ENSG00000166866


Homo sapiens

Features
Gene ID: ENSG00000166866
  
Biological name :MYO1A
  
Synonyms : MYO1A / myosin IA / Q9UBC5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.3
Gene start: 57028517
Gene end: 57051198
  
Corresponding Affymetrix probe sets: 211916_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000300119
Ensembl peptide - ENSP00000400991
Ensembl peptide - ENSP00000451033
Ensembl peptide - ENSP00000452229
Ensembl peptide - ENSP00000393392
NCBI entrez gene - 4640     See in Manteia.
OMIM - 601478
RefSeq - XM_011538373
RefSeq - NM_001256041
RefSeq - NM_005379
RefSeq Peptide - NP_001242970
RefSeq Peptide - NP_005370
swissprot - Q9UBC5
swissprot - C9JU63
swissprot - G3V342
swissprot - G3V587
Ensembl - ENSG00000166866
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MYO1AENSGALG00000032598Gallus gallus
 Myo1aENSMUSG00000025401Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MYO1B / O43795 / myosin IBENSG0000012864159
MYO1C / O00159 / myosin ICENSG0000019787942
MYO1D / O94832 / myosin IDENSG0000017665839
MYO1G / B0I1T2 / myosin IGENSG0000013628638
MYO1H / Q8N1T3 / myosin IHENSG0000017452738
MYO1E / Q12965 / myosin IEENSG0000015748335
MYO1F / O00160 / myosin IFENSG0000014234734
MYO15A / Q9UKN7 / myosin XVAENSG0000009153631
MYO15B / myosin XVBENSG0000026671424


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR001609  Myosin head, motor domain
 IPR010926  Class I myosin tail homology domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036072  Class I myosin, motor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030033 microvillus assembly IEA
 biological_processGO:0051648 vesicle localization IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0005903 brush border IEA
 cellular_componentGO:0009925 basal plasma membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IDA
 cellular_componentGO:0031941 filamentous actin IDA
 cellular_componentGO:0044853 plasma membrane raft IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0000407 Hearing loss, sensorineural "Hearing loss caused by damage or dysfunction of the auditory nerve (cranial nerve VIII)." [HPO:curators]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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