ENSMUSG00000025499


Mus musculus

Features
Gene ID: ENSMUSG00000025499
  
Biological name :Hras
  
Synonyms : GTPase HRas GTPase HRas, N-terminally processed / Hras / Q61411
  
Possible biological names infered from orthology : HRas proto-oncogene, GTPase / P01112
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F5
Gene start: 141189105
Gene end: 141194005
  
Corresponding Affymetrix probe sets: 10569071 (MoGene1.0st)   1422407_s_at (Mouse Genome 430 2.0 Array)   1424132_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026572
Ensembl peptide - ENSMUSP00000138189
Ensembl peptide - ENSMUSP00000147731
Ensembl peptide - ENSMUSP00000147590
Ensembl peptide - ENSMUSP00000095570
Ensembl peptide - ENSMUSP00000132110
NCBI entrez gene - 15461     See in Manteia.
MGI - MGI:96224
RefSeq - NM_008284
RefSeq - XM_006536159
RefSeq - NM_001130443
RefSeq - NM_001130444
RefSeq Peptide - NP_001123915
RefSeq Peptide - NP_001123916
RefSeq Peptide - NP_032310
swissprot - A0A1B0GRN0
swissprot - C0H5X4
swissprot - Q61411
Ensembl - ENSMUSG00000025499
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hrasaENSDARG00000098497Danio rerio
 hrasbENSDARG00000005651Danio rerio
 H-RASENSGALG00000034526Gallus gallus
 H-RASENSGALG00000029260Gallus gallus
 HRASENSG00000174775Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nras / neuroblastoma ras oncogene / P01111* / NRAS proto-oncogene, GTPase*ENSMUSG0000002785286
Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*ENSMUSG0000003026583
Rras2 / P62071 / Ras-related protein R-Ras2 / P62070* / RAS related 2*ENSMUSG0000005572356
Rras / P10833 / related RAS viral (r-ras) oncogene / P10301* / RAS related*ENSMUSG0000003838754
Mras / O08989 / muscle and microspikes RAS / O14807* / muscle RAS oncogene homolog*ENSMUSG0000003247052
Ralb / Q9JIW9 / Ras-related protein Ral-B / P11234* / RAS like proto-oncogene B*ENSMUSG0000000445148
Rala / P63321 / Ras-related protein Ral-A / P11233* / RAS like proto-oncogene A*ENSMUSG0000000885948
Eras / Q7TN89 / GTPase ERas / Q7Z444* / ES cell expressed Ras*ENSMUSG0000003116043
Rerg / Q8R367 / Ras-related and estrogen-regulated growth inhibitor / Q96A58* / RAS like estrogen regulated growth inhibitor*ENSMUSG0000003022236
Q922H7 / Rasl11b / Ras-like protein family member 11B / Q9BPW5* / RAS like family 11 member B*ENSMUSG0000004990730
Gem / P55041 / GTP-binding protein GEM / P55040* / GTP binding protein overexpressed in skeletal muscle*ENSMUSG0000002821429
Q6IMB1 / Rasl11a / Ras-like protein family member 11A / Q6T310* / RAS like family 11 member A*ENSMUSG0000002964129
Rrad / Ras-related associated with diabetes / P55042* / RRAD, Ras related glycolysis inhibitor and calcium channel regulator*ENSMUSG0000003188029
Rergl / RERG/RAS-like / Q9H628* / RERG like*ENSMUSG0000009216429
Q08AT1 / Rasl12 / Ras-like protein family member 12 / Q9NYN1* / RAS like family 12*ENSMUSG0000004169628
Rem2 / RRAD and GEM like GTPase 2 / Q8IYK8*ENSMUSG0000002217627
Rem1 / O35929 / GTP-binding protein REM 1 / O75628* / RRAD and GEM like GTPase 1*ENSMUSG0000000035927


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0006897 endocytosis IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007050 cell cycle arrest ISO
 biological_processGO:0007093 mitotic cell cycle checkpoint ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IDA
 biological_processGO:0007265 Ras protein signal transduction IGI
 biological_processGO:0007569 cell aging IDA
 biological_processGO:0008283 cell proliferation IPI
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0032729 positive regulation of interferon-gamma production IMP
 biological_processGO:0034260 negative regulation of GTPase activity ISO
 biological_processGO:0035900 response to isolation stress IEA
 biological_processGO:0042088 T-helper 1 type immune response IMP
 biological_processGO:0042832 defense response to protozoan IMP
 biological_processGO:0043406 positive regulation of MAP kinase activity ISO
 biological_processGO:0043410 positive regulation of MAPK cascade ISO
 biological_processGO:0043524 negative regulation of neuron apoptotic process IGI
 biological_processGO:0043547 positive regulation of GTPase activity ISO
 biological_processGO:0045740 positive regulation of DNA replication ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046330 positive regulation of JNK cascade ISO
 biological_processGO:0046579 positive regulation of Ras protein signal transduction ISO
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IMP
 biological_processGO:0050679 positive regulation of epithelial cell proliferation ISO
 biological_processGO:0050852 T cell receptor signaling pathway IMP
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:0071480 cellular response to gamma radiation ISO
 biological_processGO:0090303 positive regulation of wound healing ISO
 biological_processGO:0090398 cellular senescence ISO
 biological_processGO:0097193 intrinsic apoptotic signaling pathway IMP
 biological_processGO:1900029 positive regulation of ruffle assembly ISO
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization ISO
 biological_processGO:2000630 positive regulation of miRNA metabolic process ISO
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding ISO
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0019003 GDP binding ISO


Pathways (from Reactome)
Pathway description
Activation of RAS in B cells
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
p38MAPK events
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
FCERI mediated MAPK activation
NCAM signaling for neurite out-growth
EPHB-mediated forward signaling
Ras activation upon Ca2+ influx through NMDA receptor
VEGFR2 mediated cell proliferation
CD209 (DC-SIGN) signaling
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Regulation of RAS by GAPs
RAF activation
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative regulation of MAPK pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAS signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000091 short premaxilla "reduced length of the anterior and interior portion of the maxilla" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000107 abnormal frontal bone morphology "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000440 domed skull 
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000630 mammary gland hyperplasia "increased size of mammary gland due to increased cell number" [J:63229]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Hrastm1Grnt/Hrastm1Grnt,Syngap1tm1Grnt/Syngap1+
Genetic Background: involves: 129P2/OlaHsd * MF1

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002014 papilloma "benign epithelial tumor" [J:47225]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ddb2tm1Linn/Ddb2+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Hrastm1Esn/Hrastm1Esn,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6N

Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Hrastm1Mok/Hrastm1Mok,Krastm1Mok/Krastm1Mok,Nrastm1Mok/Nrastm1Mok,Tg(HRAS)7Mok/0
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)

Allelic Composition: Hrastm1Rak/Hras+
Genetic Background: B6.129S4-Hrastm1Rak

 MP:0002576 abnormal enamel morphology "malformation of the hard outer coating of the exposed portion of the tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002649 abnormal enamel rod pattern "anomalous orientation of the structural unit of tooth enamel " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002650 abnormal ameloblast morphology "malformation of the epithelial cells of the inner layer of the enamel organ of the developing tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003108 short zygomatic bone "reduced length of the bone that forms the prominence of the cheek" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003404 absent enamel "absence of the hard outer coating of the exposed portion of the tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:92017]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003769 abnormal lip morphology "anomalous structure or development of the fleshy margins of the mouth" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003985 renal fibrosis "formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Destm1Cap/Destm1Cap,Tg(Bcl2)BCap/Tg(Bcl2)BCap
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008725 enlarged heart atrium "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008772 enlarged heart ventricle "increased average size of the heart ventricles compared to the average for a particular population" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009873 abnormal aorta tunica media morphology "any structural anomaly of the middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010234 abnormal vibrissa follicle morphology "any structural anomaly of one of the tubular invaginations of the epidermis enclosing the hair roots and from which grow the vibrissae located on the muzzle and face of many species" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010301 increased stomach tumor incidence "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010316 increased thyroid tumor incidence "greater than the expected number of neoplams in the thyroid occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Arid1atm1.1Mag/Arid1atm1.1Mag,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Allelic Composition: Hrastm1Jaf/Hrastm1Jaf,Trp53tm1Brn/Trp53tm1Brn,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * FVB/NCr

Allelic Composition: Hrastm1Jaf/Hrastm1Jaf,Ptentm2.1Ppp/Ptentm2.1Ppp,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/NCr

 MP:0010591 enlarged aortic valve "an increase in the total area occupied by the aortic valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Krastm1Mok/Kras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nrastm1Mok/Nrastm1Mok
Genetic Background: either: (involves: 129S/SvEv * C57BL/6) or (involves: 129S/SvEv * C57BL/6 * DBA/2)

 MP:0011471 decreased urine creatinine level "a reduced amount of creatinine in the urine compared to the normal state" [MGI:csmith]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012080 chylous ascites "the extravasation of milky triglyceride-rich chyle into the peritoneal cavity; often a secondary symptom of neoplasms" [MGI:csmith]
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Allelic Composition: Destm1Cap/Destm1Cap,Tg(Bcl2)BCap/Tg(Bcl2)BCap
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hrastm1Mok/Hrastm1Mok,Krastm1Mok/Kras+
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

Allelic Composition: Hrastm1Mok/Hrastm1Mok,Nrastm1Mok/Nras+
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

Allelic Composition: Hrastm1Mok/Hrastm1Mok,Krastm1Mok/Kras+,Nrastm1Mok/Nras+
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

Allelic Composition: Hrastm1Mok/Hrastm1Mok,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

Allelic Composition: Hrastm1Mok/Hras+,Nrastm1Mok/Nrastm1Mok
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0030034 depressed nasal bridge "posterior positioning of the saddle-shaped area that includes the nasal root and the lateral aspects of the nose in relation to the overall facial profile for age; normally, it lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canthi" [HP:0005280]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030036 short nasal bridge "reduced length of the saddle-shaped area that includes the nasal root and the lateral aspects of the nose; it lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canthi" [MGI:anna]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030062 choanal stenosis "abnormal narrowing of either of the pair of posterior apertures of the nasal cavity that open into the nasopharynx" [MGI:anna]
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Allelic Composition: Hrastm1Xbr/Hrastm1Xbr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030199 deviated nasal septum "displacement of the nasal septum in which the top of the cartilaginous ridge leans to the left or the right, causing obstruction of the affected nasal passage; normally, the septum lies centrally, and thus the nasal passages are symmetrical" [HP:0004411, https://en.wikipedia.org/wiki/Nasal_septum_deviation]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0030219 jaw cysts "presence of saccular lesions lined with epithelium and contained within pathologically formed cavities in the jaw; also non-epithelial cysts (pseudocysts) as they apply to the jaw, e.g., traumatic or solitary cyst, static bone cavity, and aneurysmal bone cyst; true jaw cysts are classified as odontogenic or non-odontogenic" [MESH:D007570, RDO:0005912]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0030450 abnormal enamel mineralization "anomaly in the process by which calcium salts, mainly carbonated hydroxyapatite, are deposited into the dental enamel" [GO:0070166]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0030471 abnormal ameloblast differentiation "any anomaly in the process in which a relatively unspecialized cell acquires specialized features of a functional ameloblast, a tall, columnar, polarized epithelial cell in the innermost layer of the enamel organ of a developing tooth involved with the formation of enamel matrix" [GO:0036305, PMID:19090561]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0030521 abnormal cervical loop morphology "any structural anomaly of the most cervical part of an enamel organ where the inner enamel epithelium and the outer enamel epithelium merge in a loop, thus delineating the end of the anatomic crown and the site where root formation begins; to form the root region, the cervical loop begins to grow deeper into the surrounding ectomesenchyme of the dental sac, elongating and moving away from the newly completed crown area to enclose more of the dental papilla, forming Hertwig s epithelial root sheath (HERS)" [https://books.google.com/books?isbn=0323290868, https://books.google.com/books?isbn=1455754099, https://www.stembook.org/node/551]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0030522 abnormal stellate reticulum morphology "any structural anomaly of the network of star-shaped cells found in the core of the dental (enamel) organ between the stratum intermedium and outer enamel epithelium which secrete hydrophilic glycosaminoglycans into the extracellular compartment; the stellate reticulum is most fully developed at the bell stage when intercellular spaces become fluid-filled, presumably related to osmotic effects arising from the high concentration of glycosaminoglycans; the main function of the stellate reticulum is mechanical, protecting the underlying dental tissues against physical disturbance and maintaining tooth shape" [http://dental.pitt.edu/periohistology-glossary, https://pocketdentistry.com/10-early-tooth-development-root-development-including-cementogenesis-and-tooth-eruption/]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0030523 abnormal stratum intermedium morphology "any structural anomaly of the layer of two or three flattened cells located between the inner enamel epithelium and the newly forming cells of the stellate reticulum; it first appears during the early bell stage of tooth development, has a notably high alkaline phosphatase activity, and forms a part of the dental (enamel) organ; this layer, along with the inner enamel epithelium, is responsible for the tooth enamel formation" [https://en.wikipedia.org/wiki/Stratum_intermedium, https://pocketdentistry.com/10-early-tooth-development-root-development-including-cementogenesis-and-tooth-eruption/]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000182 Fgf23 / Q9EPC2 / Fibroblast growth factor 23 / Q9GZV9*  / reaction
 ENSMUSG00000000441 Raf1 / Q99N57 / Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049* / Raf-1 proto-oncogene, serine/threonine kinase*  / reaction / complex
 ENSMUSG00000001127 Araf / P04627 / Serine/threonine-protein kinase A-Raf / P10398* / A-Raf proto-oncogene, serine/threonine kinase*  / reaction / complex
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / reaction
 ENSMUSG00000003099 Ppp5c / Q60676 / Serine/threonine-protein phosphatase 5 / P53041* / protein phosphatase 5 catalytic subunit*  / reaction
 ENSMUSG00000002413 Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSMUSG00000057897 Camk2b / P28652 / Calcium/calmodulin-dependent protein kinase type II subunit beta / Q13554* / calcium/calmodulin dependent protein kinase II beta*  / reaction
 ENSMUSG00000020734 Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*  / reaction
 ENSMUSG00000002771 Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*  / reaction
 ENSMUSG00000005320 Fgfr4 / fibroblast growth factor receptor 4 / P22455*  / reaction
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction
 ENSMUSG00000018334 Ksr1 / Q61097 / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA. / Q8IVT5* / kinase suppressor of ras 1*  / reaction / complex
 ENSMUSG00000020886 Dlg4 / Q62108 / Disks large homolog 4 / P78352* / discs large MAGUK scaffold protein 4*  / reaction
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / reaction
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / complex / reaction
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / reaction / complex
 ENSMUSG00000018326 Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*  / reaction / complex
 ENSMUSG00000035027 Q63932 / Map2k2 / Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA. / P36507* / AC011005.1* / mitogen-activated protein kinase kinase 2*  / reaction / complex
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / complex / reaction
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / complex / reaction
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / reaction / complex
 ENSMUSG00000029458 Brap / Q99MP8 / BRCA1-associated protein / Q7Z569*  / complex / reaction
 ENSMUSG00000021549 Rasa1 / RAS p21 protein activator 1 / P20936*  / complex / reaction
 ENSMUSG00000007411 Mark3 / Q03141 / MAP/microtubule affinity-regulating kinase 3 / P27448* / microtubule affinity regulating kinase 3*  / reaction / complex
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / complex / reaction
 ENSMUSG00000026821 Q03385 / Ralgds / ral guanine nucleotide dissociation stimulator / Q12967* / AL162417.1*  / reaction / complex
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / complex / reaction
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / complex / reaction
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / complex / reaction
 ENSMUSG00000004936 Map2k1 / P31938 / Dual specificity mitogen-activated protein kinase kinase 1 / Q02750* / mitogen-activated protein kinase kinase 1*  / reaction / complex
 ENSMUSG00000024486 Hbegf / Q06186 / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q99075* / heparin binding EGF like growth factor*  / reaction
 ENSMUSG00000024617 Camk2a / P11798 / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Q9UQM7* / calcium/calmodulin dependent protein kinase II alpha*  / reaction
 ENSMUSG00000022055 Nefl / P08551 / Neurofilament light polypeptide / P07196* / neurofilament light*  / reaction
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / reaction
 ENSMUSG00000032356 P27671 / Rasgrf1 / RAS protein-specific guanine nucleotide-releasing factor 1 / Q13972*  / reaction
 ENSMUSG00000029377 Ereg / Q61521 / Proepiregulin Epiregulin / O14944* / epiregulin*  / reaction
 ENSMUSG00000059003 Grin2a / P35436 / Glutamate receptor ionotropic, NMDA 2A / Q12879* / glutamate ionotropic receptor NMDA type subunit 2A*  / reaction
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction
 ENSMUSG00000031073 Fgf15 / O35622 / Fibroblast growth factor 15 / FGF19* / O95750* / fibroblast growth factor 19*  / reaction
 ENSMUSG00000028864 Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*  / reaction
 ENSMUSG00000026959 Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*  / reaction
 ENSMUSG00000032959 Pebp1 / P70296 / phosphatidylethanolamine binding protein 1 / P30086*  / reaction / complex
 ENSMUSG00000029195 Klb / Q99N32 / Beta-klotho / Q86Z14* / klotho beta*  / reaction
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction
 ENSMUSG00000021820 Camk2g / Q923T9 / Calcium/calmodulin-dependent protein kinase type II subunit gamma / Q13555* / calcium/calmodulin dependent protein kinase II gamma*  / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction
 ENSMUSG00000053819 Camk2d / Q6PHZ2 / Mus musculus calcium/calmodulin-dependent protein kinase II, delta (Camk2d), transcript variant 8, mRNA. / Q13557* / calcium/calmodulin dependent protein kinase II delta*  / reaction
 ENSMUSG00000061878 Sphk1 / Q8CI15 / Sphingosine kinase 1 / Q9NYA1*  / reaction
 ENSMUSG00000047104 Pbp2 / PEBP1* / P30086* / phosphatidylethanolamine binding protein 1*  / complex / reaction
 ENSMUSG00000052374 Actn2 / Q9JI91 / Alpha-actinin-2 / P35609* / actinin alpha 2*  / reaction
 ENSMUSG00000062312 Erbb2 / P70424 / Receptor tyrosine-protein kinase erbB-2 / P04626* / erb-b2 receptor tyrosine kinase 2*  / reaction
 ENSMUSG00000030209 Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*  / reaction
 ENSMUSG00000009376 Met / MET proto-oncogene, receptor tyrosine kinase / P08581*  / reaction
 ENSMUSG00000058488 Kl / O35082 / Klotho Klotho peptide / klotho* / Q9UEF7*  / reaction
 ENSMUSG00000071042 Rasgrp3 / RAS, guanyl releasing protein 3 / Q8IV61*  / reaction
 ENSMUSG00000031565 Fgfr1 / P16092 / Fibroblast growth factor receptor 1 / P11362*  / reaction
 ENSMUSG00000027347 Q9Z1S3 / Rasgrp1 / RAS guanyl releasing protein 1 / O95267*  / reaction
 ENSMUSG00000032311 Nrg4 / Q9WTX4 / Pro-neuregulin-4, membrane-bound isoform Neuregulin-4 / Q8WWG1* / neuregulin 4*  / reaction
 ENSMUSG00000023266 Frs3 / Q91WJ0 / Fibroblast growth factor receptor substrate 3 / O43559*  / reaction
 ENSMUSG00000062209 Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*  / reaction
 ENSMUSG00000082361 Btc / Q05928 / Probetacellulin Betacellulin / P35070* / betacellulin*  / reaction
 ENSMUSG00000038546 P69566 / Ranbp9 / Ran-binding protein 9 / Q96S59*  / reaction






 

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