ENSMUSG00000027347


Mus musculus

Features
Gene ID: ENSMUSG00000027347
  
Biological name :Rasgrp1
  
Synonyms : Q9Z1S3 / Rasgrp1 / RAS guanyl releasing protein 1
  
Possible biological names infered from orthology : O95267
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E5
Gene start: 117279993
Gene end: 117343001
  
Corresponding Affymetrix probe sets: 10486061 (MoGene1.0st)   1421176_at (Mouse Genome 430 2.0 Array)   1431749_a_at (Mouse Genome 430 2.0 Array)   1434295_at (Mouse Genome 430 2.0 Array)   1450143_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134027
Ensembl peptide - ENSMUSP00000136423
Ensembl peptide - ENSMUSP00000099593
Ensembl peptide - ENSMUSP00000133449
Ensembl peptide - ENSMUSP00000134167
Ensembl peptide - ENSMUSP00000134592
NCBI entrez gene - 19419     See in Manteia.
MGI - MGI:1314635
RefSeq - NM_011246
RefSeq Peptide - NP_035376
swissprot - Q9Z1S3
swissprot - G3UWW4
swissprot - G3UYC3
swissprot - G3UYP5
swissprot - G3UZQ7
Ensembl - ENSMUSG00000027347
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RASGRP1ENSGALG00000009740Gallus gallus
 O95267ENSG00000172575Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rasgrp3 / RAS, guanyl releasing protein 3 / Q8IV61*ENSMUSG0000007104244
Q8BTM9 / Rasgrp4 / RAS guanyl releasing protein 4 / Q8TDF6*ENSMUSG0000003058938
Q9QUG9 / Rasgrp2 / RAS, guanyl releasing protein 2 / Q7LDG7*ENSMUSG0000003294633
Rapgef6 / Rap guanine nucleotide exchange factor (GEF) 6 / Q8TEU7* / AC008695.1* / Rap guanine nucleotide exchange factor 6*ENSMUSG0000003753317
Q8CHG7 / Rapgef2 / Rap guanine nucleotide exchange factor 2 / Q9Y4G8*ENSMUSG0000006223217
Q8VCC8 / Rapgef3 / Mus musculus Rap guanine nucleotide exchange factor (GEF) 3 (Rapgef3), transcript variant 4, mRNA. / O95398* / Rap guanine nucleotide exchange factor 3*ENSMUSG0000002246912
Q9D300 / Rasgef1c / Ras-GEF domain-containing family member 1C / Q8N431* / RasGEF domain family member 1C*ENSMUSG0000002037411
Q8JZL7 / Rasgef1b / Ras-GEF domain-containing family member 1B / Q0VAM2* / RasGEF domain family member 1B*ENSMUSG0000008980911
Rasgef1a / RasGEF domain family, member 1A / Q8N9B8*ENSMUSG0000003013411
Q9EQZ6 / Rapgef4 / Rap guanine nucleotide exchange factor (GEF) 4 / Q8WZA2* / Rap guanine nucleotide exchange factor 4*ENSMUSG0000004904411
Q8C0Q9 / Rapgef5 / Rap guanine nucleotide exchange factor 5 / Q92565*ENSMUSG0000004199210
Q68EF8 / Rapgefl1 / Rap guanine nucleotide exchange factor-like 1 / Q9UHV5*ENSMUSG000000380209


Protein motifs (from Interpro)
Interpro ID Name
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR002048  EF-hand domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR029645  Ras guanyl-releasing protein 1/3
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0002437 inflammatory response to antigenic stimulus IMP
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032252 secretory granule localization IMP
 biological_processGO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production ISO
 biological_processGO:0032760 positive regulation of tumor necrosis factor production ISO
 biological_processGO:0032816 positive regulation of natural killer cell activation IMP
 biological_processGO:0032825 positive regulation of natural killer cell differentiation IMP
 biological_processGO:0033089 positive regulation of T cell differentiation in thymus IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043303 mast cell degranulation IMP
 biological_processGO:0043406 positive regulation of MAP kinase activity ISO
 biological_processGO:0043547 positive regulation of GTPase activity ISO
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity ISO
 biological_processGO:0046330 positive regulation of JNK cascade ISO
 biological_processGO:0046579 positive regulation of Ras protein signal transduction ISO
 biological_processGO:0047496 vesicle transport along microtubule IMP
 biological_processGO:0051259 protein complex oligomerization ISO
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:0090630 activation of GTPase activity ISO
 biological_processGO:1902715 positive regulation of interferon-gamma secretion ISO
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0042629 mast cell granule IEA
 molecular_functionGO:0001786 phosphatidylserine binding ISO
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity ISO
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005509 calcium ion binding ISO
 molecular_functionGO:0008270 zinc ion binding ISO
 molecular_functionGO:0019992 diacylglycerol binding ISO
 molecular_functionGO:0031210 phosphatidylcholine binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of RAS in B cells
Integrin alphaIIb beta3 signaling
Rap1 signalling
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Bcl10tm1Swm/Bcl10tm1Swm
Genetic Background: involves: 129P2/OlaHsd

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcl10tm1Swm/Bcl10tm1Swm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Genetic Background: involves: 129P3/J * C57BL/6J

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Genetic Background: B6.Cg-Rasgrp1tm1.1Wz

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bcl10tm1Swm/Bcl10tm1Swm
Genetic Background: involves: 129P2/OlaHsd

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Genetic Background: involves: 129P3/J * C57BL/6J

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cyp26a1tm1.1Ptk/Cyp26a1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn,Rasgrp3tm1Jstn/Rasgrp3tm1Jstn
Genetic Background: involves: 129P3/J * C57BL/6J

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bcl11atm1Pwt/Bcl11atm1Pwt,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Genetic Background: B6.Cg-Rasgrp1tm1.1Wz

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bcl10tm1Swm/Bcl10tm1Swm
Genetic Background: involves: 129P2/OlaHsd

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Genetic Background: involves: 129P3/J

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mtorchino/Mtorchino
Genetic Background: involves: C57BL/6JAnu

Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Genetic Background: involves: 129P3/J

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcl10tm1Swm/Bcl10tm1Swm
Genetic Background: involves: 129P2/OlaHsd

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Genetic Background: involves: 129P3/J * C57BL/6J

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcl10tm1Swm/Bcl10tm1Swm
Genetic Background: involves: 129P2/OlaHsd

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Genetic Background: B6.Cg-Rasgrp1tm1.1Wz

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Genetic Background: B6.Cg-Rasgrp1tm1.1Wz

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl10tm1Swm/Bcl10tm1Swm
Genetic Background: involves: 129P2/OlaHsd

 MP:0002828 abnormal glomerular capsule "anomalous structure or development of the expanded beginning of a nephron that contains the glomerulus" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl10tm1Swm/Bcl10tm1Swm
Genetic Background: involves: 129P2/OlaHsd

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Genetic Background: B6.Cg-Rasgrp1tm1.1Wz

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mtorchino/Mtorchino
Genetic Background: involves: C57BL/6JAnu

Allelic Composition: Rasgrp1m1Anu/Rasgrp1m1Anu
Genetic Background: involves: C57BL/6JSfdAnu * CBA/J

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl10tm1Swm/Bcl10tm1Swm
Genetic Background: involves: 129P2/OlaHsd

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
Show

Allelic Composition: Bcl10tm1Swm/Bcl10tm1Swm
Genetic Background: involves: 129P2/OlaHsd

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Genetic Background: B6.Cg-Rasgrp1tm1.1Wz

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcl10tm1Swm/Bcl10tm1Swm
Genetic Background: involves: 129P2/OlaHsd

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcl10tm1Swm/Bcl10tm1Swm
Genetic Background: involves: 129P2/OlaHsd

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Genetic Background: involves: 129P3/J * C57BL/6J

Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn,Rasgrp3tm1Jstn/Rasgrp3tm1Jstn
Genetic Background: involves: 129P3/J * C57BL/6J

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Genetic Background: B6.Cg-Rasgrp1tm1.1Wz

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Bcl10tm1Swm/Bcl10tm1Swm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Genetic Background: B6.Cg-Rasgrp1tm1.1Wz

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcl10tm1Swm/Bcl10tm1Swm
Genetic Background: involves: 129P2/OlaHsd

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Genetic Background: involves: 129P3/J

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Genetic Background: B6.Cg-Rasgrp1tm1.1Wz

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: C57BL/6 * BALB/c

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Genetic Background: involves: 129P3/J

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Genetic Background: B6.Cg-Rasgrp1tm1.1Wz

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Genetic Background: B6.Cg-Rasgrp1tm1.1Wz

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Genetic Background: B6.Cg-Rasgrp1tm1.1Wz

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Genetic Background: involves: 129P3/J * C57BL/6J

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn,Rasgrp3tm1Jstn/Rasgrp3tm1Jstn
Genetic Background: involves: 129P3/J * C57BL/6J

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Genetic Background: B6.Cg-Rasgrp1tm1.1Wz

 MP:0010835 increased CD4-positive, alpha-beta memory T cell number "increased number of CD4-positive, alpha-beta long-lived T cells with the phenotype CD45RO-positive and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000897, GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149]
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Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz
Genetic Background: B6.Cg-Rasgrp1tm1.1Wz

 MP:0010844 increased effector memory CD4-positive, alpha-beta T cell number "increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]
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Allelic Composition: Rasgrp1m1Anu/Rasgrp1m1Anu
Genetic Background: involves: C57BL/6JSfdAnu * CBA/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / reaction
 ENSMUSG00000052681 Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*  / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / reaction






 

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