ENSMUSG00000028214


Mus musculus

Features
Gene ID: ENSMUSG00000028214
  
Biological name :Gem
  
Synonyms : Gem / GTP-binding protein GEM / P55041
  
Possible biological names infered from orthology : GTP binding protein overexpressed in skeletal muscle / P55040
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A1
Gene start: 11704457
Gene end: 11714752
  
Corresponding Affymetrix probe sets: 10503334 (MoGene1.0st)   1426063_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029868
Ensembl peptide - ENSMUSP00000103939
NCBI entrez gene - 14579     See in Manteia.
MGI - MGI:99844
RefSeq - NM_010276
RefSeq Peptide - NP_034406
swissprot - P55041
swissprot - Q3TH76
Ensembl - ENSMUSG00000028214
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gemENSDARG00000029112Danio rerio
 GEMENSGALG00000032506Gallus gallus
 GEMENSG00000164949Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rrad / Ras-related associated with diabetes / P55042* / RRAD, Ras related glycolysis inhibitor and calcium channel regulator*ENSMUSG0000003188057
Rem1 / O35929 / GTP-binding protein REM 1 / O75628* / RRAD and GEM like GTPase 1*ENSMUSG0000000035950
Rem2 / RRAD and GEM like GTPase 2 / Q8IYK8*ENSMUSG0000002217644
Rras / P10833 / related RAS viral (r-ras) oncogene / P10301* / RAS related*ENSMUSG0000003838723
Rala / P63321 / Ras-related protein Ral-A / P11233* / RAS like proto-oncogene A*ENSMUSG0000000885922
Ralb / Q9JIW9 / Ras-related protein Ral-B / P11234* / RAS like proto-oncogene B*ENSMUSG0000000445122
Rras2 / P62071 / Ras-related protein R-Ras2 / P62070* / RAS related 2*ENSMUSG0000005572321
Mras / O08989 / muscle and microspikes RAS / O14807* / muscle RAS oncogene homolog*ENSMUSG0000003247021
Q922H7 / Rasl11b / Ras-like protein family member 11B / Q9BPW5* / RAS like family 11 member B*ENSMUSG0000004990720
Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*ENSMUSG0000003026520
Q08AT1 / Rasl12 / Ras-like protein family member 12 / Q9NYN1* / RAS like family 12*ENSMUSG0000004169619
Rerg / Q8R367 / Ras-related and estrogen-regulated growth inhibitor / Q96A58* / RAS like estrogen regulated growth inhibitor*ENSMUSG0000003022219
Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*ENSMUSG0000002549918
Eras / Q7TN89 / GTPase ERas / Q7Z444* / ES cell expressed Ras*ENSMUSG0000003116018
Rergl / RERG/RAS-like / Q9H628* / RERG like*ENSMUSG0000009216418
Nras / neuroblastoma ras oncogene / P01111* / NRAS proto-oncogene, GTPase*ENSMUSG0000002785218
Q6IMB1 / Rasl11a / Ras-like protein family member 11A / Q6T310* / RAS like family 11 member A*ENSMUSG0000002964117


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR017358  Ras-related small G protein, RGK family
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0051276 chromosome organization ISO
 biological_processGO:0051310 metaphase plate congression ISO
 biological_processGO:1901842 negative regulation of high voltage-gated calcium channel activity IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0051233 spindle midzone ISO
 cellular_componentGO:0072686 mitotic spindle ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISO
 molecular_functionGO:0003924 GTPase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding ISO
 molecular_functionGO:0019003 GDP binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Dag1tm1.1Swin/Dag1tm1.1Swin,Dmdmdx/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/10ScSn

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dag1tm1.1Swin/Dag1tm1.1Swin,Dmdmdx/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/10ScSn

 MP:0004179 transmission ratio distortion "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dag1tm1.1Swin/Dag1tm1.1Swin,Dmdmdx/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/10ScSn

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dag1tm1.1Swin/Dag1tm1.1Swin,Dmdmdx/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/10ScSn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr