ENSG00000164949


Homo sapiens

Features
Gene ID: ENSG00000164949
  
Biological name :GEM
  
Synonyms : GEM / GTP binding protein overexpressed in skeletal muscle / P55040
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q22.1
Gene start: 94249253
Gene end: 94262350
  
Corresponding Affymetrix probe sets: 204472_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000297596
Ensembl peptide - ENSP00000428258
Ensembl peptide - ENSP00000379497
NCBI entrez gene - 2669     See in Manteia.
OMIM - 600164
RefSeq - XM_017013315
RefSeq - NM_005261
RefSeq - NM_181702
RefSeq Peptide - NP_005252
RefSeq Peptide - NP_859053
swissprot - E5RJF9
swissprot - A0A024R9F5
swissprot - P55040
Ensembl - ENSG00000164949
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gemENSDARG00000029112Danio rerio
 GEMENSGALG00000032506Gallus gallus
 GemENSMUSG00000028214Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RRAD / P55042 / RRAD, Ras related glycolysis inhibitor and calcium channel regulatorENSG0000016659257
REM1 / O75628 / RRAD and GEM like GTPase 1ENSG0000008832051
REM2 / Q8IYK8 / RRAD and GEM like GTPase 2ENSG0000013989044
RRAS / P10301 / RAS relatedENSG0000012645823
RALB / P11234 / RAS like proto-oncogene BENSG0000014411822
RRAS2 / P62070 / RAS related 2ENSG0000013381821
RALA / P11233 / RAS like proto-oncogene AENSG0000000645121
Q9BPW5 / RASL11B / RAS like family 11 member BENSG0000012804520
Q9NYN1 / RASL12 / RAS like family 12ENSG0000010371020
MRAS / O14807 / muscle RAS oncogene homologENSG0000015818620
KRAS / P01116 / KRAS proto-oncogene, GTPaseENSG0000013370319
ERAS / Q7Z444 / ES cell expressed RasENSG0000018768219
RERG / Q96A58 / RAS like estrogen regulated growth inhibitorENSG0000013453319
NRAS / P01111 / NRAS proto-oncogene, GTPaseENSG0000021328118
HRAS / P01112 / HRas proto-oncogene, GTPaseENSG0000017477518
Q6T310 / RASL11A / RAS like family 11 member AENSG0000012203517
RERGL / Q9H628 / RERG likeENSG0000011140417


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR017358  Ras-related small G protein, RGK family
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0051276 chromosome organization IMP
 biological_processGO:0051310 metaphase plate congression IMP
 biological_processGO:1901842 negative regulation of high voltage-gated calcium channel activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0051233 spindle midzone IDA
 cellular_componentGO:0072686 mitotic spindle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0003924 GTPase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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