ENSDARG00000017500


Danio rerio

Features
Gene ID: ENSDARG00000017500
  
Biological name :rock2a
  
Synonyms : rho-associated, coiled-coil containing protein kinase 2a / rock2a
  
Possible biological names infered from orthology : O75116 / Rho associated coiled-coil containing protein kinase 2 / ROCK2
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 32815241
Gene end: 32899322
  
Corresponding Affymetrix probe sets: Dr.1706.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000122621
Ensembl peptide - ENSDARP00000135087
NCBI entrez gene - 317747     See in Manteia.
RefSeq - NM_174863
RefSeq Peptide - NP_777288
swissprot - A0A286Y953
swissprot - A0A0R4IHT4
swissprot - Q90Y37
ZFIN ID - ZDB-GENE-030115-3
Ensembl - ENSDARG00000017500
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ROCK2ENSGALG00000016451Gallus gallus
 ROCK2ENSG00000134318Homo sapiens
 Rock2ENSMUSG00000020580Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rock2b / rho-associated, coiled-coil containing protein kinase 2b / ROCK2* / O75116* / Rho associated coiled-coil containing protein kinase 2*ENSDARG0000000487766
rock1 / Rho-associated, coiled-coil containing protein kinase 1 / Q13464*ENSDARG0000005899361
cdc42bpab / CDC42 binding protein kinase alpha (DMPK-like) b / Q9Y5S2* / Q3UU96* / Q5VT25* / Q7TT50* / CDC42BPA* / CDC42BPB* / CDC42 binding protein kinase beta* / CDC42 binding protein kin...ENSDARG0000001646426
cdc42bpaa / CDC42 binding protein kinase alpha (DMPK-like) a / Q9Y5S2* / Q3UU96* / Q5VT25* / Q7TT50* / CDC42BPA* / CDC42BPB* / CDC42 binding protein kinase beta* / CDC42 binding protein kin...ENSDARG0000010428326
cdc42bpb / CDC42 binding protein kinase beta (DMPK-like)ENSDARG0000001938326
cita / citron rho-interacting serine/threonine kinase aENSDARG0000008985623
rock2b / rho-associated, coiled-coil containing protein kinase 2b / ROCK2* / O75116* / Rho associated coiled-coil containing protein kinase 2*ENSDARG0000009643316
citb / citron rho-interacting serine/threonine kinase b / CIT* / O14578* / citron rho-interacting serine/threonine kinase*ENSDARG0000008882512
lats2 / large tumor suppressor kinase 2 / Q7TSJ6* / Q9NRM7* / Serine/threonine-protein kinase LATS2 *ENSDARG0000007886412
DMPK / DM1 protein kinase / Q09013*ENSDARG0000007491412
stk38a / serine/threonine kinase 38a / STK38* / Q15208* / Q91VJ4* / serine/threonine kinase 38* / Mus musculus serine/threonine kinase 38 (Stk38), transcript variant 2, mRNA.*ENSDARG0000001997311
si:dkey-65b13.9 / ROCK2* / O75116* / Rho associated coiled-coil containing protein kinase 2*ENSDARG0000010524911
lats1 / large tumor suppressor kinase 1 / O95835* / Q8BYR2* / Serine/threonine-protein kinase LATS1 *ENSDARG0000000375111
stk38b / serine/threonine kinase 38b / STK38* / Q15208* / Q91VJ4* / serine/threonine kinase 38* / Mus musculus serine/threonine kinase 38 (Stk38), transcript variant 2, mRNA.*ENSDARG0000001851611
stk38l / serine/threonine kinase 38 like / Q7TSE6* / Q9Y2H1* / Mus musculus serine/threonine kinase 38 like (Stk38l), transcript variant 2, mRNA.*ENSDARG0000004548211


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011072  HR1 rho-binding domain
 IPR011993  PH-like domain superfamily
 IPR015008  Rho binding domain
 IPR017441  Protein kinase, ATP binding site
 IPR020684  Rho-associated protein kinase 1/2
 IPR029878  Rho-associated protein kinase 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006939 smooth muscle contraction IEA
 biological_processGO:0007039 protein catabolic process in the vacuole IPI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007266 Rho protein signal transduction IEA
 biological_processGO:0010825 positive regulation of centrosome duplication IEA
 biological_processGO:0016055 Wnt signaling pathway IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030163 protein catabolic process IPI
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0048333 mesodermal cell differentiation IGI
 biological_processGO:0060031 mediolateral intercalation IMP
 biological_processGO:0060775 planar cell polarity pathway involved in gastrula mediolateral intercalation IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005773 vacuole IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
EPHB-mediated forward signaling
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
VEGFA-VEGFR2 Pathway
RHO GTPases Activate ROCKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr