ENSMUSG00000042678


Mus musculus

Features
Gene ID: ENSMUSG00000042678
  
Biological name :Myo15
  
Synonyms : Myo15 / Q9QZZ4 / Unconventional myosin-XV
  
Possible biological names infered from orthology : MYO15A / myosin XVA / Q9UKN7
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B2
Gene start: 60469339
Gene end: 60528369
  
Corresponding Affymetrix probe sets: 10376615 (MoGene1.0st)   1421615_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071777
Ensembl peptide - ENSMUSP00000080507
Ensembl peptide - ENSMUSP00000091686
Ensembl peptide - ENSMUSP00000120839
NCBI entrez gene - 17910     See in Manteia.
MGI - MGI:1261811
RefSeq - XM_017314333
RefSeq - NM_001103171
RefSeq - NM_010862
RefSeq - NM_182698
RefSeq - XM_017314328
RefSeq - XM_017314329
RefSeq - XM_017314330
RefSeq - XM_017314331
RefSeq - XM_017314332
RefSeq - XM_017314319
RefSeq - XM_017314320
RefSeq - XM_017314321
RefSeq - XM_017314322
RefSeq - XM_017314323
RefSeq - XM_017314324
RefSeq - XM_017314325
RefSeq - XM_017314326
RefSeq - XM_017314327
RefSeq Peptide - NP_001096641
RefSeq Peptide - NP_034992
RefSeq Peptide - NP_874357
swissprot - Q9QZZ4
swissprot - F6VXK7
Ensembl - ENSMUSG00000042678
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myo15aaENSDARG00000075292Danio rerio
 myo15abENSDARG00000078474Danio rerio
 MYO15AENSGALG00000004978Gallus gallus
 MYO15AENSG00000091536Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myo15b / myosin XVBENSMUSG0000003442726
Myo1f / myosin IF / O00160*ENSMUSG0000002430010
Myo1a / O88329 / Unconventional myosin-Ia / Q9UBC5* / myosin IA*ENSMUSG000000254019
Myo1d / Q5SYD0 / Unconventional myosin-Id / O94832* / myosin ID*ENSMUSG000000354419
Myo1g / Q5SUA5 / Unconventional myosin-Ig / B0I1T2* / myosin IG*ENSMUSG000000204379
Myo1h / Q9D6A1 / Unconventional myosin-Ih / Q8N1T3* / myosin IH*ENSMUSG000000669529
Myo1b / P46735 / myosin IB / O43795*ENSMUSG000000184179
Myo1c / Q9WTI7 / Unconventional myosin-Ic / O00159* / myosin IC*ENSMUSG000000177749
Myo1e / E9Q634 / Unconventional myosin-Ie / Q12965* / myosin IE*ENSMUSG000000322209


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000299  FERM domain
 IPR000857  MyTH4 domain
 IPR001452  SH3 domain
 IPR001609  Myosin head, motor domain
 IPR011993  PH-like domain superfamily
 IPR014352  FERM/acyl-CoA-binding protein superfamily
 IPR019748  FERM central domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035487  Unconventional myosin-XV
 IPR035963  FERM superfamily, second domain
 IPR036028  SH3-like domain superfamily
 IPR036057  Class XV myosin, motor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0042472 inner ear morphogenesis IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0032420 stereocilium IDA
 cellular_componentGO:0032421 stereocilium bundle IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo15sh2/Myo15sh2
Genetic Background: Not Specified

Allelic Composition: Myo15sh2/Myo15sh2,Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn

 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myo15sh2/Myo15sh2
Genetic Background: Not Specified

 MP:0000048 abnormal stria vascularis "anomalous structure of the layer of highly vascularized pigmented granular cells on the outer wall of the cochlear duct" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Myo15sh2/Myo15sh2
Genetic Background: Not Specified

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * C57BL/6J

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Mc4rM4Btlr/Mc4r+
Genetic Background: C57BL/6J-Mc4rM4Btlr

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
Show

Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myo15sh2/Myo15sh2
Genetic Background: Not Specified

Allelic Composition: Myo15sh2-3J/Myo15sh2-3J
Genetic Background: C57BL/6J-Myo15sh2-3J/J

Allelic Composition: Myo15tm1.1(cre)Ugds/Myo15+,Ush1gtm1.1Ugds/Ush1gtm1.1Ugds
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Myo15m1Btlr/Myo15m1Btlr
Genetic Background: C57BL/6J-Myo15m1Btlr

Allelic Composition: Myo15m2Btlr/Myo15m2Btlr
Genetic Background: C57BL/6J-Myo15m2Btlr

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Kio/Gt(ROSA)26Sor+,Tg(Tnfrsf4-cre)1Nik/0
Genetic Background: B6.129-Tnfrsf4tm2(cre)Nik Gt(ROSA)26Sortm1(DTA)Kio

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
Show

Allelic Composition: Myo15sh2-3J/Myo15sh2-3J
Genetic Background: C57BL/6J-Myo15sh2-3J/J

Allelic Composition: Myo15m1Btlr/Myo15m1Btlr
Genetic Background: C57BL/6J-Myo15m1Btlr

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Myf6tm1Wb/Myf6tm1Wb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Myo15sh2/Myo15sh2
Genetic Background: Not Specified

Allelic Composition: Myo15sh2-3J/Myo15sh2-3J
Genetic Background: C57BL/6J-Myo15sh2-3J/J

Allelic Composition: Myo15tm1.1(cre)Ugds/Myo15+,Ush1gtm1.1Ugds/Ush1gtm1.1Ugds
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Pcdh15tm1.1Ugds/Pcdh15tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Myo15mpc190H/Myo15mpc190H
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Muc1tm1Gend/Muc1tm1Gend,Tg(Wnt1)1Hev/?
Genetic Background: involves: FVB

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo15sh2/Myo15sh2
Genetic Background: Not Specified

 MP:0002730 head shaking "compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274]
Show

Allelic Composition: Myo15sh2/Myo15sh2
Genetic Background: Not Specified

 MP:0002855 abnormal cochlear ganglion morphology "malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo15sh2/Myo15sh2
Genetic Background: Not Specified

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo15sh2/Myo15sh2
Genetic Background: Not Specified

 MP:0003149 abnormal tectorial membrane morphology "malformation, malfunction or absence of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
Show

Allelic Composition: Myo15sh2/Myo15sh2
Genetic Background: Not Specified

 MP:0003637 cochlear ganglion hypoplasia "reduced numbers of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo15sh2-3J/Myo15sh2-3J
Genetic Background: C57BL/6J-Myo15sh2-3J/J

 MP:0003879 abnormal hair cell physiology "anomolous function of the sensory epithelial cells of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100987]
Show

Allelic Composition: Myo15tm1.1(cre)Ugds/Myo15+,Ush1gtm1.1Ugds/Ush1gtm1.1Ugds
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0004333 abnormal utricular macula morphology "any structural abnormalities in the neuroepithelial sensory receptor in the inferolateral wall of the utricle; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies; normally sensitive to linear acceleration in the longitudinal axis of the body and to gravitational influences" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo15sh2/Myo15sh2
Genetic Background: Not Specified

 MP:0004399 abnormal cochlear outer hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spint1Gt(OST380474)Lex/Spint1Gt(OST380474)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0004405 absent cochlear hair cells "absence of the sensory epithelial cells of the cochlea; these cells are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo15sh2-3J/Myo15sh2-3J
Genetic Background: C57BL/6J-Myo15sh2-3J/J

 MP:0004413 absent cochlear microphonics "absence or loss of the bioelectric potentials produced by the hair cells of the organ of Corti in response to sound" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo15tm1.1(cre)Ugds/Myo15+,Ush1gtm1.1Ugds/Ush1gtm1.1Ugds
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0004415 abnormal cochlear nerve compound action potential "anomaly in the combined potentials resulting from activation of the auditory division of the eighth cranial nerve; these potentials represent the summed activity of multiple cochlear afferent fibers discharging synchronously and thus assess the combined functional state of OHCs, IHCs, and their primary afferent innervation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcdh15tm1.1Ugds/Pcdh15tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0004431 abnormal hair cell mechanoelectric transduction "anomalous conversion of mechanical energy into electric(al) energy by sensory cells, such as auditory and vestibular hair cells, required for auditory sensation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo15tm1.1(cre)Ugds/Myo15+,Ush1gtm1.1Ugds/Ush1gtm1.1Ugds
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Pcdh15tm1.1Ugds/Pcdh15tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo15sh2/Myo15sh2,Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn

 MP:0004524 short cochlear hair cell stereocilia "reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo15sh2/Myo15sh2,Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn

 MP:0004527 abnormal outer hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo15tm1.1(cre)Ugds/Myo15+,Ush1gtm1.1Ugds/Ush1gtm1.1Ugds
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Pcdh15tm1.1Ugds/Pcdh15tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0004529 decreased outer hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo15tm1.1(cre)Ugds/Myo15+,Ush1gtm1.1Ugds/Ush1gtm1.1Ugds
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Pcdh15tm1.1Ugds/Pcdh15tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0004531 short outer hair cell stereocilia "reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spint1Gt(OST380474)Lex/Spint1Gt(OST380474)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Myo15tm1.1(cre)Ugds/Myo15+,Ush1gtm1.1Ugds/Ush1gtm1.1Ugds
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Pcdh15tm1.1Ugds/Pcdh15tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0004532 abnormal inner hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typically linear or U-shaped pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear IHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo15tm1.1(cre)Ugds/Myo15+,Ush1gtm1.1Ugds/Ush1gtm1.1Ugds
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0004534 decreased inner hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo15tm1.1(cre)Ugds/Myo15+,Ush1gtm1.1Ugds/Ush1gtm1.1Ugds
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Pcdh15tm1.1Ugds/Pcdh15tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0004536 short inner hair cell stereocilia "reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo15tm1.1(cre)Ugds/Myo15+,Ush1gtm1.1Ugds/Ush1gtm1.1Ugds
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Pcdh15tm1.1Ugds/Pcdh15tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0004578 abnormal cochlear hair bundle tip links "any structural abnormality in single, three-stranded interrow filaments that extend obliquely from the tip of one stereocilium to the lateral side of an adjacent taller stereocilium; in the mouse, tip links are already detectable prenatally and persist throughout life; tips links are thought to gate the mechanotransducer channel, are lost from the cell surface after exposure to either calcium chelator BAPTA or lanthanum, and resist degradation by the protease subtilisin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo15tm1.1(cre)Ugds/Myo15+,Ush1gtm1.1Ugds/Ush1gtm1.1Ugds
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Pcdh15tm1.1Ugds/Pcdh15tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0004737 absent distortion product otoacoustic emissions "failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo15tm1.1(cre)Ugds/Myo15+,Ush1gtm1.1Ugds/Ush1gtm1.1Ugds
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0004738 abnormal brainstem auditory evoked potential "anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pcdh15tm1.1Ugds/Pcdh15tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0004742 abnormal vestibular system physiology "any functional anomaly of the sensory system responsible for the sense of head position and movement of the body through space; such anomalies may include impaired balance, dizziness, poor regulation of postural muscle tone and inability to detect quick movements of the head " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo15tm1.1(cre)Ugds/Myo15+,Ush1gtm1.1Ugds/Ush1gtm1.1Ugds
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0004748 increased susceptibility to age-related hearing loss "greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo6sv/Myo6sv
Genetic Background: involves: B10.HA/(33NX)Sn * C57BL/6J

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myo15m1Btlr/Myo15m1Btlr
Genetic Background: C57BL/6J-Myo15m1Btlr

Allelic Composition: Myo15m2Btlr/Myo15m2Btlr
Genetic Background: C57BL/6J-Myo15m2Btlr

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0006335 abnormal hearing electrophysiology "anomaly in auditory function as it relates to electrical phenomena" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo15tm1.1(cre)Ugds/Myo15+,Ush1gtm1.1Ugds/Ush1gtm1.1Ugds
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Myo15tm1.1(cre)Ugds/Myo15+,Ush1gtm1.1Ugds/Ush1gtm1.1Ugds
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Cdh23tm1.1Ugds/Cdh23tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

Allelic Composition: Pcdh15tm1.1Ugds/Pcdh15tm1.1Ugds,Myo15tm1.1(cre)Ugds/Myo15+
Genetic Background: involves: 129S1/SvImJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr