ENSG00000006451


Homo sapiens

Features
Gene ID: ENSG00000006451
  
Biological name :RALA
  
Synonyms : P11233 / RALA / RAS like proto-oncogene A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: p14.1
Gene start: 39623483
Gene end: 39708124
  
Corresponding Affymetrix probe sets: 214435_x_at (Human Genome U133 Plus 2.0 Array)   224880_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000413227
Ensembl peptide - ENSP00000005257
Ensembl peptide - ENSP00000388975
NCBI entrez gene - 5898     See in Manteia.
OMIM - 179550
RefSeq - XM_011515466
RefSeq - NM_005402
RefSeq - XM_006715762
RefSeq Peptide - NP_005393
swissprot - P11233
swissprot - H7C3P7
swissprot - C9JPE8
Ensembl - ENSG00000006451
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ralaaENSDARG00000045463Danio rerio
 ralabENSDARG00000016253Danio rerio
 RALAENSGALG00000031893Gallus gallus
 RalaENSMUSG00000008859Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RALB / P11234 / RAS like proto-oncogene BENSG0000014411883
RRAS2 / P62070 / RAS related 2ENSG0000013381846
KRAS / P01116 / KRAS proto-oncogene, GTPaseENSG0000013370345
HRAS / P01112 / HRas proto-oncogene, GTPaseENSG0000017477544
RRAS / P10301 / RAS relatedENSG0000012645844
NRAS / P01111 / NRAS proto-oncogene, GTPaseENSG0000021328144
MRAS / O14807 / muscle RAS oncogene homologENSG0000015818643
ERAS / Q7Z444 / ES cell expressed RasENSG0000018768233
RERG / Q96A58 / RAS like estrogen regulated growth inhibitorENSG0000013453333
GEM / P55040 / GTP binding protein overexpressed in skeletal muscleENSG0000016494931
RRAD / P55042 / RRAD, Ras related glycolysis inhibitor and calcium channel regulatorENSG0000016659231
REM2 / Q8IYK8 / RRAD and GEM like GTPase 2ENSG0000013989031
REM1 / O75628 / RRAD and GEM like GTPase 1ENSG0000008832029
Q6T310 / RASL11A / RAS like family 11 member AENSG0000012203526
Q9NYN1 / RASL12 / RAS like family 12ENSG0000010371026
Q9BPW5 / RASL11B / RAS like family 11 member BENSG0000012804522
RERGL / Q9H628 / RERG likeENSG0000011140420


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR028412  Ras-related protein Ral


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0017157 regulation of exocytosis IDA
 biological_processGO:0031532 actin cytoskeleton reorganization IDA
 biological_processGO:0035722 interleukin-12-mediated signaling pathway TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051491 positive regulation of filopodium assembly IDA
 biological_processGO:0051665 membrane raft localization IDA
 biological_processGO:0061024 membrane organization TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IDA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0090543 Flemming body IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0017022 myosin binding IPI
 molecular_functionGO:0019003 GDP binding IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0031755 Edg-2 lysophosphatidic acid receptor binding IDA
 molecular_functionGO:0051117 ATPase binding IPI


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
p38MAPK events
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / reaction / complex
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction
 ENSG00000075624 ACTB / P60709 / actin beta  / reaction / complex
 ENSG00000184009 ACTG1 / P63261 / actin gamma 1  / reaction / complex
 ENSG00000197879 MYO1C / O00159 / myosin IC  / complex / reaction
 ENSG00000160271 Q12967 / RALGDS / ral guanine nucleotide dissociation stimulator  / reaction






 

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