ENSG00000091536


Homo sapiens

Features
Gene ID: ENSG00000091536
  
Biological name :MYO15A
  
Synonyms : MYO15A / myosin XVA / Q9UKN7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p11.2
Gene start: 18108706
Gene end: 18179806
  
Corresponding Affymetrix probe sets: 220288_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481642
Ensembl peptide - ENSP00000495720
Ensembl peptide - ENSP00000495481
Ensembl peptide - ENSP00000205890
Ensembl peptide - ENSP00000408800
Ensembl peptide - ENSP00000451782
Ensembl peptide - ENSP00000451925
Ensembl peptide - ENSP00000465910
Ensembl peptide - ENSP00000466630
Ensembl peptide - ENSP00000467989
NCBI entrez gene - 51168     See in Manteia.
OMIM - 602666
RefSeq - NM_016239
RefSeq - XM_017024714
RefSeq - XM_017024715
RefSeq Peptide - NP_057323
swissprot - A0A087WYA1
swissprot - Q9UKN7
swissprot - K7EQV1
swissprot - G3V4G3
swissprot - G3V4Q3
swissprot - K7EL45
swissprot - K7EMS7
Ensembl - ENSG00000091536
  
Related genetic diseases (OMIM): 600316 - Deafness, autosomal recessive 3, 600316
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myo15aaENSDARG00000075292Danio rerio
 myo15abENSDARG00000078474Danio rerio
 MYO15AENSGALG00000004978Gallus gallus
 Myo15ENSMUSG00000042678Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MYO15B / myosin XVBENSG0000026671427
MYO1F / O00160 / myosin IFENSG0000014234710
MYO1H / Q8N1T3 / myosin IHENSG000001745279
MYO1C / O00159 / myosin ICENSG000001978799
MYO1D / O94832 / myosin IDENSG000001766589
MYO1B / O43795 / myosin IBENSG000001286419
MYO1A / Q9UBC5 / myosin IAENSG000001668669
MYO1E / Q12965 / myosin IEENSG000001574839
MYO1G / B0I1T2 / myosin IGENSG000001362869


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000299  FERM domain
 IPR000857  MyTH4 domain
 IPR001452  SH3 domain
 IPR001609  Myosin head, motor domain
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR019748  FERM central domain
 IPR019749  Band 4.1 domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035487  Unconventional myosin-XV
 IPR035963  FERM superfamily, second domain
 IPR036028  SH3-like domain superfamily
 IPR036057  Class XV myosin, motor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0042472 inner ear morphogenesis IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0032420 stereocilium IEA
 cellular_componentGO:0032421 stereocilium bundle IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0011476 Profound sensorineural hearing impairment "Complete loss of hearing related to a sensorineural defect." [DDD:dfitzpatrick]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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