ENSMUSG00000027852


Mus musculus

Features
Gene ID: ENSMUSG00000027852
  
Biological name :Nras
  
Synonyms : neuroblastoma ras oncogene / Nras
  
Possible biological names infered from orthology : NRAS proto-oncogene, GTPase / P01111
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.2
Gene start: 103058285
Gene end: 103067914
  
Corresponding Affymetrix probe sets: 10494857 (MoGene1.0st)   1422687_at (Mouse Genome 430 2.0 Array)   1422688_a_at (Mouse Genome 430 2.0 Array)   1454060_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142438
Ensembl peptide - ENSMUSP00000143644
Ensembl peptide - ENSMUSP00000143620
Ensembl peptide - ENSMUSP00000143391
Ensembl peptide - ENSMUSP00000142603
Ensembl peptide - ENSMUSP00000029445
Ensembl peptide - ENSMUSP00000123081
Ensembl peptide - ENSMUSP00000142434
NCBI entrez gene - 18176     See in Manteia.
MGI - MGI:97376
RefSeq - XM_006501120
RefSeq - XM_006501121
RefSeq - XM_006501122
RefSeq - XM_006501123
RefSeq - NM_010937
RefSeq - XM_006501118
RefSeq - XM_006501119
RefSeq Peptide - NP_035067
swissprot - Q9D091
swissprot - A0A0G2JGP4
swissprot - A0A0G2JGM2
swissprot - A0A0G2JE25
swissprot - E9PVD5
Ensembl - ENSMUSG00000027852
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nrasENSDARG00000038225Danio rerio
 NRASENSGALG00000026692Gallus gallus
 NRASENSG00000213281Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*ENSMUSG0000002549986
Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*ENSMUSG0000003026584
Rras / P10833 / related RAS viral (r-ras) oncogene / P10301* / RAS related*ENSMUSG0000003838754
Rras2 / P62071 / Ras-related protein R-Ras2 / P62070* / RAS related 2*ENSMUSG0000005572353
Mras / O08989 / muscle and microspikes RAS / O14807* / muscle RAS oncogene homolog*ENSMUSG0000003247053
Ralb / Q9JIW9 / Ras-related protein Ral-B / P11234* / RAS like proto-oncogene B*ENSMUSG0000000445149
Rala / P63321 / Ras-related protein Ral-A / P11233* / RAS like proto-oncogene A*ENSMUSG0000000885948
Eras / Q7TN89 / GTPase ERas / Q7Z444* / ES cell expressed Ras*ENSMUSG0000003116043
Rerg / Q8R367 / Ras-related and estrogen-regulated growth inhibitor / Q96A58* / RAS like estrogen regulated growth inhibitor*ENSMUSG0000003022235
Q6IMB1 / Rasl11a / Ras-like protein family member 11A / Q6T310* / RAS like family 11 member A*ENSMUSG0000002964130
Rergl / RERG/RAS-like / Q9H628* / RERG like*ENSMUSG0000009216429
Gem / P55041 / GTP-binding protein GEM / P55040* / GTP binding protein overexpressed in skeletal muscle*ENSMUSG0000002821429
Rrad / Ras-related associated with diabetes / P55042* / RRAD, Ras related glycolysis inhibitor and calcium channel regulator*ENSMUSG0000003188029
Q922H7 / Rasl11b / Ras-like protein family member 11B / Q9BPW5* / RAS like family 11 member B*ENSMUSG0000004990729
Q08AT1 / Rasl12 / Ras-like protein family member 12 / Q9NYN1* / RAS like family 12*ENSMUSG0000004169628
Rem2 / RRAD and GEM like GTPase 2 / Q8IYK8*ENSMUSG0000002217627
Rem1 / O35929 / GTP-binding protein REM 1 / O75628* / RRAD and GEM like GTPase 1*ENSMUSG0000000035926


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0007165 signal transduction IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
Activation of RAS in B cells
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
p38MAPK events
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
FCERI mediated MAPK activation
NCAM signaling for neurite out-growth
VEGFR2 mediated cell proliferation
CD209 (DC-SIGN) signaling
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Regulation of RAS by GAPs
RAF activation
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Neutrophil degranulation
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAS signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nrastm1Tyj/Nras+,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Nrastm1Tyj/Nras+,Tg(Tyr-cre)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Krastm1Tyj/Krastm1Tyj
Genetic Background: involves: 129S2/SvPas

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krastm1Tyj/Krastm1Tyj
Genetic Background: involves: 129S2/SvPas

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Tyr-cre)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Nrastm1Tyj/Nras+,Tg(Tyr-cre)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0001188 hyperpigmentation "excess of pigment in any or all tissues or a part of a tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Nrastm1Tyj/Nrastm1Tyj,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: B6J.Cg-Nrastm1Tyj Cdkn2atm2.1Nesh Tg(Tyr-cre/ERT2)13Bos

Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Nrastm1.1Nesh/Nrastm1.1Nesh,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: B6J.Cg-Nrastm1.1Nesh Cdkn2atm2.1Nesh Tg(Tyr-cre/ERT2)13Bos

Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Nrastm1Tyj/Nras+,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Tyr-cre)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Nrastm1Tyj/Nras+,Tg(Tyr-cre)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0001272 increased metastatic potential 
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Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Nrastm1.1Nesh/Nrastm1.1Nesh,Stk11tm1.1Rdp/Stk11tm1.1Rdp,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: B6J.Cg-Nrastm1.1Nesh Cdkn2atm2.1Nesh Stk11tm1.1Rdp Tg(Tyr-cre/ERT2)13Bos

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Krastm1Tyj/Krastm1Tyj
Genetic Background: involves: 129S2/SvPas

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Tyr-cre)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Nrastm1Tyj/Nras+,Tg(Tyr-cre)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Tyr-cre)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Nrastm1Tyj/Nras+,Tg(Tyr-cre)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Cd72b/Cd72b,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0001721 absent blood islands "missing pools of blood in the yolk sac" [J:12623]
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Krastm1Tyj/Krastm1Tyj
Genetic Background: involves: 129S2/SvPas

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Flt4tm1.1Ichi/Flt4+
Genetic Background: B6.Cg-Flt4tm1.1Ichi

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Nlgn1tm1.1Sud/Nlgn1tm1.1Sud,Nlgn2tm1.1Sud/Nlgn2tm1.1Sud,Nlgn3tm4.1Sud/Y,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

Allelic Composition: Nrastm1Tyj/Nras+,Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Tyr-cre)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd72b/Cd72b,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Tyr-cre)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Nrastm1Tyj/Nras+,Tg(Tyr-cre)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd72b/Cd72b,Faslpr/Faslpr
Genetic Background: involves: C57BL/6 * C57BL/6JJmsSlc * MRL/Mp

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ddb2tm1Linn/Ddb2+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Hrastm1Esn/Hrastm1Esn,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6N

Allelic Composition: Nrastm1Mok/Nrastm1Mok
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)

Allelic Composition: Hrastm1Mok/Hrastm1Mok,Krastm1Mok/Krastm1Mok,Nrastm1Mok/Nrastm1Mok,Tg(HRAS)7Mok/0
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)

Allelic Composition: Nrastm3Emfu/Nrastm3Emfu
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Nrastm4Emfu/Nrastm4Emfu
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm1Tyj/Krastm1Tyj
Genetic Background: involves: 129S2/SvPas

 MP:0002738 hyperresponsive to tactile stimuli "exaggerated reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Tyr-cre)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Nrastm1Tyj/Nras+,Tg(Tyr-cre)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002877 abnormal melanocyte morphology "malformation of the cells that produce pigment " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Tyr-cre)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Tyr-cre)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Nrastm1Tyj/Nras+,Tg(Tyr-cre)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008111 abnormal granulocyte differentiaton "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0009391 abnormal leptomeninges pigmentation "any anomaly in the coloring of the two innermost layers of the meninges, including the pia mater and the arachnoid" [ISBN-13:978-1-4051-2034-0 "The Pigmentary System, Second Edition"]
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Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Tyr-cre)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0010275 increased melanoma incidence "greater than the expected number of malignant neoplasms, derived from melanocytes and occuring in pigmented tissues, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Tyr-cre)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0010322 increased cutaneous melanoma incidence "greater than the expected number of a dark-pigmented, usually malignant tumor arising from a melanocyte in the skin, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Nrastm1Tyj/Nrastm1Tyj,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: B6J.Cg-Nrastm1Tyj Cdkn2atm2.1Nesh Tg(Tyr-cre/ERT2)13Bos

Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Nrastm1.1Nesh/Nrastm1.1Nesh,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: B6J.Cg-Nrastm1.1Nesh Cdkn2atm2.1Nesh Tg(Tyr-cre/ERT2)13Bos

Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Nrastm1.1Nesh/Nrastm1.1Nesh,Stk11tm1.1Rdp/Stk11tm1.1Rdp,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: B6J.Cg-Nrastm1.1Nesh Cdkn2atm2.1Nesh Stk11tm1.1Rdp Tg(Tyr-cre/ERT2)13Bos

 MP:0010336 increased acute lymphoblastic leukemia incidence 
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Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0010741 abnormal melanocyte proliferation "anomaly in the ability of the a melanocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Nrastm1Tyj/Nrastm1Tyj,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: B6J.Cg-Nrastm1Tyj Cdkn2atm2.1Nesh Tg(Tyr-cre/ERT2)13Bos

Allelic Composition: Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh,Nrastm1.1Nesh/Nrastm1.1Nesh,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: B6J.Cg-Nrastm1.1Nesh Cdkn2atm2.1Nesh Tg(Tyr-cre/ERT2)13Bos

Allelic Composition: Nrastm1Tyj/Nrastm1Tyj,Tg(Tyr-cre)1Lru/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nrastm1Tyj/Nras+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nrastm1Mok/Nrastm1Mok
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Pitx1tm1Jdr/Pitx1tm1Jdr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011205 excessive folding of visceral yolk sac "the appearance of wrinkles or folds on the surface of the visceral yolk sac" [MGI:csmith, PMID:17881493]
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0012080 chylous ascites "the extravasation of milky triglyceride-rich chyle into the peritoneal cavity; often a secondary symptom of neoplasms" [MGI:csmith]
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Allelic Composition: Flt4tm1.1Ichi/Flt4+
Genetic Background: B6.Cg-Flt4tm1.1Ichi

Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nras+
Genetic Background: B6.129S-Nrastm1Mok Krastm1Mok

Allelic Composition: Hrastm1Mok/Hrastm1Mok,Nrastm1Mok/Nras+
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

Allelic Composition: Hrastm1Mok/Hrastm1Mok,Krastm1Mok/Kras+,Nrastm1Mok/Nras+
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

Allelic Composition: Hrastm1Mok/Hrastm1Mok,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

Allelic Composition: Hrastm1Mok/Hras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

Allelic Composition: Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Krastm1Tyj/Kras+,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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