ENSG00000107338


Homo sapiens

Features
Gene ID: ENSG00000107338
  
Biological name :SHB
  
Synonyms : Q15464 / SH2 domain containing adaptor protein B / SHB
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: p13.1
Gene start: 37919134
Gene end: 38069211
  
Corresponding Affymetrix probe sets: 1557458_s_at (Human Genome U133 Plus 2.0 Array)   204656_at (Human Genome U133 Plus 2.0 Array)   204657_s_at (Human Genome U133 Plus 2.0 Array)   243595_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000366936
NCBI entrez gene - 6461     See in Manteia.
OMIM - 600314
RefSeq - NM_003028
RefSeq Peptide - NP_003019
swissprot - Q15464
Ensembl - ENSG00000107338
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000026811Gallus gallus
 ShbENSMUSG00000044813Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AL138752.2ENSG0000025587257
SHD / Q96IW2 / Src homology 2 domain containing transforming protein DENSG0000010525135
SHF / Q7M4L6 / Src homology 2 domain containing FENSG0000013860633
SHE / Q5VZ18 / Src homology 2 domain containing EENSG0000016929128


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR035040  SH2 domain-containing adapter protein B
 IPR035045  SHB, SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IDA
 molecular_functionGO:0001784 phosphotyrosine residue binding IPI
 molecular_functionGO:0005070 SH3/SH2 adaptor activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
VEGFA-VEGFR2 Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000050820 BCAR1 / P56945 / BCAR1, Cas family scaffolding protein  / reaction / complex
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / complex / reaction
 ENSG00000089159 PXN / P49023 / paxillin  / complex / reaction
 ENSG00000112715 VEGFA / P15692 / vascular endothelial growth factor A  / reaction / complex
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / reaction / complex
 ENSG00000138448 ITGAV / P06756 / integrin subunit alpha V  / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction
 ENSG00000134318 ROCK2 / O75116 / Rho associated coiled-coil containing protein kinase 2  / reaction
 ENSG00000120899 PTK2B / Q14289 / protein tyrosine kinase 2 beta  / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000062598 ELMO2 / Q96JJ3 / engulfment and cell motility 2  / complex / reaction
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / reaction / complex
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / reaction / complex
 ENSG00000155849 ELMO1 / Q92556 / engulfment and cell motility 1  / reaction / complex
 ENSG00000150760 DOCK1 / Q14185 / dedicator of cytokinesis 1  / complex / reaction
 ENSG00000067900 ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1  / reaction
 ENSG00000259207 ITGB3 / P05106 / integrin subunit beta 3  / reaction






 

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