Q5VT25* / Q7TT50* / CDC42BPA* / CDC42BPB* / CDC42 binding protein kinase beta* / CDC42 binding protein kin...ENSDARG0000010428315
DMPK / DM1 protein kinase / Q09013*ENSDARG0000007491414
cita / citron rho-interacting serine/threonine kinase aENSDARG0000008985613
si:dkey-65b13.9 / ROCK2* / O75116* / Rho associated coiled-coil containing protein kinase 2*ENSDARG000001052498
citb / citron rho-interacting serine/threonine kinase b / CIT* / O14578* / citron rho-interacting serine/threonine kinase*ENSDARG000000888251
rock2b / rho-associated, coiled-coil containing protein kinase 2b / ROCK2* / O75116* / Rho associated coiled-coil containing protein kinase 2*ENSDARG000000964330


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR028741  Serine/threonine-protein kinase LATS1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035329 hippo signaling IEA
 biological_processGO:0060027 convergent extension involved in gastrulation IMP
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Signaling by Hippo


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011312 stk3 / Q7ZUQ3 / serine/threonine kinase 3 (STE20 homolog, yeast) / Q13188* / Q9JI10* / serine/threonine kinase 3* / Mus musculus serine/threonine kinase 3 (Stk3), transcript variant 2, mRNA.*  / reaction
 ENSDARG00000068401 yap1 / Q1L8J7 / Yes-associated protein 1 / P46937* / P46938*  / reaction
 ENSDARG00000076041 wwc1 / WW and C2 domain containing 1 / Q8IX03*  / complex / reaction
 ENSDARG00000009169 mob1ba / MOB kinase activator 1Ba / MOB1B* / Q8BPB0* / Q7L9L4* / MOB kinase activator 1B*  / complex / reaction
 ENSDARG00000067719 wwtr1 / WW domain containing transcription regulator 1 / Q9EPK5* / Q9GZV5*  / reaction






 

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