ENSMUSG00000032220


Mus musculus

Features
Gene ID: ENSMUSG00000032220
  
Biological name :Myo1e
  
Synonyms : E9Q634 / Myo1e / Unconventional myosin-Ie
  
Possible biological names infered from orthology : myosin IE / Q12965
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: D
Gene start: 70207350
Gene end: 70399766
  
Corresponding Affymetrix probe sets: 10586781 (MoGene1.0st)   1420159_at (Mouse Genome 430 2.0 Array)   1420160_s_at (Mouse Genome 430 2.0 Array)   1428509_at (Mouse Genome 430 2.0 Array)   1449941_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034745
Ensembl peptide - ENSMUSP00000150376
NCBI entrez gene - 71602     See in Manteia.
MGI - MGI:106621
RefSeq - NM_181072
RefSeq - XM_011242814
RefSeq Peptide - NP_851417
swissprot - E9Q634
swissprot - A0A1L1STM1
Ensembl - ENSMUSG00000032220
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myo1eaENSDARG00000036179Danio rerio
 MYO1EENSGALG00000004150Gallus gallus
 MYO1EENSG00000157483Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myo1f / myosin IF / O00160*ENSMUSG0000002430071
Myo1b / P46735 / myosin IB / O43795*ENSMUSG0000001841735
Myo1c / Q9WTI7 / Unconventional myosin-Ic / O00159* / myosin IC*ENSMUSG0000001777434
Myo1a / O88329 / Unconventional myosin-Ia / Q9UBC5* / myosin IA*ENSMUSG0000002540134
Myo1h / Q9D6A1 / Unconventional myosin-Ih / Q8N1T3* / myosin IH*ENSMUSG0000006695232
Myo1d / Q5SYD0 / Unconventional myosin-Id / O94832* / myosin ID*ENSMUSG0000003544131
Myo1g / Q5SUA5 / Unconventional myosin-Ig / B0I1T2* / myosin IG*ENSMUSG0000002043730
Myo15 / Q9QZZ4 / Unconventional myosin-XV / MYO15A* / Q9UKN7* / myosin XVA*ENSMUSG0000004267830
Myo15b / myosin XVBENSMUSG0000003442725


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR001452  SH3 domain
 IPR001609  Myosin head, motor domain
 IPR010926  Class I myosin tail homology domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035507  Unconventional myosin-Ie/If, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036072  Class I myosin, motor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0003094 glomerular filtration IMP
 biological_processGO:0006807 nitrogen compound metabolic process IMP
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0032836 glomerular basement membrane development IMP
 biological_processGO:0035166 post-embryonic hemopoiesis IMP
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IMP
 biological_processGO:0072015 glomerular visceral epithelial cell development IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton ISO
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005912 adherens junction IDA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045334 clathrin-coated endocytic vesicle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA
 molecular_functionGO:0042623 ATPase activity, coupled IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000315 hemoglobinuria "the presence of hemoglobin in the urine, including certain closely related pigments that are formed from slight alteration of the hemoglobin molecule" [J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: involves: 129S6/SvEvTac

 MP:0000767 abnormal smooth muscle morphology "anomalous structure of any of the unstriated muscle fibers of the internal organs, blood vessels, hair follicles, etc. " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo1eGt(ROSA)74Sor/Myo1eGt(ROSA)74Sor,Pdgfrbtm1Sor/Pdgfrb+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Myo1eGt(ROSA)74Sor/Myo1eGt(ROSA)74Sor,Pdgfratm2Sor/Pdgfra+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002847 abnormal glomerular filtration rate "deviation from the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: involves: 129S6/SvEvTac

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: B6.129S6-Myo1etm1.1Flv

Allelic Composition: Myo1etm1Flv/Myo1etm1Flv,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Myo1etm1Flv/Myo1etm1.1Flv,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: involves: 129S6/SvEvTac

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: involves: 129S6/SvEvTac

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: involves: 129S6/SvEvTac

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: involves: 129S6/SvEvTac

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: involves: 129S6/SvEvTac

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: involves: 129S6/SvEvTac

 MP:0005097 polychromatophilia "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
Show

Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005161 hematuria "presence of blood in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:78193]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: B6.129S6-Myo1etm1.1Flv

Allelic Composition: Myo1etm1Flv/Myo1etm1Flv,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Myo1etm1Flv/Myo1etm1.1Flv,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myo1eGt(ROSA)74Sor/Myo1eGt(ROSA)74Sor,Pdgfrbtm1Sor/Pdgfrb+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: involves: 129S6/SvEvTac

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo1eGt(ROSA)74Sor/Myo1eGt(ROSA)74Sor,Pdgfrbtm1Sor/Pdgfrb+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: involves: 129S6/SvEvTac

 MP:0008059 abnormal podocyte foot process morphology "any structural anomaly of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: B6.129S6-Myo1etm1.1Flv

Allelic Composition: Myo1etm1Flv/Myo1etm1Flv,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008140 podocyte foot process effacement "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: B6.129S6-Myo1etm1.1Flv

Allelic Composition: Myo1etm1Flv/Myo1etm1Flv,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: involves: 129S6/SvEvTac

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Arid5bGt(ROSA)75Sor/Arid5bGt(ROSA)75Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
Show

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: involves: 129S6/SvEvTac

 MP:0011348 abnormal renal glomerulus basement membrane morphology "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna]
Show

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: B6.129S6-Myo1etm1.1Flv

Allelic Composition: Myo1etm1Flv/Myo1etm1Flv,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0011352 proximal convoluted tubule brush border loss "attenuation or degeneration of the microvillus brush border normally present on the luminal surface of epithelial cells of the proximal convoluted tubule; may be associated with renal tubular injury and/or cystic changes" [MGI:anna]
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Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: involves: 129S6/SvEvTac

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: involves: 129S6/SvEvTac

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
Show

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: B6.129S6-Myo1etm1.1Flv

Allelic Composition: Myo1etm1Flv/Myo1etm1Flv,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Myo1etm1Flv/Myo1etm1.1Flv,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
Show

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: B6.129S6-Myo1etm1.1Flv

Allelic Composition: Myo1etm1Flv/Myo1etm1Flv,Tg(NPHS2-cre)295Lbh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0011418 leukocyturia "presence of white blood cells in the urine" [MGI:anna]
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Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: involves: 129S6/SvEvTac

 MP:0011868 podocyte microvillus transformation "aberrant formation of numerous slender cellular projections resembling microvilli or vesicle-like structures along the apical surface of podocytes, suggestive of podocyte injury" [MGI:anna]
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Allelic Composition: Myo1etm1.1Flv/Myo1etm1.1Flv
Genetic Background: B6.129S6-Myo1etm1.1Flv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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