ENSG00000134318


Homo sapiens

Features
Gene ID: ENSG00000134318
  
Biological name :ROCK2
  
Synonyms : O75116 / Rho associated coiled-coil containing protein kinase 2 / ROCK2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p25.1
Gene start: 11179761
Gene end: 11348330
  
Corresponding Affymetrix probe sets: 202762_at (Human Genome U133 Plus 2.0 Array)   211504_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481789
Ensembl peptide - ENSP00000261535
Ensembl peptide - ENSP00000317985
Ensembl peptide - ENSP00000385509
Ensembl peptide - ENSP00000395957
NCBI entrez gene - 9475     See in Manteia.
OMIM - 604002
RefSeq - XM_017005379
RefSeq - NM_001321643
RefSeq - NM_004850
RefSeq - XM_005246190
RefSeq - XM_011510417
RefSeq - XM_017005378
RefSeq Peptide - NP_004841
RefSeq Peptide - NP_001308572
swissprot - E9PF63
swissprot - Q14DU5
swissprot - C9JFJ0
swissprot - D6REE7
swissprot - O75116
Ensembl - ENSG00000134318
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rock2aENSDARG00000017500Danio rerio
 rock2bENSDARG00000004877Danio rerio
 rock2bENSDARG00000096433Danio rerio
 si:dkey-65b13.9ENSDARG00000105249Danio rerio
 ROCK2ENSGALG00000016451Gallus gallus
 Rock2ENSMUSG00000020580Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1ENSG0000006790064
Q5VT25 / CDC42BPA / CDC42 binding protein kinase alphaENSG0000014377626
CIT / O14578 / citron rho-interacting serine/threonine kinaseENSG0000012296625
Q9Y5S2 / CDC42BPB / CDC42 binding protein kinase betaENSG0000019875225
Q6DT37 / CDC42BPG / CDC42 binding protein kinase gammaENSG0000017121924
DMPK / Q09013 / DM1 protein kinaseENSG0000010493614
LATS2 / Q9NRM7 / large tumor suppressor kinase 2ENSG0000015045712
STK38 / Q15208 / serine/threonine kinase 38ENSG0000011207911
Q9Y2H1 / STK38L / serine/threonine kinase 38 likeENSG0000021145511
LATS1 / O95835 / large tumor suppressor kinase 1ENSG0000013102311


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR015008  Rho binding domain
 IPR017441  Protein kinase, ATP binding site
 IPR020684  Rho-associated protein kinase 1/2
 IPR029875  Rho-associated protein kinase LET-502
 IPR029878  Rho-associated protein kinase 2
 IPR037311  Rho-associated protein kinase 2, HR1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006939 smooth muscle contraction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0007266 Rho protein signal transduction IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010825 positive regulation of centrosome duplication IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0018105 peptidyl-serine phosphorylation ISS
 biological_processGO:0018107 peptidyl-threonine phosphorylation IMP
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030155 regulation of cell adhesion TAS
 biological_processGO:0030866 cortical actin cytoskeleton organization IMP
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0035509 negative regulation of myosin-light-chain-phosphatase activity IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0039694 viral RNA genome replication IMP
 biological_processGO:0042752 regulation of circadian rhythm ISS
 biological_processGO:0045616 regulation of keratinocyte differentiation IMP
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051246 regulation of protein metabolic process ISS
 biological_processGO:0051298 centrosome duplication IMP
 biological_processGO:0051492 regulation of stress fiber assembly IEA
 biological_processGO:0051493 regulation of cytoskeleton organization IEA
 biological_processGO:0051893 regulation of focal adhesion assembly TAS
 biological_processGO:0071394 cellular response to testosterone stimulus IMP
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:0150033 negative regulation of protein localization to lysosome IMP
 biological_processGO:1902004 positive regulation of amyloid-beta formation ISS
 biological_processGO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISS
 biological_processGO:1902966 positive regulation of protein localization to early endosome IMP
 biological_processGO:1902993 positive regulation of amyloid precursor protein catabolic process ISS
 biological_processGO:1903140 regulation of establishment of endothelial barrier IMP
 biological_processGO:1903347 negative regulation of bicellular tight junction assembly IGI
 biological_processGO:2000114 regulation of establishment of cell polarity IEA
 biological_processGO:2000145 regulation of cell motility TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005198 structural molecule activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0017049 GTP-Rho binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0072518 Rho-dependent protein serine/threonine kinase activity IMP


Pathways (from Reactome)
Pathway description
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
VEGFA-VEGFR2 Pathway
RHO GTPases Activate ROCKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / complex / reaction
 ENSG00000092841 MYL6 / P60660 / myosin light chain 6  / reaction
 ENSG00000101335 MYL9 / P24844 / myosin light chain 9  / reaction
 ENSG00000058272 O14974 / PPP1R12A / protein phosphatase 1 regulatory subunit 12A  / reaction
 ENSG00000133026 MYH10 / P35580 / myosin heavy chain 10  / reaction
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / reaction
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / reaction
 ENSG00000107338 SHB / Q15464 / SH2 domain containing adaptor protein B  / reaction
 ENSG00000106683 LIMK1 / P53667 / LIM domain kinase 1  / reaction
 ENSG00000105357 MYH14 / Q7Z406 / myosin heavy chain 14  / reaction
 ENSG00000213639 P62140 / PPP1CB / protein phosphatase 1 catalytic subunit beta  / reaction
 ENSG00000118680 MYL12B / O14950 / myosin light chain 12B  / reaction
 ENSG00000133392 MYH11 / P35749 / myosin heavy chain 11  / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction
 ENSG00000077157 O60237 / PPP1R12B / protein phosphatase 1 regulatory subunit 12B  / reaction
 ENSG00000100345 MYH9 / P35579 / myosin heavy chain 9  / reaction
 ENSG00000112715 VEGFA / P15692 / vascular endothelial growth factor A  / reaction
 ENSG00000143878 RHOB / P62745 / ras homolog family member B  / complex / reaction
 ENSG00000155366 RHOC / P08134 / ras homolog family member C  / complex / reaction






 

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