ENSG00000197122


Homo sapiens

Features
Gene ID: ENSG00000197122
  
Biological name :SRC
  
Synonyms : P12931 / SRC / SRC proto-oncogene, non-receptor tyrosine kinase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q11.23
Gene start: 37344685
Gene end: 37406050
  
Corresponding Affymetrix probe sets: 1558210_at (Human Genome U133 Plus 2.0 Array)   1558211_s_at (Human Genome U133 Plus 2.0 Array)   1565080_at (Human Genome U133 Plus 2.0 Array)   1565082_x_at (Human Genome U133 Plus 2.0 Array)   213324_at (Human Genome U133 Plus 2.0 Array)   221281_at (Human Genome U133 Plus 2.0 Array)   221284_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000350941
Ensembl peptide - ENSP00000362659
Ensembl peptide - ENSP00000362668
Ensembl peptide - ENSP00000362680
NCBI entrez gene - 6714     See in Manteia.
OMIM - 190090
RefSeq - XM_017028027
RefSeq - NM_005417
RefSeq - NM_198291
RefSeq - XM_017028024
RefSeq - XM_017028025
RefSeq - XM_017028026
RefSeq - XM_011529013
RefSeq Peptide - NP_938033
RefSeq Peptide - NP_005408
swissprot - P12931
Ensembl - ENSG00000197122
  
Related genetic diseases (OMIM): 114500 - Colon cancer, advanced, somatic, 114500
  616937 - ?Thrombocytopenia 6, 616937
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srcENSDARG00000008107Danio rerio
 SRCENSGALG00000003855Gallus gallus
 SrcENSMUSG00000027646Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
YES1 / P07947 / YES proto-oncogene 1, Src family tyrosine kinaseENSG0000017610576
FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinaseENSG0000001081069
FGR / P09769 / FGR proto-oncogene, Src family tyrosine kinaseENSG0000000093865
HCK / P08631 / HCK proto-oncogene, Src family tyrosine kinaseENSG0000010133654
BLK / P51451 / BLK proto-oncogene, Src family tyrosine kinaseENSG0000013657353
LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinaseENSG0000025408752
LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinaseENSG0000018286651
FRK / P42685 / fyn related Src family tyrosine kinaseENSG0000011181645
PTK6 / Q13882 / protein tyrosine kinase 6ENSG0000010121337
SRMS / Q9H3Y6 / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sitesENSG0000012550837


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001545 primary ovarian follicle growth IEA
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007172 signal complex assembly TAS
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0007229 integrin-mediated signaling pathway IMP
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0007417 central nervous system development IBA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0010447 response to acidic pH IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010632 regulation of epithelial cell migration IMP
 biological_processGO:0010634 positive regulation of epithelial cell migration IMP
 biological_processGO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0010907 positive regulation of glucose metabolic process IEA
 biological_processGO:0010954 positive regulation of protein processing IEA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0022407 regulation of cell-cell adhesion IMP
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway IBA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IEA
 biological_processGO:0032148 activation of protein kinase B activity IEA
 biological_processGO:0032211 negative regulation of telomere maintenance via telomerase IMP
 biological_processGO:0032463 negative regulation of protein homooligomerization IMP
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0033146 regulation of intracellular estrogen receptor signaling pathway IEA
 biological_processGO:0033625 positive regulation of integrin activation TAS
 biological_processGO:0034332 adherens junction organization IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0035635 entry of bacterium into host cell TAS
 biological_processGO:0036035 osteoclast development IBA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0038128 ERBB2 signaling pathway TAS
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043114 regulation of vascular permeability TAS
 biological_processGO:0043149 stress fiber assembly IMP
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
 biological_processGO:0043393 regulation of protein binding IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0045056 transcytosis IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045124 regulation of bone resorption TAS
 biological_processGO:0045453 bone resorption ISS
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046628 positive regulation of insulin receptor signaling pathway IEA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IBA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0048011 neurotrophin TRK receptor signaling pathway IEA
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0048477 oogenesis IEA
 biological_processGO:0050715 positive regulation of cytokine secretion IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IC
 biological_processGO:0050847 progesterone receptor signaling pathway IBA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0051057 positive regulation of small GTPase mediated signal transduction IMP
 biological_processGO:0051222 positive regulation of protein transport IEA
 biological_processGO:0051385 response to mineralocorticoid IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0051726 regulation of cell cycle IBA
 biological_processGO:0051895 negative regulation of focal adhesion assembly ISS
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 biological_processGO:0051902 negative regulation of mitochondrial depolarization IMP
 biological_processGO:0051974 negative regulation of telomerase activity IMP
 biological_processGO:0060065 uterus development IEA
 biological_processGO:0060444 branching involved in mammary gland duct morphogenesis IEA
 biological_processGO:0060491 regulation of cell projection assembly IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070542 response to fatty acid IEA
 biological_processGO:0070555 response to interleukin-1 IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071375 cellular response to peptide hormone stimulus ISS
 biological_processGO:0071393 cellular response to progesterone stimulus ISS
 biological_processGO:0071398 cellular response to fatty acid IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071498 cellular response to fluid shear stress IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0071801 regulation of podosome assembly IBA
 biological_processGO:0071803 positive regulation of podosome assembly IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IDA
 biological_processGO:0086098 angiotensin-activated signaling pathway involved in heart process ISS
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1900182 positive regulation of protein localization to nucleus IEA
 biological_processGO:1902533 positive regulation of intracellular signal transduction IEA
 biological_processGO:2000386 positive regulation of ovarian follicle development IEA
 biological_processGO:2000394 positive regulation of lamellipodium morphogenesis IMP
 biological_processGO:2000573 positive regulation of DNA biosynthetic process IEA
 biological_processGO:2000641 regulation of early endosome to late endosome transport IMP
 biological_processGO:2000811 negative regulation of anoikis IMP
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IMP
 biological_processGO:2001286 regulation of caveolin-mediated endocytosis IMP
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005901 caveola IDA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004713 protein tyrosine kinase activity NAS
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity TAS
 molecular_functionGO:0005070 SH3/SH2 adaptor activity TAS
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005158 insulin receptor binding IEA
 molecular_functionGO:0005178 integrin binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0016301 kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0020037 heme binding IDA
 molecular_functionGO:0030331 estrogen receptor binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042169 SH2 domain binding IPI
 molecular_functionGO:0044325 ion channel binding IPI
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0046875 ephrin receptor binding IPI
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS
 molecular_functionGO:0050839 cell adhesion molecule binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IPI
 molecular_functionGO:0051427 hormone receptor binding IBA
 molecular_functionGO:0070851 growth factor receptor binding IPI
 molecular_functionGO:0071253 connexin binding IEA
 molecular_functionGO:0097110 scaffold protein binding IPI


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
PIP3 activates AKT signaling
GAB1 signalosome
Downstream signal transduction
Constitutive Signaling by Aberrant PI3K in Cancer
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
DCC mediated attractive signaling
Netrin mediated repulsion signals
Regulation of commissural axon pathfinding by SLIT and ROBO
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by RAS mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PTK2 signaling
InlA-mediated entry of Listeria monocytogenes into host cells
Regulation of RUNX1 Expression and Activity
RUNX2 regulates osteoblast differentiation
Regulation of RUNX3 expression and activity
Activated NTRK2 signals through FYN
Activated NTRK3 signals through PI3K


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0000490 Deep set eyes 
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 HP:0000601 Hypotelorism 
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 HP:0000939 Osteoporosis "Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility. According to the WHO, osteoporosis is characterized by a value of BMD 2.5 standard deviations or more below the young adult mean." [HPO:curators]
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 HP:0001873 Thrombocytopenia 
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 HP:0002003 Large forehead 
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 HP:0002891 Uterine leiomyosarcoma 
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 HP:0004406 Spontaneous, recurrent epistaxis 
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 HP:0005584 Renal cell carcinoma "Renal cell carcinoma (also known as hypernephroma) is the most common form of kidney cancer arising from the proximal renal tubule. The tissue of origin for renal cell carcinoma is the proximal renal tubular epithelium. Renal cell carcinoma can be classified as 1) clear cell carcinoma, 2) papillary carcinoma, 3) chromophobe renal carcinoma, and 4) collecting duct carcinoma." [HPO:curators]
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 HP:0006716 Hereditary nonpolyposis colorectal carcinoma 
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 HP:0006740 Transitional cell carcinoma of the bladder 
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 HP:0006753 Increased gastric cancer 
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 HP:0011974 Myelofibrosis "Replacement of bone marrow by fibrous tissue." [HPO:probinson]
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 HP:0031020 Bone marrow hypercellularity "A larger than normal amount or percentage of hematopoietic cells relative to marrow fat." []
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000006451 RALA / P11233 / RAS like proto-oncogene A  / reaction
 ENSG00000050820 BCAR1 / P56945 / BCAR1, Cas family scaffolding protein  / reaction / complex
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / complex / reaction
 ENSG00000035403 VCL / P18206 / vinculin  / complex
 ENSG00000019991 HGF / P14210 / hepatocyte growth factor  / reaction / complex
 ENSG00000089159 PXN / P49023 / paxillin  / complex / reaction
 ENSG00000103653 CSK / P41240 / C-terminal Src kinase  / complex / reaction
 ENSG00000106299 WASL / O00401 / Wiskott-Aldrich syndrome like  / complex / reaction
 ENSG00000071051 NCK2 / O43639 / NCK adaptor protein 2  / reaction / complex
 ENSG00000112715 VEGFA / P15692 / vascular endothelial growth factor A  / complex / reaction
 ENSG00000132155 RAF1 / P04049 / Raf-1 proto-oncogene, serine/threonine kinase  / reaction / complex
 ENSG00000125650 PSPN / O60542 / persephin  / reaction / complex
 ENSG00000077264 PAK3 / O75914 / p21 (RAC1) activated kinase 3  / reaction / complex
 ENSG00000128052 KDR / P35968 / kinase insert domain receptor  / reaction / complex
 ENSG00000138448 ITGAV / P06756 / integrin subunit alpha V  / reaction
 ENSG00000110799 VWF / P04275 / von Willebrand factor  / reaction / complex
 ENSG00000005961 ITGA2B / P08514 / integrin subunit alpha 2b  / complex / reaction
 ENSG00000134853 P16234 / PDGFRA / platelet derived growth factor receptor alpha  / reaction / complex
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction
 ENSG00000134318 ROCK2 / O75116 / Rho associated coiled-coil containing protein kinase 2  / reaction
 ENSG00000113721 P09619 / PDGFRB / platelet derived growth factor receptor beta  / complex / reaction
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / complex / reaction
 ENSG00000168546 GFRA2 / O00451 / GDNF family receptor alpha 2  / reaction / complex
 ENSG00000144118 RALB / P11234 / RAS like proto-oncogene B  / reaction
 ENSG00000156299 TIAM1 / Q13009 / T cell lymphoma invasion and metastasis 1  / reaction / complex
 ENSG00000137693 YAP1 / P46937 / Yes associated protein 1  / reaction / complex
 ENSG00000171560 FGA / P02671 / fibrinogen alpha chain  / complex / reaction
 ENSG00000171119 NRTN / Q99748 / neurturin  / complex / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / complex / reaction
 ENSG00000171564 FGB / P02675 / fibrinogen beta chain  / complex / reaction
 ENSG00000020633 RUNX3 / Q13761 / runt related transcription factor 3  / reaction / complex
 ENSG00000146013 GFRA3 / O60609 / GDNF family receptor alpha 3  / complex / reaction
 ENSG00000152661 GJA1 / P17302 / gap junction protein alpha 1  / complex / reaction
 ENSG00000125861 GFRA4 / Q9GZZ7 / GDNF family receptor alpha 4  / complex / reaction
 ENSG00000140538 NTRK3 / Q16288 / neurotrophic receptor tyrosine kinase 3  / reaction / complex
 ENSG00000165731 RET / P07949 / ret proto-oncogene  / reaction / complex
 ENSG00000115414 FN1 / P02751 / fibronectin 1  / complex / reaction
 ENSG00000185652 NTF3 / P20783 / neurotrophin 3  / complex / reaction
 ENSG00000168621 GDNF / P39905 / glial cell derived neurotrophic factor  / reaction / complex
 ENSG00000169398 PTK2 / Q05397 / protein tyrosine kinase 2  / reaction / complex
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / complex / reaction
 ENSG00000171557 FGG / P02679 / fibrinogen gamma chain  / complex / reaction
 ENSG00000100311 PDGFB / P01127 / platelet derived growth factor subunit B  / reaction / complex
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction / complex
 ENSG00000104067 TJP1 / Q07157 / tight junction protein 1  / complex / reaction
 ENSG00000197461 PDGFA / P04085 / platelet derived growth factor subunit A  / complex / reaction
 ENSG00000151892 GFRA1 / P56159 / GDNF family receptor alpha 1  / reaction / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction
 ENSG00000176884 GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1  / reaction / complex
 ENSG00000120899 PTK2B / Q14289 / protein tyrosine kinase 2 beta  / reaction
 ENSG00000090776 EFNB1 / P98172 / ephrin B1  / reaction / complex
 ENSG00000065361 ERBB3 / P21860 / erb-b2 receptor tyrosine kinase 3  / reaction
 ENSG00000038382 TRIO / O75962 / trio Rho guanine nucleotide exchange factor  / reaction / complex
 ENSG00000146648 EGFR / P00533 / epidermal growth factor receptor  / reaction
 ENSG00000099204 ABLIM1 / O14639 / actin binding LIM protein 1  / complex / reaction
 ENSG00000062598 ELMO2 / Q96JJ3 / engulfment and cell motility 2  / complex / reaction
 ENSG00000259207 ITGB3 / P05106 / integrin subunit beta 3  / reaction / complex
 ENSG00000157168 NRG1 / Q02297 / neuregulin 1  / reaction
 ENSG00000182168 UNC5C / O95185 / unc-5 netrin receptor C  / reaction
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / reaction / complex
 ENSG00000198910 L1CAM / P32004 / L1 cell adhesion molecule  / reaction
 ENSG00000172243 CLEC7A / Q9BXN2 / C-type lectin domain containing 7A  / reaction
 ENSG00000107338 SHB / Q15464 / SH2 domain containing adaptor protein B  / complex / reaction
 ENSG00000137076 TLN1 / Q9Y490 / talin 1  / reaction / complex
 ENSG00000196776 CD47 / Q08722 / CD47 molecule  / reaction
 ENSG00000066248 NGEF / Q8N5V2 / neuronal guanine nucleotide exchange factor  / complex / reaction
 ENSG00000158092 NCK1 / P16333 / NCK adaptor protein 1  / complex / reaction
 ENSG00000178568 ERBB4 / Q15303 / erb-b2 receptor tyrosine kinase 4  / reaction / complex
 ENSG00000198053 SIRPA / P78324 / signal regulatory protein alpha  / reaction
 ENSG00000104695 P62714 / PPP2CB / protein phosphatase 2 catalytic subunit beta  / reaction
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / reaction / complex
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / reaction / complex
 ENSG00000137486 ARRB1 / P49407 / arrestin beta 1  / complex / reaction
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / reaction
 ENSG00000167601 AXL / P30530 / AXL receptor tyrosine kinase  / reaction / complex
 ENSG00000187323 DCC / P43146 / DCC netrin 1 receptor  / reaction / complex
 ENSG00000127314 RAP1B / P61224 / RAP1B, member of RAS oncogene family  / reaction / complex
 ENSG00000150760 DOCK1 / Q14185 / dedicator of cytokinesis 1  / complex / reaction
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex
 ENSG00000108947 EFNB3 / Q15768 / ephrin B3  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000136158 SPRY2 / O43597 / sprouty RTK signaling antagonist 2  / reaction
 ENSG00000105568 P30153 / PPP2R1A / protein phosphatase 2 scaffold subunit Aalpha  / reaction
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / complex / reaction
 ENSG00000158458 NRG2 / O14511 / neuregulin 2  / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / reaction / complex
 ENSG00000173156 RHOD / O00212 / ras homolog family member D  / complex / reaction
 ENSG00000102606 Q14155 / ARHGEF7 / Rho guanine nucleotide exchange factor 7  / complex / reaction
 ENSG00000181104 F2R / P25116 / coagulation factor II thrombin receptor  / complex / reaction
 ENSG00000163554 SPTA1 / P02549 / spectrin alpha, erythrocytic 1  / reaction
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / reaction
 ENSG00000124882 EREG / O14944 / epiregulin  / reaction
 ENSG00000147202 DIAPH2 / O60879 / diaphanous related formin 2  / reaction / complex
 ENSG00000173210 ABLIM3 / O94929 / actin binding LIM protein family member 3  / reaction / complex
 ENSG00000169752 NRG4 / Q8WWG1 / neuregulin 4  / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000116473 RAP1A / P62834 / RAP1A, member of RAS oncogene family  / reaction / complex
 ENSG00000108262 GIT1 / Q9Y2X7 / GIT ArfGAP 1  / reaction / complex
 ENSG00000113070 HBEGF / Q99075 / heparin binding EGF like growth factor  / reaction
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / reaction
 ENSG00000138798 EGF / P01133 / epidermal growth factor  / reaction
 ENSG00000141480 ARRB2 / P32121 / arrestin beta 2  / reaction / complex
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction / complex
 ENSG00000069509 FUNDC1 / Q8IVP5 / FUN14 domain containing 1  / reaction
 ENSG00000174808 BTC / P35070 / betacellulin  / reaction
 ENSG00000125266 EFNB2 / P52799 / ephrin B2  / complex / reaction
 ENSG00000155849 ELMO1 / Q92556 / engulfment and cell motility 1  / reaction / complex
 ENSG00000065320 NTN1 / O95631 / netrin 1  / reaction / complex
 ENSG00000077420 Q7Z5R6 / APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein  / reaction / complex
 ENSG00000163995 ABLIM2 / Q6H8Q1 / actin binding LIM protein family member 2  / reaction / complex
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / reaction / complex
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000159216 RUNX1 / Q01196 / runt related transcription factor 1  / reaction / complex
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000132670 PTPRA / P18433 / protein tyrosine phosphatase, receptor type A  / reaction
 ENSG00000148053 NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2  / reaction
 ENSG00000113575 P67775 / PPP2CA / protein phosphatase 2 catalytic subunit alpha  / reaction
 ENSG00000197694 Q13813 / SPTAN1 / spectrin alpha, non-erythrocytic 1  / reaction
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / reaction
 ENSG00000149294 NCAM1 / P13591 / neural cell adhesion molecule 1  / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / complex / reaction
 ENSG00000027869 Q9NP31 / SH2D2A / SH2 domain containing 2A  / reaction / complex
 ENSG00000117407 ARTN / Q5T4W7 / artemin  / complex / reaction
 ENSG00000196396 PTPN1 / P18031 / protein tyrosine phosphatase, non-receptor type 1  / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / reaction / complex
 ENSG00000067900 ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1  / reaction
 ENSG00000273079 GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B  / reaction / complex






 

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