ENSG00000197879


Homo sapiens

Features
Gene ID: ENSG00000197879
  
Biological name :MYO1C
  
Synonyms : MYO1C / myosin IC / O00159
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p13.3
Gene start: 1464186
Gene end: 1492812
  
Corresponding Affymetrix probe sets: 214656_x_at (Human Genome U133 Plus 2.0 Array)   225080_at (Human Genome U133 Plus 2.0 Array)   32811_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000459174
Ensembl peptide - ENSP00000460415
Ensembl peptide - ENSP00000460831
Ensembl peptide - ENSP00000461682
Ensembl peptide - ENSP00000493973
Ensembl peptide - ENSP00000352834
Ensembl peptide - ENSP00000354283
Ensembl peptide - ENSP00000412197
Ensembl peptide - ENSP00000437685
Ensembl peptide - ENSP00000459271
Ensembl peptide - ENSP00000459558
NCBI entrez gene - 4641     See in Manteia.
OMIM - 606538
RefSeq - NM_001080950
RefSeq - NM_033375
RefSeq - NM_001080779
RefSeq Peptide - NP_001074419
RefSeq Peptide - NP_001074248
RefSeq Peptide - NP_203693
swissprot - O00159
swissprot - F5H6E2
swissprot - I3L204
swissprot - I3L2C3
swissprot - I3L3F5
swissprot - I3L3Y6
swissprot - I3L501
Ensembl - ENSG00000197879
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A5PF48ENSDARG00000020924Danio rerio
 myo1cbENSDARG00000061579Danio rerio
 MYO1CENSGALG00000002709Gallus gallus
 Myo1cENSMUSG00000017774Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MYO1H / Q8N1T3 / myosin IHENSG0000017452759
MYO1B / O43795 / myosin IBENSG0000012864143
MYO1A / Q9UBC5 / myosin IAENSG0000016686641
MYO1D / O94832 / myosin IDENSG0000017665838
MYO1G / B0I1T2 / myosin IGENSG0000013628637
MYO1F / O00160 / myosin IFENSG0000014234736
MYO1E / Q12965 / myosin IEENSG0000015748335
MYO15A / Q9UKN7 / myosin XVAENSG0000009153631
MYO15B / myosin XVBENSG0000026671425


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR001609  Myosin head, motor domain
 IPR010926  Class I myosin tail homology domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036072  Class I myosin, motor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006605 protein targeting IDA
 biological_processGO:0006612 protein targeting to membrane IDA
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030050 vesicle transport along actin filament IEA
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0038089 positive regulation of cell migration by vascular endothelial growth factor signaling pathway IMP
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0045815 positive regulation of gene expression, epigenetic TAS
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0090314 positive regulation of protein targeting to membrane IMP
 biological_processGO:1900078 positive regulation of cellular response to insulin stimulus IEA
 biological_processGO:1900748 positive regulation of vascular endothelial growth factor signaling pathway IMP
 biological_processGO:2000810 regulation of bicellular tight junction assembly IMP
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0005903 brush border IEA
 cellular_componentGO:0009925 basal plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IDA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0016461 unconventional myosin complex TAS
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031941 filamentous actin IDA
 cellular_componentGO:0032420 stereocilium IEA
 cellular_componentGO:0032421 stereocilium bundle IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 cellular_componentGO:0060171 stereocilium membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000146 microfilament motor activity IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0017160 Ral GTPase binding IPI
 molecular_functionGO:0030898 actin-dependent ATPase activity IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Regulation of actin dynamics for phagocytic cup formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000006451 RALA / P11233 / RAS like proto-oncogene A  / reaction / complex
 ENSG00000184009 ACTG1 / P63261 / actin gamma 1  / reaction / complex
 ENSG00000075624 ACTB / P60709 / actin beta  / reaction / complex
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / complex






 

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